TRIP10 and DNM2

Number of citations of the paper that reports this interaction (PMID 16418535)
97

Data Source:
BioGRID (pull down)

		TRIP10	DNM2
Gene Name		thyroid hormone receptor interactor 10	dynamin 2
Image
Gene Ontology Annotations	Cellular Component	Phagocytic Cup Nucleoplasm Cytoplasm Lysosome Golgi Apparatus Cytosol Cytoskeleton Cell Cortex Cell Projection Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Microtubule Plasma Membrane Coated Pit Focal Adhesion Postsynaptic Density Growth Cone Midbody Endocytic Vesicle Membrane Postsynaptic Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Lipid Binding Identical Protein Binding	GTPase Activity Protein Binding GTP Binding Microtubule Binding SH3 Domain Binding Enzyme Binding
	Biological Process	Endocytosis Cell Communication Signal Transduction Small GTPase Mediated Signal Transduction Actin Cytoskeleton Organization Regulation Of Small GTPase Mediated Signal Transduction	G2/M Transition Of Mitotic Cell Cycle Regulation Of Transcription, DNA-templated Post-Golgi Vesicle-mediated Transport Endocytosis Receptor-mediated Endocytosis Signal Transduction Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Axon Extension Receptor Internalization Transferrin Transport Positive Regulation Of Apoptotic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Nitric Oxide Metabolic Process Synaptic Vesicle Transport Neuron Projection Morphogenesis Regulation Of Nitric-oxide Synthase Activity Membrane Organization Negative Regulation Of Membrane Tubulation
Pathways		Rho GTPase cycle Signaling by Rho GTPases	Retrograde neurotrophin signalling Axon guidance Gap junction degradation Golgi Associated Vesicle Biogenesis L1CAM interactions Recycling pathway of L1 Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Metabolism of nitric oxide Gap junction trafficking and regulation NOSTRIN mediated eNOS trafficking MHC class II antigen presentation eNOS activation and regulation trans-Golgi Network Vesicle Budding Innate Immune System Formation of annular gap junctions Signalling by NGF Gap junction trafficking NGF signalling via TRKA from the plasma membrane Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Adaptive Immune System
Drugs
Diseases
GWAS			Coronary heart disease ( 21347282)
Protein-Protein Interactions		28 interactors: ABL2 AKAP9 ARHGAP12 ARHGAP17 ARHGAP44 CDC42 CREBBP CTNNB1 DNM2 HTT LYN PDE6G POT1 PRKACA RHOJ RHOQ RXRA SH3BP1 SMARCE1 SRC STAT3 TERF1 THRB TINF2 WAS WASF1 WASL WBP11	52 interactors: AMPH AOC1 AP2A1 APP ATF7IP ATXN3 BIN1 CCDC90B CCR5 CCT7 CDK1 CTTN DDX39B DNM1 DYNC1I1 DYNLL1 EIF3L EPS15 FNBP1 FNBP1L GDF9 GRB2 HCK HMGB1 ITSN1 ITSN2 KDR MAN1B1 MANEA MPHOSPH6 MPP6 PDE6G PFN1 PPIB PSTPIP1 PTK2 RPS2 RWDD2B SH3GL2 SH3GLB1 SHANK1 SHANK2 SNX9 SPRY2 SRC TIAM2 TRIP10 TYK2 VAV1 WBP4 ZBTB16 ZFAND6
Entrez ID		9322	1785
HPRD ID		05142	03852
Ensembl ID		ENSG00000125733	ENSG00000079805
Uniprot IDs		Q15642	P50570 Q8N1K8
PDB IDs		2CT4 2EFK 2KE4	2YS1
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Signal Transduction Regulation Of Catalytic Activity Signaling Cell Communication Regulation Of Cellular Component Organization Positive Regulation Of Cellular Metabolic Process Regulation Of Organelle Organization Cellular Response To Stimulus Cellular Component Assembly Organelle Organization Anatomical Structure Morphogenesis Positive Regulation Of Organelle Organization Regulation Of Intracellular Signal Transduction Negative Regulation Of Telomere Maintenance Via Telomerase Response To Stimulus Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cellular Response To Organonitrogen Compound Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Actin Nucleation Regulation Of Signal Transduction Regulation Of Cytoskeleton Organization Regulation Of Cellular Process Negative Regulation Of Telomere Maintenance Negative Regulation Of Biosynthetic Process Homeostatic Process Epithelium Development Innate Immune Response Cellular Response To Hormone Stimulus Regulation Of Telomere Maintenance Via Telomerase Cellular Response To Organic Cyclic Compound Actin Cytoskeleton Organization Cytoskeleton Organization Regulation Of Signaling Cell Development Small GTPase Mediated Signal Transduction Movement Of Cell Or Subcellular Component Response To Organic Cyclic Compound Actin Filament-based Process Phagocytosis Developmental Process Positive Regulation Of Catalytic Activity Anatomical Structure Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Hormone Positive Regulation Of Cellular Biosynthetic Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway	Endocytosis Vesicle-mediated Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Response To Growth Factor Regulation Of ERBB Signaling Pathway Movement Of Cell Or Subcellular Component Locomotion Cellular Response To Organic Substance Chemotaxis Cellular Localization Regulation Of Signal Transduction Regulation Of Signaling Transport Neurotrophin TRK Receptor Signaling Pathway Viral Process Positive Regulation Of Cellular Component Biogenesis Peptidyl-tyrosine Autophosphorylation Neurotrophin Signaling Pathway Regulation Of Apoptotic Process Regulation Of Protein Complex Assembly Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Establishment Of Localization In Cell Regulation Of Cell Death Negative Regulation Of ERBB Signaling Pathway Neuron Projection Morphogenesis Positive Regulation Of Protein Complex Assembly Neuron Projection Development Axon Guidance Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Cellular Component Organization Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Catalytic Activity Response To Organic Substance Nervous System Development Neuron Development Cell Projection Organization Response To External Stimulus Apoptotic Process Cellular Component Assembly Programmed Cell Death Cell Migration Immune System Process Axonogenesis Cell Death
Tagcloud ?		10q21 5q31 5qnca arphpv assembling bipartite c2hc4 c5orf7 d10s1225 dkfzp761f0118 egr2 fbh fch flj14374 fnbp1 informatics jmjc l40411 ncrna overlapped paralogous syndromic tri8h1 tri8h2 trip8 tsga	bcl11b cadherin discovered druggable exhibitedthe fat1 fbxw7 frequencies guide harboured herc1 jak jak3 lymphoblastic mll2 mutational notch1 notch2 phf6 recurrent regulators reln secretase splicing subclonal unfavourable warranted wt1 zrsr2
Tagcloud (Difference) ?		10q21 5q31 5qnca arphpv assembling bipartite c2hc4 c5orf7 d10s1225 dkfzp761f0118 egr2 fbh fch flj14374 fnbp1 informatics jmjc l40411 ncrna overlapped paralogous syndromic tri8h1 tri8h2 trip8 tsga	bcl11b cadherin discovered druggable exhibitedthe fat1 fbxw7 frequencies guide harboured herc1 jak jak3 lymphoblastic mll2 mutational notch1 notch2 phf6 recurrent regulators reln secretase splicing subclonal unfavourable warranted wt1 zrsr2
Tagcloud (Intersection) ?