SLC4A7 and SLC4A4

Number of citations of the paper that reports this interaction (PMID 10600945)
6

Data Source:
HPRD (in vivo)

		SLC4A7	SLC4A4
Gene Name		solute carrier family 4, sodium bicarbonate cotransporter, member 7	solute carrier family 4 (sodium bicarbonate cotransporter), member 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Stereocilium	Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Inorganic Anion Exchanger Activity Sodium:bicarbonate Symporter Activity	Inorganic Anion Exchanger Activity Protein Binding Sodium:bicarbonate Symporter Activity
	Biological Process	Ion Transport Bicarbonate Transport Cochlear Nucleus Development Sodium Ion Transmembrane Transport Retinal Cell Programmed Cell Death Regulation Of Intracellular PH Transmembrane Transport Auditory Receptor Cell Development Retina Vasculature Morphogenesis In Camera-type Eye Anion Transmembrane Transport	Transport Ion Transport Bicarbonate Transport Sodium Ion Transmembrane Transport Regulation Of Intracellular PH Transmembrane Transport Anion Transmembrane Transport
Pathways		Transport of inorganic cations/anions and amino acids/oligopeptides SLC-mediated transmembrane transport Bicarbonate transporters	Transport of inorganic cations/anions and amino acids/oligopeptides SLC-mediated transmembrane transport Bicarbonate transporters
Drugs
Diseases
GWAS		Blood pressure ( 21909110) Breast cancer ( 21263130 23535729 20453838) Diastolic blood pressure ( 21909115) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		3 interactors: CFTR SLC4A4 YWHAB	5 interactors: CA2 CA4 PRKACA SLC4A7 SREBF2
Entrez ID		9497	8671
HPRD ID		04521	04516
Ensembl ID		ENSG00000033867	ENSG00000080493
Uniprot IDs		E9PFN4 Q9Y6M7	A5JJ20 Q9Y6R1
PDB IDs
Enriched GO Terms of Interacting Partners?		Bicarbonate Transport Regulation Of Intracellular PH Regulation Of Cellular PH Regulation Of PH Positive Regulation Of Voltage-gated Chloride Channel Activity Inorganic Anion Transport Regulation Of Chloride Transport Negative Regulation Of Protein Dephosphorylation Iodide Transport Anion Transmembrane Transport Transepithelial Chloride Transport Organic Anion Transport Cellular Cation Homeostasis Cellular Ion Homeostasis Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Cellular Chemical Homeostasis Transepithelial Transport Intracellular PH Elevation Ion Homeostasis Cellular Response To Hormone Stimulus Sperm Capacitation Anion Transport Cellular Homeostasis Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Transport Cytoplasmic Sequestering Of Protein Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Hippo Signaling Response To Organonitrogen Compound Chemical Homeostasis Positive Regulation Of Vasodilation Vasodilation Cholesterol Biosynthetic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Membrane Hyperpolarization Response To Hormone Sterol Biosynthetic Process Water Transport Regulation Of Vasodilation Fluid Transport Cellular Response To CAMP Positive Regulation Of Ion Transmembrane Transporter Activity Respiratory Gaseous Exchange Positive Regulation Of Transporter Activity Positive Regulation Of Mitochondrion Organization Activation Of MAPKK Activity Sterol Transport Cholesterol Transport	Bicarbonate Transport Cellular Response To Fluid Shear Stress Response To Fluid Shear Stress One-carbon Metabolic Process Regulation Of Intracellular PH Regulation Of Cellular PH Positive Regulation Of Myeloid Leukocyte Differentiation Organic Anion Transport Cellular Cation Homeostasis Cellular Ion Homeostasis Regulation Of PH Positive Regulation Of Myeloid Cell Differentiation Cellular Chemical Homeostasis Ion Homeostasis Positive Regulation Of Dense Core Granule Biogenesis Anion Transport Regulation Of Myeloid Leukocyte Differentiation Cellular Homeostasis Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Histone H3-T6 Phosphorylation Positive Regulation Of Dipeptide Transmembrane Transport Small Molecule Metabolic Process Chemical Homeostasis Regulation Of Ion Homeostasis Response To Organic Cyclic Compound Regulation Of Myeloid Cell Differentiation Response To Organic Substance Response To Hormone Cochlear Nucleus Development Positive Regulation Of Cellular PH Reduction Retinal Cell Programmed Cell Death Regulation Of Chloride Transport Epithelium Development Negative Regulation Of Cholesterol Efflux Organ Development Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Cellular Response To Laminar Fluid Shear Stress Angiotensin-activated Signaling Pathway Regulation Of Synaptic Transmission Homeostatic Process Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Tight Junction Assembly Negative Regulation Of Cholesterol Transport Negative Regulation Of Glucose Import Positive Regulation Of Macrophage Differentiation Pons Development
Tagcloud ?		atpases bicarbonate cotransporter dense diffusive dissected dysregulation electroneutral equivalents exchanger flux freshly hco hypothesize microenvironment nbcn1 nhe1 origins perfused proton publicly reflecting reflects slc26 slc9a1 summarize transporters unifying	bmp cacna1d ccl2 cd25 cd26 cdkn1a cml cure dpp4 dusp12 dysregulation eradication exploited il1rap il2ra kcnk5 lscs marcks microarrays mycn oncogenes perp persistence ptprd refined timeless tki transcriptome withdrawal
Tagcloud (Difference) ?		atpases bicarbonate cotransporter dense diffusive dissected electroneutral equivalents exchanger flux freshly hco hypothesize microenvironment nbcn1 nhe1 origins perfused proton publicly reflecting reflects slc26 slc9a1 summarize transporters unifying	bmp cacna1d ccl2 cd25 cd26 cdkn1a cml cure dpp4 dusp12 eradication exploited il1rap il2ra kcnk5 lscs marcks microarrays mycn oncogenes perp persistence ptprd refined timeless tki transcriptome withdrawal
Tagcloud (Intersection) ?		dysregulation