TGFBRAP1 and TGFBR2

Number of citations of the paper that reports this interaction (PMID 11278302)
8

Data Source:
HPRD (in vivo)

		TGFBRAP1	TGFBR2
Gene Name		transforming growth factor, beta receptor associated protein 1	transforming growth factor, beta receptor II (70/80kDa)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Membrane	Cytosol Plasma Membrane Caveola External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex Transforming Growth Factor Beta Receptor Homodimeric Complex
	Molecular Function	Small GTPase Regulator Activity Transforming Growth Factor Beta Receptor Binding Protein Binding SMAD Binding	Transmembrane Receptor Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type II Protein Binding ATP Binding Glycosaminoglycan Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Type I Transforming Growth Factor Beta Receptor Binding Type III Transforming Growth Factor Beta Receptor Binding SMAD Binding Metal Ion Binding Transforming Growth Factor Beta Binding
	Biological Process	Regulation Of Transcription, DNA-templated Intracellular Protein Transport Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Vesicle-mediated Transport Regulation Of Catalytic Activity	Blood Vessel Development Patterning Of Blood Vessels Vasculogenesis In Utero Embryonic Development Positive Regulation Of Mesenchymal Cell Proliferation Lens Development In Camera-type Eye Positive Regulation Of Tolerance Induction To Self Antigen Positive Regulation Of B Cell Tolerance Induction Positive Regulation Of T Cell Tolerance Induction Growth Plate Cartilage Chondrocyte Growth Protein Phosphorylation Receptor-mediated Endocytosis Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway Common-partner SMAD Protein Phosphorylation Smoothened Signaling Pathway Gastrulation Brain Development Heart Development Embryo Implantation Aging Response To Nutrient Positive Regulation Of Cell Proliferation Response To Mechanical Stimulus Response To Glucose Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Signal Transduction By Phosphorylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Organ Regeneration Activation Of Protein Kinase Activity Embryonic Hemopoiesis Wound Healing Regulation Of Cell Proliferation Response To Drug Myeloid Dendritic Cell Differentiation Positive Regulation Of Skeletal Muscle Tissue Regeneration Response To Estrogen Positive Regulation Of Angiogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Embryonic Cranial Skeleton Morphogenesis Positive Regulation Of NK T Cell Differentiation Palate Development Negative Regulation Of Cardiac Muscle Cell Proliferation Pathway-restricted SMAD Protein Phosphorylation Bronchus Morphogenesis Trachea Formation Mammary Gland Morphogenesis Lung Lobe Morphogenesis Response To Cholesterol Lens Fiber Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways			Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
Drugs			Glycerol
Diseases
GWAS		AIDS ( 19754311) Obesity-related traits ( 23251661) Preeclampsia ( 23551011)	Breast cancer ( 23535729) Migraine ( 22683712) Tonometry ( 17903302)
Protein-Protein Interactions		9 interactors: ACVR1B ACVR2B ACVRL1 ALOX5 BMPR1A SMAD2 SMAD4 TGFBR1 TGFBR2	44 interactors: ACVR1 ACVRL1 AP2B1 APP ARHGEF6 ARHGEF7 CBL CCNB1 CCNB2 CD44 CDK1 CLU CTNNB1 DAB2 DAXX EIF3I ENG GOPC KCNK18 NRP1 OSR1 PAK1 PDGFRA PIK3R1 PIK3R2 PML RCVRN SMAD3 SMAD4 SMAD7 SNX6 STRAP TCTEX1D4 TERT TGFB1 TGFB1I1 TGFB2 TGFB3 TGFBR1 TGFBR3 TGFBRAP1 TRAP1 TSSK1B ZFYVE9
Entrez ID		9392	7048
HPRD ID		06948	01823
Ensembl ID		ENSG00000135966	ENSG00000163513
Uniprot IDs		Q8WUH2	A3QNQ0 D2JYI1 P37173
PDB IDs			1KTZ 1M9Z 1PLO 2PJY 3KFD
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Signaling Pathway Palate Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Enzyme Linked Receptor Protein Signaling Pathway In Utero Embryonic Development Signal Transduction By Phosphorylation Embryo Development Positive Regulation Of Protein Phosphorylation Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Positive Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Cardiovascular System Development Gastrulation Regulation Of Cell Differentiation Positive Regulation Of Protein Modification Process Positive Regulation Of SMAD Protein Import Into Nucleus Pattern Specification Process Tissue Development Heart Development Regulation Of SMAD Protein Import Into Nucleus BMP Signaling Pathway Regulation Of Protein Phosphorylation Intracellular Signal Transduction Epithelium Development Anterior/posterior Pattern Specification Cellular Response To Growth Factor Stimulus Positive Regulation Of Cellular Protein Metabolic Process Response To Growth Factor Embryonic Morphogenesis Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Phosphorylation Tube Development Response To Cholesterol Protein Phosphorylation Regulation Of Activin Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Mesoderm Development Positive Regulation Of Cellular Metabolic Process Tube Morphogenesis Positive Regulation Of BMP Signaling Pathway Regulation Of Signal Transduction	Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Response To Transforming Growth Factor Beta Regulation Of Signal Transduction Cellular Response To Organic Substance Regulation Of Signaling Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation Regulation Of Epithelial To Mesenchymal Transition Response To Organic Substance Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus Cell Surface Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Metabolic Process Regulation Of Catalytic Activity Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Tube Development Response To Wounding Regulation Of Cell Death Signaling Positive Regulation Of Phosphorylation Regulation Of Cell Differentiation Cellular Response To Stimulus Signal Transduction Cell Communication Response To Stress Regulation Of Gene Expression Regulation Of Apoptotic Process Tissue Morphogenesis Anatomical Structure Morphogenesis
Tagcloud ?		500k 9x10 affymetrix agp alleles anril atherosclerosis cad camta1 conjoint depth genotyping german highlighted illumina immunochip largest loci periodontitis plasminogen plg replicated rs2679895 rs4252120 sets shared vamp3 worldwide	aaa adventitial alleles aneurysm aortas aortic betatype disruption elastase elastin fourteen genetical infiltration infrarenal medial metalloproteinases myhcre peri principal prominently resident sm smc smooth transforming wise
Tagcloud (Difference) ?		500k 9x10 affymetrix agp anril atherosclerosis cad camta1 conjoint depth genotyping german highlighted illumina immunochip largest loci periodontitis plasminogen plg replicated rs2679895 rs4252120 sets shared vamp3 worldwide	aaa adventitial aneurysm aortas aortic betatype disruption elastase elastin fourteen genetical infiltration infrarenal medial metalloproteinases myhcre peri principal prominently resident sm smc smooth transforming wise
Tagcloud (Intersection) ?		alleles