P2RY1

Gene Name		purinergic receptor P2Y, G-protein coupled, 1
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Gene Ontology Annotations	Cellular Component	Mitochondrion Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Dendrite Cell Body Postsynaptic Membrane Neuronal Postsynaptic Density
	Molecular Function	Receptor Activity Protein Binding ATP Binding A1 Adenosine Receptor Binding ADP Binding G-protein Coupled Purinergic Nucleotide Receptor Activity ATP-activated Nucleotide Receptor Activity ADP-activated Nucleotide Receptor Activity Protein Heterodimerization Activity Scaffold Protein Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Adenosine Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Aging Blood Coagulation Response To Mechanical Stimulus Regulation Of Receptor Activity Negative Regulation Of Norepinephrine Secretion Sensory Perception Of Pain Signal Transduction Involved In Regulation Of Gene Expression Platelet Activation Positive Regulation Of Inositol Trisphosphate Biosynthetic Process G-protein Coupled Purinergic Nucleotide Receptor Signaling Pathway Regulation Of Vasodilation Eating Behavior Positive Regulation Of Ion Transport Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hormone Secretion Negative Regulation Of Binding Positive Regulation Of Penile Erection Positive Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor Protein Localization To Plasma Membrane Relaxation Of Muscle
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR ADP signalling through P2Y purinoceptor 1 Nucleotide-like (purinergic) receptors Class A/1 (Rhodopsin-like receptors) Signal amplification Metabolic disorders of biological oxidation enzymes GPCR ligand binding P2Y receptors G alpha (q) signalling events GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS		Immune reponse to smallpox (secreted IL-2) ( 22610502)
Protein-protein Interactions		3 interactors: ADORA1 SLC9A3R1 SLC9A3R2
Entrez ID		5028
HPRD ID		03103
Ensembl ID		ENSG00000169860
Uniprot IDs		P47900
PDB IDs		1Y36
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Excretion Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Ion Transport Renal System Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Negative Regulation Of Long Term Synaptic Depression Renal Phosphate Ion Absorption Negative Regulation Of Neurotrophin Production Positive Regulation Of Nucleoside Transport Negative Regulation Of Signaling Negative Regulation Of Cell Migration Negative Regulation Of Mucus Secretion Negative Regulation Of Sodium:proton Antiporter Activity Glutathione Transport Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Cell Motility Negative Regulation Of Cellular Component Movement Negative Regulation Of Locomotion Regulation Of Long Term Synaptic Depression Regulation Of Intracellular Signal Transduction Renal Sodium Ion Transport Negative Regulation Of Cardiac Muscle Contraction Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Glutamate Secretion Negative Regulation Of Renal Sodium Excretion Negative Regulation Of Transport Negative Regulation Of Vasodilation Negative Regulation Of Striated Muscle Contraction Negative Regulation Of Synaptic Transmission, GABAergic Negative Regulation Of Intracellular Signal Transduction Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Relaxation Of Vascular Smooth Muscle Bile Acid Secretion Relaxation Of Smooth Muscle Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Oligopeptide Transport Negative Regulation Of Sodium Ion Transport Renal Absorption Regulation Of Proton Transport Regulation Of Glutamate Secretion Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Adenosine Receptor Signaling Pathway Regulation Of Glomerular Filtration
Tagcloud ?		bipolar bpd creb1 dd depressed depression depressive dysregulation examining females financial hpa lesser leukocytes mdd medication nfkb1 nr3c1 oxtr p2rx1 p2rx7 purinergic qpcr refractory replicated served sparc trpv1 trpv4