P2RY1 and ADORA1

Number of citations of the paper that reports this interaction (PubMedID 11390975)
37

Data Source:
HPRD (in vivo)

		P2RY1	ADORA1
Description		purinergic receptor P2Y1	adenosine A1 receptor
Image
GO Annotations	Cellular Component	Plasma Membrane Cilium Cell Surface Postsynaptic Density Membrane Basolateral Plasma Membrane Apical Plasma Membrane Dendrite Cell Body Postsynaptic Membrane Presynaptic Active Zone Membrane Glutamatergic Synapse	Plasma Membrane Cilium Membrane Basolateral Plasma Membrane Dendrite Axolemma Asymmetric Synapse Presynaptic Membrane Neuronal Cell Body Terminal Bouton Dendritic Spine Cell Body Calyx Of Held Synapse Postsynaptic Membrane Presynaptic Active Zone
	Molecular Function	Nucleotide Binding G Protein-coupled ADP Receptor Activity G Protein-coupled Receptor Activity Protein Binding ATP Binding Signaling Receptor Regulator Activity A1 Adenosine Receptor Binding Signaling Receptor Activity ADP Binding G Protein-coupled Purinergic Nucleotide Receptor Activity G Protein-coupled ATP Receptor Activity Protein Heterodimerization Activity Scaffold Protein Binding	G Protein-coupled Adenosine Receptor Activity G Protein-coupled Receptor Binding Purine Nucleoside Binding G Protein-coupled Receptor Activity Protein Binding Heat Shock Protein Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Binding Protein-containing Complex Binding Protein Heterodimerization Activity
	Biological Process	G Protein-coupled Adenosine Receptor Signaling Pathway Monoatomic Ion Transport Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Hemostasis Glial Cell Migration Regulation Of Cell Shape Response To Mechanical Stimulus Negative Regulation Of Norepinephrine Secretion Signal Transduction Involved In Regulation Of Gene Expression Platelet Activation Positive Regulation Of Inositol Trisphosphate Biosynthetic Process G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway Eating Behavior Positive Regulation Of Monoatomic Ion Transport Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hormone Secretion Establishment Of Localization In Cell Positive Regulation Of Penile Erection Positive Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor Cellular Response To ATP Cellular Response To Purine-containing Compound Protein Localization To Plasma Membrane Relaxation Of Muscle Blood Vessel Diameter Maintenance Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Synaptic Vesicle Exocytosis	Temperature Homeostasis Response To Hypoxia G Protein-coupled Adenosine Receptor Signaling Pathway Regulation Of Respiratory Gaseous Exchange By Nervous System Process Negative Regulation Of Acute Inflammatory Response Negative Regulation Of Leukocyte Migration Positive Regulation Of Peptide Secretion Positive Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Systemic Arterial Blood Pressure Regulation Of Glomerular Filtration Protein Targeting To Membrane Phagocytosis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Nervous System Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Glutamate Secretion Response To Purine-containing Compound Lipid Catabolic Process Negative Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Nucleoside Transport Negative Regulation Of Neurotrophin Production Positive Regulation Of Dephosphorylation G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway Vasodilation Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Apoptotic Process Positive Regulation Of Potassium Ion Transport Positive Regulation Of MAPK Cascade Negative Regulation Of Blood Pressure Positive Regulation Of Blood Pressure Negative Regulation Of Hormone Secretion Negative Regulation Of Inflammatory Response Cognition Leukocyte Migration Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Catabolic Process Regulation Of Sensory Perception Of Pain Negative Regulation Of Synaptic Transmission, Glutamatergic Fatty Acid Homeostasis Regulation Of Cardiac Muscle Contraction Excitatory Postsynaptic Potential Long-term Synaptic Depression Mucus Secretion Negative Regulation Of Mucus Secretion Triglyceride Homeostasis Regulation Of Cardiac Muscle Cell Contraction Apoptotic Signaling Pathway Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Long-term Synaptic Depression
Pathways		G alpha (q) signalling events P2Y receptors ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1	Adenosine P1 receptors G alpha (i) signalling events
Drugs		Promethazine	Tramadol Caffeine Theophylline Lamotrigine Adenosine Dyphylline Pentoxifylline Enprofylline Gabapentin Aminophylline Oxtriphylline Theobromine Defibrotide Tecadenoson Naxifylline Cannabidiol Istradefylline Tonapofylline Rolofylline
Diseases
GWAS		Body mass index (change over time) in gastrointestinal cancer or chronic obstructive pulmonary disease ( 28044437) Chronotype ( 30696823) Immune reponse to smallpox (secreted IL-2) ( 22610502) Metabolite levels ( 23823483) Serum sulfate level ( 27412988)	Asthma ( 27182965 30929738 31361310 31619474 31959851 32296059) Asthma (childhood onset) ( 30929738 31036433) Clozapine-induced agranulocytosis ( 25187353) Systolic blood pressure ( 30224653) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		3 interacting genes: ADORA1 NHERF1 NHERF2	12 interacting genes: ADA ATXN1L DRD1 EPB41L2 GNAI2 GNAO1 GNAS GNAZ GRM1 P2RY1 SNF8 TSHR
Entrez ID		5028	134
HPRD ID		03103	00042
Ensembl ID		ENSG00000169860	ENSG00000163485
Uniprot IDs		P47900	B7Z1L9 B7Z379 P30542
PDB IDs		4XNV 4XNW 7XXH 8WJX	5N2S 5UEN 6D9H 7LD3 7LD4
Enriched GO Terms of Interacting Partners?		Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Endomembrane System Protein-membrane Adaptor Activity Phosphatase Binding Localization Within Membrane Positive Regulation Of Nucleoside Transport Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Beta-catenin Binding Renal Phosphate Ion Absorption Renal System Process Negative Regulation Of Mucus Secretion Purine Nucleoside Binding Negative Regulation Of Neurotrophin Production Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Respiratory Gaseous Exchange By Nervous System Process Negative Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Amino Acid Transport G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway Regulation Of Respiratory System Process Regulation Of Mucus Secretion Heterotrimeric G-protein Binding Regulation Of Long-term Synaptic Depression Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Cellular Localization Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Acute Inflammatory Response Vascular Process In Circulatory System Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Cell Motility Negative Regulation Of Locomotion G Protein-coupled Adenosine Receptor Activity Negative Regulation Of Cell Migration Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Asymmetric Synapse Negative Regulation Of Long-term Synaptic Depression Regulation Of Glomerular Filtration Mucus Secretion Axolemma Regulation Of Metal Ion Transport Circulatory System Process Inorganic Ion Homeostasis Positive Regulation Of Dephosphorylation Negative Regulation Of Glutamate Secretion Regulation Of Monoatomic Ion Transport Negative Regulation Of Synaptic Transmission, GABAergic Negative Regulation Of Circadian Rhythm G Protein-coupled Adenosine Receptor Signaling Pathway	Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Heterotrimeric G-protein Complex Dendrite G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Secretion Regulation Of Secretion Cell Body G Protein-coupled Dopamine Receptor Signaling Pathway Mu-type Opioid Receptor Binding Plasma Membrane G Protein-coupled Serotonin Receptor Binding Regulation Of Secretion By Cell System Process Corticotropin-releasing Hormone Receptor 1 Binding Adenylate Cyclase Regulator Activity Negative Regulation Of Secretion By Cell Regulation Of Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Transport Regulation Of Biological Quality Modulation Of Chemical Synaptic Transmission Postsynaptic Membrane G Protein-coupled Adenosine Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Muscle System Process Regulation Of Hormone Secretion Regulation Of Body Fluid Levels Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway GTPase Activity Cellular Response To Catecholamine Stimulus Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Response To Catecholamine G Protein-coupled Serotonin Receptor Signaling Pathway Adrenergic Receptor Signaling Pathway Purinergic Nucleotide Receptor Signaling Pathway GTP Binding G Protein-coupled Receptor Activity Regulation Of Insulin Secretion Positive Regulation Of MAPK Cascade Regulation Of Exocytosis Locomotory Behavior Negative Regulation Of Synaptic Transmission Regulation Of Peptide Hormone Secretion Muscle Contraction Negative Regulation Of Insulin Secretion Regulation Of Hormone Levels Negative Regulation Of Peptide Secretion
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