TRIP10 and WAS

Number of citations of the paper that reports this interaction (PubMedID 10713100)
0

Data Source:
HPRD (two hybrid, in vitro)

		TRIP10	WAS
Description		thyroid hormone receptor interactor 10	WASP actin nucleation promoting factor
Image
GO Annotations	Cellular Component	Phagocytic Cup Nucleoplasm Cytoplasm Lysosome Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Cell Cortex Membrane Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome	Nucleus Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Cell-cell Junction Vesicle Membrane Actin Cytoskeleton Membrane Site Of Double-strand Break Phagocytic Vesicle Extracellular Exosome
	Molecular Function	Protein Binding Lipid Binding Identical Protein Binding	Actin Binding Protein Binding SH3 Domain Binding Protein Kinase Binding GTPase Regulator Activity Small GTPase Binding Identical Protein Binding Phospholipase Binding
	Biological Process	Endocytosis Cell Communication Signal Transduction Actin Cytoskeleton Organization	Regulation Of T Cell Antigen Processing And Presentation Defense Response Immune Response Actin Filament Organization Rho Protein Signal Transduction Blood Coagulation Regulation Of Actin Polymerization Or Depolymerization Actin Polymerization Or Depolymerization Epidermis Development Regulation Of Lamellipodium Assembly Endosomal Transport Actin Filament Polymerization Actin Filament-based Movement Cdc42 Protein Signal Transduction T Cell Activation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Protein-containing Complex Assembly Cellular Response To Type II Interferon Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Cell Motility Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Clathrin-mediated endocytosis RHOQ GTPase cycle	Generation of second messenger molecules Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs CDC42 GTPase cycle RAC1 GTPase cycle RHOJ GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs			(S)-wiskostatin
Diseases			Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM) Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS			Platelet distribution width ( 32888494)
Interacting Genes		43 interacting genes: ABI1 ABL2 AKAP9 ARHGAP12 ARHGAP17 CDC42 CREBBP CTNNB1 DNM2 DTX3 HOXC11 HTT JRK LYN MEOX1 MEOX2 NKX2-5 PAX6 PDE6G POT1 PRKACA RHOJ RHOQ RIN1 RXRA SF3A2 SH3BP1 SHANK3 SMARCE1 SMURF1 SRC STAT3 TERF1 THAP1 THRB TINF2 UTF1 WAS WASF1 WASL WBP11 WWP2 ZBTB7B	61 interacting genes: ABI3 ACTC1 ACTR2 APBB1 APPBP2 ARHGAP1 ARHGEF7 ARPC1B ARPC2 ARPC3 BAIAP2L1 BTK C5AR1 CDC42 CIB1 CREBBP CRKL CSNK2A1 CSNK2A2 DLG1 DVL2 ENAH EVL FCHSD2 FGR FYB1 FYN GRB2 HCK HCLS1 ITK ITSN2 LCK LCP2 NCK1 NCK2 NCKIPSD PIK3R1 PLCG1 PRPF40A PSTPIP1 PTPN12 RAC1 RANBP2 RGS14 RHOJ RPA1 RPA2 RPA3 SNX9 SORBS2 SRC TCERG1 TEC TNK2 TRIP10 UBASH3A VASP WBP4 WIPF1 WIPF2
Entrez ID		9322	7454
HPRD ID		05142	02314
Ensembl ID		ENSG00000125733	ENSG00000015285
Uniprot IDs		Q15642 W4VSQ9	A0A8V8TM35 P42768
PDB IDs		2CT4 2EFK 2KE4	1CEE 1EJ5 1T84 2A3Z 2K42 2OT0
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Component Organization Actin Filament Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Component Organization Positive Regulation Of Metabolic Process Supramolecular Fiber Organization Positive Regulation Of Macromolecule Metabolic Process Regulation Of Organelle Organization SH3 Domain Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Cell Projection Organization Shelterin Complex Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Signal Transduction Regulation Of Cell Projection Organization Transcription By RNA Polymerase II Actin Filament-based Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Transmembrane Transporter Binding Nuclear Telomere Cap Complex Developmental Process Regulation Of Actin Cytoskeleton Organization Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Telomere Maintenance Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of Primary Metabolic Process Telomere Capping Signal Transduction Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Positive Regulation Of Signal Transduction Establishment Of Organelle Localization Regulation Of Telomere Maintenance Via Telomerase Regulation Of Cytoskeleton Organization Membrane Invagination Ectoderm Development Regulation Of Cell Communication Regulation Of Signaling Cell Projection Morphogenesis Positive Regulation Of DNA Metabolic Process Intracellular Signaling Cassette	Positive Regulation Of Actin Filament Polymerization Actin Filament Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Protein Polymerization Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Actin Filament Organization Regulation Of Supramolecular Fiber Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Lamellipodium Supramolecular Fiber Organization Immune Response-activating Signaling Pathway Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein-containing Complex Assembly Regulation Of Actin Filament-based Process Regulation Of Cytoskeleton Organization Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Supramolecular Fiber Organization Immune Response-regulating Signaling Pathway Activation Of Immune Response Positive Regulation Of Cytoskeleton Organization Regulation Of Cellular Component Size Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Cytosol Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway Cytoplasm Regulation Of Lamellipodium Organization Positive Regulation Of Cellular Component Organization Focal Adhesion Positive Regulation Of Immune System Process Regulation Of Cellular Component Organization Positive Regulation Of Lamellipodium Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Immune Response Cell Projection SH3 Domain Binding Regulation Of Immune System Process Phosphotyrosine Residue Binding Regulation Of Organelle Organization Regulation Of Immune Response Peptidyl-tyrosine Phosphorylation Intracellular Signal Transduction Signal Transduction Protein Tyrosine Kinase Activity Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization
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