TGFBRAP1 and ACVR2B

Number of citations of the paper that reports this interaction (PMID 11278302)
8

Data Source:
HPRD (in vivo)

		TGFBRAP1	ACVR2B
Gene Name		transforming growth factor, beta receptor associated protein 1	activin A receptor, type IIB
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Membrane	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	Small GTPase Regulator Activity Transforming Growth Factor Beta Receptor Binding Protein Binding SMAD Binding	Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Activin Receptor Activity, Type II Growth Factor Binding Inhibin Binding Metal Ion Binding Activin Binding
	Biological Process	Regulation Of Transcription, DNA-templated Intracellular Protein Transport Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Vesicle-mediated Transport Regulation Of Catalytic Activity	Gastrulation With Mouth Forming Second Kidney Development Lymphangiogenesis Blood Vessel Remodeling Regulation Of Transcription, DNA-templated Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Determination Of Left/right Symmetry Mesoderm Development Heart Development Response To Glucose Post-embryonic Development Anterior/posterior Pattern Specification Signal Transduction By Phosphorylation Insulin Secretion Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Pancreas Development Activation Of Protein Kinase Activity Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Organ Growth Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Osteoblast Differentiation Embryonic Foregut Morphogenesis Skeletal System Morphogenesis Palate Development Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Retina Vasculature Development In Camera-type Eye
Pathways			Signaling by Activin Regulation of signaling by NODAL Signaling by BMP Signaling by NODAL
Drugs
Diseases
GWAS		AIDS ( 19754311) Obesity-related traits ( 23251661) Preeclampsia ( 23551011)
Protein-Protein Interactions		9 interactors: ACVR1B ACVR2B ACVRL1 ALOX5 BMPR1A SMAD2 SMAD4 TGFBR1 TGFBR2	18 interactors: ACVR1B BMP10 BMP2 BMP7 ERBB2IP GDF11 GDF2 GDF5 IGSF1 INHBA INHBB INHBC MSTN SNX1 SNX2 SNX6 SYNJ2BP TGFBRAP1
Entrez ID		9392	93
HPRD ID		06948	04106
Ensembl ID		ENSG00000135966	ENSG00000114739
Uniprot IDs		Q8WUH2	Q13705
PDB IDs			2H62 2QLU 4FAO
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Signaling Pathway Palate Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Enzyme Linked Receptor Protein Signaling Pathway In Utero Embryonic Development Signal Transduction By Phosphorylation Embryo Development Positive Regulation Of Protein Phosphorylation Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Positive Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Cardiovascular System Development Gastrulation Regulation Of Cell Differentiation Positive Regulation Of Protein Modification Process Positive Regulation Of SMAD Protein Import Into Nucleus Pattern Specification Process Tissue Development Heart Development Regulation Of SMAD Protein Import Into Nucleus BMP Signaling Pathway Regulation Of Protein Phosphorylation Intracellular Signal Transduction Epithelium Development Anterior/posterior Pattern Specification Cellular Response To Growth Factor Stimulus Positive Regulation Of Cellular Protein Metabolic Process Response To Growth Factor Embryonic Morphogenesis Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Phosphorylation Tube Development Response To Cholesterol Protein Phosphorylation Regulation Of Activin Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Mesoderm Development Positive Regulation Of Cellular Metabolic Process Tube Morphogenesis Positive Regulation Of BMP Signaling Pathway Regulation Of Signal Transduction	Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Growth Positive Regulation Of Protein Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Activin Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process BMP Signaling Pathway Regulation Of Signal Transduction Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Death Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Pathway-restricted SMAD Protein Phosphorylation Cell Development Negative Regulation Of Cell Proliferation Regulation Of Cell Differentiation Regulation Of Metabolic Process Signal Transduction Negative Regulation Of Growth Tissue Development Positive Regulation Of Cell Differentiation Signaling Cell Communication Negative Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Anatomical Structure Development Regulation Of Growth Negative Regulation Of Cell Growth Lamellipodium Morphogenesis Positive Regulation Of Ovulation Regulation Of Follicle-stimulating Hormone Secretion Regulation Of Cell Proliferation Cartilage Development Developmental Process
Tagcloud ?		500k 9x10 affymetrix agp alleles anril atherosclerosis cad camta1 conjoint depth genotyping german highlighted illumina immunochip largest loci periodontitis plasminogen plg replicated rs2679895 rs4252120 sets shared vamp3 worldwide	arrays bid bmp2 bmpr1a clustering footprints genechip hybridized infarct ingenuity ipa ligation lmna mi myocardial myocardium nfkbia ninety pathophysiological porcine probe qrt remodelling remote sacrificed sets smad1 tgfb3 tnfrsf1a
Tagcloud (Difference) ?		500k 9x10 affymetrix agp alleles anril atherosclerosis cad camta1 conjoint depth genotyping german highlighted illumina immunochip largest loci periodontitis plasminogen plg replicated rs2679895 rs4252120 shared vamp3 worldwide	arrays bid bmp2 bmpr1a clustering footprints genechip hybridized infarct ingenuity ipa ligation lmna mi myocardial myocardium nfkbia ninety pathophysiological porcine probe qrt remodelling remote sacrificed smad1 tgfb3 tnfrsf1a
Tagcloud (Intersection) ?		sets