SLC4A7 and CFTR

Number of citations of the paper that reports this interaction (PMID 12403779)
19

Data Source:
HPRD (in vitro, in vivo)

		SLC4A7	CFTR
Gene Name		solute carrier family 4, sodium bicarbonate cotransporter, member 7	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Stereocilium	Cytoplasm Early Endosome Plasma Membrane Microvillus Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Cytoplasmic Vesicle Membrane Endoplasmic Reticulum Sec Complex Early Endosome Membrane Chloride Channel Complex Protein Complex Recycling Endosome Extracellular Vesicular Exosome
	Molecular Function	Inorganic Anion Exchanger Activity Sodium:bicarbonate Symporter Activity	ATP-binding And Phosphorylation-dependent Chloride Channel Activity Chloride Channel Activity Channel-conductance-controlling ATPase Activity Protein Binding ATP Binding Bicarbonate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Chloride Channel Inhibitor Activity Enzyme Binding PDZ Domain Binding
	Biological Process	Ion Transport Bicarbonate Transport Cochlear Nucleus Development Sodium Ion Transmembrane Transport Retinal Cell Programmed Cell Death Regulation Of Intracellular PH Transmembrane Transport Auditory Receptor Cell Development Retina Vasculature Morphogenesis In Camera-type Eye Anion Transmembrane Transport	Cholesterol Biosynthetic Process Transport Water Transport Respiratory Gaseous Exchange Bicarbonate Transport Iodide Transport Cholesterol Transport Transepithelial Chloride Transport Lung Development Cellular Response To Hormone Stimulus Response To Cytokine Vasodilation Response To Drug Response To Peptide Hormone Response To Estrogen Positive Regulation Of Vasodilation Sperm Capacitation Intracellular PH Elevation Transmembrane Transport Membrane Hyperpolarization Cellular Response To CAMP Chloride Transmembrane Transport Positive Regulation Of Voltage-gated Chloride Channel Activity
Pathways		Transport of inorganic cations/anions and amino acids/oligopeptides SLC-mediated transmembrane transport Bicarbonate transporters	ABC-family proteins mediated transport
Drugs			Bumetanide Glyburide Ibuprofen Adenosine-5\'-Diphosphate Phosphoaminophosphonic Acid-Adenylate Ester Phosphonoserine Crofelemer Ivacaftor
Diseases
GWAS		Blood pressure ( 21909110) Breast cancer ( 21263130 23535729 20453838) Diastolic blood pressure ( 21909115) Systolic blood pressure ( 21909115)	Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573)
Protein-Protein Interactions		3 interactors: CFTR SLC4A4 YWHAB	28 interactors: CANX CLCN3 DERL1 DNAJA1 DNAJC5 EZR GOPC HSP90AA1 NHS PDZD3 PDZK1 PPP2R1B PRKAA1 PRKACA PRKAR2A PRKCA PRKCE PRKG1 RNF5 SLC4A7 SLC4A8 SLC9A3R1 SLC9A3R2 SLC9A6 SNAP23 STX1A UBC UBE2I
Entrez ID		9497	1080
HPRD ID		04521	03883
Ensembl ID		ENSG00000033867	ENSG00000001626
Uniprot IDs		E9PFN4 Q9Y6M7	P13569
PDB IDs			1NBD 1XMI 1XMJ 2BBO 2BBS 2BBT 2LOB 2PZE 2PZF 2PZG 3GD7 3ISW
Enriched GO Terms of Interacting Partners?		Bicarbonate Transport Regulation Of Intracellular PH Regulation Of Cellular PH Regulation Of PH Positive Regulation Of Voltage-gated Chloride Channel Activity Inorganic Anion Transport Regulation Of Chloride Transport Negative Regulation Of Protein Dephosphorylation Iodide Transport Anion Transmembrane Transport Transepithelial Chloride Transport Organic Anion Transport Cellular Cation Homeostasis Cellular Ion Homeostasis Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Cellular Chemical Homeostasis Transepithelial Transport Intracellular PH Elevation Ion Homeostasis Cellular Response To Hormone Stimulus Sperm Capacitation Anion Transport Cellular Homeostasis Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Transport Cytoplasmic Sequestering Of Protein Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Hippo Signaling Response To Organonitrogen Compound Chemical Homeostasis Positive Regulation Of Vasodilation Vasodilation Cholesterol Biosynthetic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Membrane Hyperpolarization Response To Hormone Sterol Biosynthetic Process Water Transport Regulation Of Vasodilation Fluid Transport Cellular Response To CAMP Positive Regulation Of Ion Transmembrane Transporter Activity Respiratory Gaseous Exchange Positive Regulation Of Transporter Activity Positive Regulation Of Mitochondrion Organization Activation Of MAPKK Activity Sterol Transport Cholesterol Transport	Chemical Homeostasis Ion Homeostasis Transport Homeostatic Process Negative Regulation Of Glucose Import Activation Of Phospholipase C Activity Regulation Of Protein Transport Enzyme Linked Receptor Protein Signaling Pathway Energy Reserve Metabolic Process Positive Regulation Of Phospholipase C Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Ion Homeostasis Regulation Of Establishment Of Protein Localization Regulation Of Catalytic Activity Cellular Localization Regulation Of Platelet Aggregation Negative Regulation Of Glucose Transport Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Dense Core Granule Biogenesis Regulation Of PH Positive Regulation Of Phospholipase Activity Cellular Chemical Homeostasis Ion Transport Regulation Of Protein Localization Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Negative Regulation Of Lyase Activity Regulation Of Phospholipase Activity Regulation Of Insulin Secretion Positive Regulation Of Lipase Activity Histone H3-T6 Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Regulation Of Peptide Hormone Secretion Negative Regulation Of Transport Regulation Of MAPK Cascade Neurotrophin Signaling Pathway Synaptic Vesicle Transport Regulation Of Platelet Activation Negative Regulation Of Intracellular Signal Transduction Anion Transport Cellular Cation Homeostasis Peptidyl-serine Phosphorylation Inorganic Anion Transport Cellular Homeostasis Regulation Of Hormone Secretion Regulation Of Signaling Negative Regulation Of Nucleotide Metabolic Process Regulation Of Wound Healing
Tagcloud ?		atpases bicarbonate cotransporter dense diffusive dissected dysregulation electroneutral equivalents exchanger flux freshly hco hypothesize microenvironment nbcn1 nhe1 origins perfused proton publicly reflecting reflects slc26 slc9a1 summarize transporters unifying	aberrantly carrying considerable correctly correlates cryptic cystic epithelium exon fev1 fibrosis insufficiency inverse kb nasal nondifferential penetrance pulmonary rna semiquantitative severity splice spliced splicing transcribed transcripts variability varies
Tagcloud (Difference) ?		atpases bicarbonate cotransporter dense diffusive dissected dysregulation electroneutral equivalents exchanger flux freshly hco hypothesize microenvironment nbcn1 nhe1 origins perfused proton publicly reflecting reflects slc26 slc9a1 summarize transporters unifying	aberrantly carrying considerable correctly correlates cryptic cystic epithelium exon fev1 fibrosis insufficiency inverse kb nasal nondifferential penetrance pulmonary rna semiquantitative severity splice spliced splicing transcribed transcripts variability varies
Tagcloud (Intersection) ?