TGFBRAP1 and BMPR1A

Number of citations of the paper that reports this interaction (PMID 11278302)
8

Data Source:
HPRD (in vivo)

		TGFBRAP1	BMPR1A
Gene Name		transforming growth factor, beta receptor associated protein 1	bone morphogenetic protein receptor, type IA
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Membrane	Plasma Membrane Caveola Integral Component Of Membrane Dendrite Neuronal Cell Body
	Molecular Function	Small GTPase Regulator Activity Transforming Growth Factor Beta Receptor Binding Protein Binding SMAD Binding	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Protein Homodimerization Activity SMAD Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription, DNA-templated Intracellular Protein Transport Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Vesicle-mediated Transport Regulation Of Catalytic Activity	In Utero Embryonic Development Mesoderm Formation Somitogenesis Mullerian Duct Regression Positive Regulation Of Mesenchymal Cell Proliferation Endocardial Cushion Formation Transcription From RNA Polymerase II Promoter Protein Phosphorylation Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Ectoderm Development Dorsal/ventral Axis Specification Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Neural Crest Cell Development Stem Cell Maintenance Pituitary Gland Development Neural Plate Mediolateral Regionalization Signal Transduction By Phosphorylation Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Hindlimb Morphogenesis Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Paraxial Mesoderm Structural Organization Lateral Mesoderm Development Regulation Of Lateral Mesodermal Cell Fate Specification Mesendoderm Development Embryonic Organ Development Developmental Growth Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Neurogenesis Cartilage Development Palate Development Positive Regulation Of SMAD Protein Import Into Nucleus Heart Formation Regulation Of Cellular Senescence
Pathways			Signaling by BMP
Drugs
Diseases
GWAS		AIDS ( 19754311) Obesity-related traits ( 23251661) Preeclampsia ( 23551011)
Protein-Protein Interactions		9 interactors: ACVR1B ACVR2B ACVRL1 ALOX5 BMPR1A SMAD2 SMAD4 TGFBR1 TGFBR2	23 interactors: ACVR1 BAMBI BMP2 BMP4 BMP5 BMP6 BMP7 BMPR1B BMPR2 FKBP1A FKBP1B GDF5 GDF6 GDF9 HOXC8 NEDD4 NEDD4L SF3B4 SMAD1 TAB1 TGFBRAP1 USP15 ZMYND11
Entrez ID		9392	657
HPRD ID		06948	03192
Ensembl ID		ENSG00000135966
Uniprot IDs		Q8WUH2	P36894
PDB IDs			1ES7 1REW 2GOO 2H62 2H64 2K3G 2QJ9 2QJA 2QJB 3NH7 3QB4
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Signaling Pathway Palate Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Enzyme Linked Receptor Protein Signaling Pathway In Utero Embryonic Development Signal Transduction By Phosphorylation Embryo Development Positive Regulation Of Protein Phosphorylation Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Positive Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Cardiovascular System Development Gastrulation Regulation Of Cell Differentiation Positive Regulation Of Protein Modification Process Positive Regulation Of SMAD Protein Import Into Nucleus Pattern Specification Process Tissue Development Heart Development Regulation Of SMAD Protein Import Into Nucleus BMP Signaling Pathway Regulation Of Protein Phosphorylation Intracellular Signal Transduction Epithelium Development Anterior/posterior Pattern Specification Cellular Response To Growth Factor Stimulus Positive Regulation Of Cellular Protein Metabolic Process Response To Growth Factor Embryonic Morphogenesis Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Phosphorylation Tube Development Response To Cholesterol Protein Phosphorylation Regulation Of Activin Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Mesoderm Development Positive Regulation Of Cellular Metabolic Process Tube Morphogenesis Positive Regulation Of BMP Signaling Pathway Regulation Of Signal Transduction	Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Signal Transduction Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Cartilage Development Positive Regulation Of Bone Mineralization Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Positive Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signaling Cartilage Development Cell Surface Receptor Signaling Pathway Regulation Of RNA Metabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Neuron Differentiation Regulation Of Osteoblast Differentiation Regulation Of Signal Transduction Positive Regulation Of Cell Development Regulation Of Bone Mineralization Positive Regulation Of Protein Metabolic Process Connective Tissue Development Regulation Of Gene Expression Regulation Of Neuron Differentiation Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cartilage Development Regulation Of Transcription, DNA-templated Positive Regulation Of Neurogenesis Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of Cell Development Regulation Of Phosphorus Metabolic Process Regulation Of Ossification Positive Regulation Of Protein Modification Process Growth Regulation Of Neurogenesis Regulation Of Cell Differentiation Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Response To Organic Substance Skeletal System Development
Tagcloud ?		500k 9x10 affymetrix agp alleles anril atherosclerosis cad camta1 conjoint depth genotyping german highlighted illumina immunochip largest loci periodontitis plasminogen plg replicated rs2679895 rs4252120 sets shared vamp3 worldwide	abundant adenomatosis apcdd1 bmp5 closure destinies dictated dkk2 e15 edge eyelid eyelids fetuses fgfr2 gli2 identities ie jag1 lcm le microdissection morphogenetic notch1 opening polyposis ptch1 shh smo tip
Tagcloud (Difference) ?		500k 9x10 affymetrix agp alleles anril atherosclerosis cad camta1 conjoint depth genotyping german highlighted illumina immunochip largest loci periodontitis plasminogen plg replicated rs2679895 rs4252120 sets shared vamp3 worldwide	abundant adenomatosis apcdd1 bmp5 closure destinies dictated dkk2 e15 edge eyelid eyelids fetuses fgfr2 gli2 identities ie jag1 lcm le microdissection morphogenetic notch1 opening polyposis ptch1 shh smo tip
Tagcloud (Intersection) ?