TRIP10 and ARHGAP12

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		TRIP10	ARHGAP12
Description		thyroid hormone receptor interactor 10	Rho GTPase activating protein 12
Image			No pdb structure
GO Annotations	Cellular Component	Phagocytic Cup Nucleoplasm Cytoplasm Lysosome Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Cell Cortex Membrane Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome	Phagocytic Cup Cytoplasm Plasma Membrane Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Lipid Binding Identical Protein Binding	GTPase Activator Activity Protein Binding
	Biological Process	Endocytosis Cell Communication Signal Transduction Actin Cytoskeleton Organization	Morphogenesis Of An Epithelial Sheet Phagocytosis, Engulfment Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Postsynapse Assembly
Pathways		Clathrin-mediated endocytosis RHOQ GTPase cycle	RAC1 GTPase cycle RHOD GTPase cycle RHOV GTPase cycle RHOF GTPase cycle
Drugs
Diseases
GWAS			C-reactive protein levels ( 24763700) Glycine levels ( 30837465) Intraocular pressure ( 31959993) Pulse pressure ( 27841878 28135244) Systolic blood pressure ( 27841878) Uterine fibroids ( 31649266)
Interacting Genes		43 interacting genes: ABI1 ABL2 AKAP9 ARHGAP12 ARHGAP17 CDC42 CREBBP CTNNB1 DNM2 DTX3 HOXC11 HTT JRK LYN MEOX1 MEOX2 NKX2-5 PAX6 PDE6G POT1 PRKACA RHOJ RHOQ RIN1 RXRA SF3A2 SH3BP1 SHANK3 SMARCE1 SMURF1 SRC STAT3 TERF1 THAP1 THRB TINF2 UTF1 WAS WASF1 WASL WBP11 WWP2 ZBTB7B	5 interacting genes: RAC1 SHANK2 SRPK1 SRPK2 TRIP10
Entrez ID		9322	94134
HPRD ID		05142	06446
Ensembl ID		ENSG00000125733	ENSG00000165322
Uniprot IDs		Q15642 W4VSQ9	Q1RLN5 Q8IWW6
PDB IDs		2CT4 2EFK 2KE4
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Component Organization Actin Filament Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Component Organization Positive Regulation Of Metabolic Process Supramolecular Fiber Organization Positive Regulation Of Macromolecule Metabolic Process Regulation Of Organelle Organization SH3 Domain Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Cell Projection Organization Shelterin Complex Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Signal Transduction Regulation Of Cell Projection Organization Transcription By RNA Polymerase II Actin Filament-based Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Transmembrane Transporter Binding Nuclear Telomere Cap Complex Developmental Process Regulation Of Actin Cytoskeleton Organization Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Telomere Maintenance Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of Primary Metabolic Process Telomere Capping Signal Transduction Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Positive Regulation Of Signal Transduction Establishment Of Organelle Localization Regulation Of Telomere Maintenance Via Telomerase Regulation Of Cytoskeleton Organization Membrane Invagination Ectoderm Development Regulation Of Cell Communication Regulation Of Signaling Cell Projection Morphogenesis Positive Regulation Of DNA Metabolic Process Intracellular Signaling Cassette	Phagocytic Cup Positive Regulation Of Viral Genome Replication Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Interleukin-2 Receptor Complex Defense Response Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Regulation Of Viral Genome Replication Regulation Of Viral Life Cycle Negative Regulation Of Viral Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of T Cell Homeostatic Proliferation Interleukin-2 Binding Interleukin-2 Receptor Activity Rho GDP-dissociation Inhibitor Binding Regulation Of Cell Adhesion Involved In Heart Morphogenesis Regulation Of MRNA Processing Regulation Of Viral Process Nuclear Speck Organization Synaptic Receptor Adaptor Activity Homeostasis Of Number Of Cells Regulation Of Ovarian Follicle Development Cell Cortex Erythrocyte Enucleation Regulation Of RNA Splicing Regulation Of Synaptic Plasticity Auditory Receptor Cell Morphogenesis Engulfment Of Apoptotic Cell Tangential Migration From The Subventricular Zone To The Olfactory Bulb Protein-RNA Complex Assembly Magnesium Ion Binding Positive Regulation Of Cell Population Proliferation Activation-induced Cell Death Of T Cells Kinocilium G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Postsynaptic Membrane Hepatocyte Growth Factor Receptor Signaling Pathway Activated T Cell Proliferation Regulation Of Neuron Maturation Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering R-loop Processing Positive Regulation Of Bicellular Tight Junction Assembly Regulation Of Interleukin-23 Production
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