SLC4A8 and CFTR

Number of citations of the paper that reports this interaction (PMID 12403779)
19

Data Source:
HPRD (in vivo)

		SLC4A8	CFTR
Gene Name		solute carrier family 4, sodium bicarbonate cotransporter, member 8	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Neuronal Cell Body Membrane Neuron Projection	Cytoplasm Early Endosome Plasma Membrane Microvillus Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Cytoplasmic Vesicle Membrane Endoplasmic Reticulum Sec Complex Early Endosome Membrane Chloride Channel Complex Protein Complex Recycling Endosome Extracellular Vesicular Exosome
	Molecular Function	Inorganic Anion Exchanger Activity Sodium:bicarbonate Symporter Activity	ATP-binding And Phosphorylation-dependent Chloride Channel Activity Chloride Channel Activity Channel-conductance-controlling ATPase Activity Protein Binding ATP Binding Bicarbonate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Chloride Channel Inhibitor Activity Enzyme Binding PDZ Domain Binding
	Biological Process	Ion Transport Bicarbonate Transport Sodium Ion Transmembrane Transport Regulation Of Intracellular PH Transmembrane Transport Anion Transmembrane Transport	Cholesterol Biosynthetic Process Transport Water Transport Respiratory Gaseous Exchange Bicarbonate Transport Iodide Transport Cholesterol Transport Transepithelial Chloride Transport Lung Development Cellular Response To Hormone Stimulus Response To Cytokine Vasodilation Response To Drug Response To Peptide Hormone Response To Estrogen Positive Regulation Of Vasodilation Sperm Capacitation Intracellular PH Elevation Transmembrane Transport Membrane Hyperpolarization Cellular Response To CAMP Chloride Transmembrane Transport Positive Regulation Of Voltage-gated Chloride Channel Activity
Pathways		Transport of inorganic cations/anions and amino acids/oligopeptides SLC-mediated transmembrane transport Bicarbonate transporters	ABC-family proteins mediated transport
Drugs			Bumetanide Glyburide Ibuprofen Adenosine-5\'-Diphosphate Phosphoaminophosphonic Acid-Adenylate Ester Phosphonoserine Crofelemer Ivacaftor
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033)	Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573)
Protein-Protein Interactions		3 interactors: CA2 CFTR SLC9A3R1	28 interactors: CANX CLCN3 DERL1 DNAJA1 DNAJC5 EZR GOPC HSP90AA1 NHS PDZD3 PDZK1 PPP2R1B PRKAA1 PRKACA PRKAR2A PRKCA PRKCE PRKG1 RNF5 SLC4A7 SLC4A8 SLC9A3R1 SLC9A3R2 SLC9A6 SNAP23 STX1A UBC UBE2I
Entrez ID		9498	1080
HPRD ID		05430	03883
Ensembl ID		ENSG00000050438	ENSG00000001626
Uniprot IDs		B4DHY0 E7EML0 F5GZ31 Q2Y0W8	P13569
PDB IDs			1NBD 1XMI 1XMJ 2BBO 2BBS 2BBT 2LOB 2PZE 2PZF 2PZG 3GD7 3ISW
Enriched GO Terms of Interacting Partners?		Regulation Of Chloride Transport Bicarbonate Transport Organic Anion Transport Cellular Ion Homeostasis Regulation Of Intracellular PH Regulation Of Cellular PH Cellular Chemical Homeostasis Ion Homeostasis Regulation Of Ion Transport Anion Transport Cellular Homeostasis Regulation Of PH Chemical Homeostasis Regulation Of Anion Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Renal Phosphate Ion Absorption Positive Regulation Of Voltage-gated Chloride Channel Activity Homeostatic Process Response To Estrogen Positive Regulation Of Dipeptide Transmembrane Transport Negative Regulation Of Sodium:proton Antiporter Activity Glutathione Transport Ion Transport Positive Regulation Of Cellular PH Reduction Lipid Transport Lipid Localization Renal Sodium Ion Transport Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Iodide Transport Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Negative Regulation Of Sodium Ion Transmembrane Transport Angiotensin-activated Signaling Pathway Transepithelial Chloride Transport Regulation Of Ion Transmembrane Transport Phospholipase C-activating Dopamine Receptor Signaling Pathway Cellular Cation Homeostasis Response To Steroid Hormone Bile Acid Secretion Oligopeptide Transport Negative Regulation Of Sodium Ion Transport Renal Absorption Regulation Of Proton Transport Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Transepithelial Transport Intracellular PH Elevation Phosphate Ion Homeostasis Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Positive Regulation Of Synaptic Transmission, GABAergic	Chemical Homeostasis Ion Homeostasis Transport Homeostatic Process Negative Regulation Of Glucose Import Activation Of Phospholipase C Activity Regulation Of Protein Transport Enzyme Linked Receptor Protein Signaling Pathway Energy Reserve Metabolic Process Positive Regulation Of Phospholipase C Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Ion Homeostasis Regulation Of Establishment Of Protein Localization Regulation Of Catalytic Activity Cellular Localization Regulation Of Platelet Aggregation Negative Regulation Of Glucose Transport Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Dense Core Granule Biogenesis Regulation Of PH Positive Regulation Of Phospholipase Activity Cellular Chemical Homeostasis Ion Transport Regulation Of Protein Localization Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Negative Regulation Of Lyase Activity Regulation Of Phospholipase Activity Regulation Of Insulin Secretion Positive Regulation Of Lipase Activity Histone H3-T6 Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Regulation Of Peptide Hormone Secretion Negative Regulation Of Transport Regulation Of MAPK Cascade Neurotrophin Signaling Pathway Synaptic Vesicle Transport Regulation Of Platelet Activation Negative Regulation Of Intracellular Signal Transduction Anion Transport Cellular Cation Homeostasis Peptidyl-serine Phosphorylation Inorganic Anion Transport Cellular Homeostasis Regulation Of Hormone Secretion Regulation Of Signaling Negative Regulation Of Nucleotide Metabolic Process Regulation Of Wound Healing
Tagcloud ?		adaptive beginning cb cch cerebellum cx decreases durations exchanger exhibits hc hco hypothesize nbcn1 nbcn2 ncbt ncbts ndcbe neonates normoxia p2 p90 polyclonal pyramidal rodent scx stabilizes subcortex transporters	aberrantly carrying considerable correctly correlates cryptic cystic epithelium exon fev1 fibrosis insufficiency inverse kb nasal nondifferential penetrance pulmonary rna semiquantitative severity splice spliced splicing transcribed transcripts variability varies
Tagcloud (Difference) ?		adaptive beginning cb cch cerebellum cx decreases durations exchanger exhibits hc hco hypothesize nbcn1 nbcn2 ncbt ncbts ndcbe neonates normoxia p2 p90 polyclonal pyramidal rodent scx stabilizes subcortex transporters	aberrantly carrying considerable correctly correlates cryptic cystic epithelium exon fev1 fibrosis insufficiency inverse kb nasal nondifferential penetrance pulmonary rna semiquantitative severity splice spliced splicing transcribed transcripts variability varies
Tagcloud (Intersection) ?