TRIP12 and PARP1

Number of citations of the paper that reports this interaction (PubMedID 32755579)
58

Data Source:
BioGRID (enzymatic study, proximity labelling technology)

		TRIP12	PARP1
Description		thyroid hormone receptor interactor 12	poly(ADP-ribose) polymerase 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Speck	Chromosome, Telomeric Region Chromatin Nucleus Nuclear Envelope Nucleoplasm Transcription Regulator Complex Chromosome Nucleolus Cytoplasm Mitochondrion Cytosol Membrane Nuclear Body Protein-containing Complex Protein-DNA Complex Site Of Double-strand Break Nuclear Replication Fork Site Of DNA Damage
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Nuclear Thyroid Hormone Receptor Binding Ubiquitin Protein Ligase Activity	DNA Binding Chromatin Binding Damaged DNA Binding RNA Binding Catalytic Activity NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Enzyme Activator Activity Zinc Ion Binding Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Enzyme Binding Protein Kinase Binding Nuclear Estrogen Receptor Binding Nucleosome Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Metal Ion Binding NAD Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding R-SMAD Binding NAD DNA ADP-ribosyltransferase Activity Transcription Regulator Activator Activity NAD+-protein-serine ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Ubiquitination Heterochromatin Boundary Formation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Embryonic Development DNA Repair-dependent Chromatin Remodeling	Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Immune System Process DNA Repair Double-strand Break Repair Transcription By RNA Polymerase II Apoptotic Process DNA Damage Response Mitochondrion Organization Transforming Growth Factor Beta Receptor Signaling Pathway Response To Gamma Radiation Positive Regulation Of Cardiac Muscle Hypertrophy Carbohydrate Biosynthetic Process Protein Autoprocessing Signal Transduction Involved In Regulation Of Gene Expression Macrophage Differentiation DNA ADP-ribosylation Mitochondrial DNA Metabolic Process Positive Regulation Of DNA-templated Transcription, Elongation Cellular Response To Insulin Stimulus Regulation Of Protein Localization Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Transcription Elongation By RNA Polymerase II Cellular Response To Oxidative Stress Cellular Response To UV Protein Modification Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Mitochondrial DNA Repair Innate Immune Response Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Innate Immune Response Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Decidualization Positive Regulation Of Mitochondrial Depolarization Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Necroptotic Process Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Protein Localization To Chromatin Cellular Response To Zinc Ion Cellular Response To Transforming Growth Factor Beta Stimulus Replication Fork Reversal DNA Repair-dependent Chromatin Remodeling Negative Regulation Of CGAS/STING Signaling Pathway Transcription Pausing By RNA Polymerase II Positive Regulation Of Protein Localization To Nucleus Cellular Response To Oxygen-containing Compound Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Response To Aldosterone Negative Regulation Of Adipose Tissue Development Positive Regulation Of Adipose Tissue Development Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Cellular Response To Amyloid-beta Positive Regulation Of Myofibroblast Differentiation Regulation Of Base-excision Repair Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Cellular Response To Nerve Growth Factor Stimulus Protein Localization To Site Of Double-strand Break ATP Generation From Poly-ADP-D-ribose Negative Regulation Of ATP Biosynthetic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	POLB-Dependent Long Patch Base Excision Repair vRNA Synthesis Downregulation of SMAD2/3:SMAD4 transcriptional activity SUMOylation of DNA damage response and repair proteins HDR through MMEJ (alt-NHEJ) DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER
Drugs			Theophylline Zinc Carba-nicotinamide-adenine-dinucleotide NU1025 Nicotinamide 2-{3-[4-(4-Fluorophenyl)-3,6-Dihydro-1(2h)-Pyridinyl]Propyl}-8-Methyl-4(3h)-Quinazolinone 3-Methoxybenzamide 2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide 3,4-Dihydro-5-Methyl-Isoquinolinone 2-(3'-Methoxyphenyl) Benzimidazole-4-Carboxamide 6-AMINO-BENZO[DE]ISOQUINOLINE-1,3-DIONE Veliparib A-620223 5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONE Olaparib Talazoparib Niraparib Rucaparib Iniparib Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Carotid intima media thickness x smoking interaction ( 32117412) Estimated glomerular filtration rate ( 31015462 31152163) Metabolite levels ( 23823483) Systolic blood pressure ( 30224653) Weight ( 28552196)	Coronary artery disease ( 29212778) Leukocyte telomere length ( 31171785 32109421) Melanoma ( 21983785) Mild to moderate chronic kidney disease ( 31178898) Nevus count or cutaneous melanoma ( 30429480 32341527) Platelet count ( 29403010) Telomere length ( 29151059)
Interacting Genes		31 interacting genes: ATF7IP CARNS1 CDKN2A CELSR3 CLSTN1 CUL2 DSCR9 ERG FBXW7 GBA1 LCOR MTNR1A MTNR1B MYC NAE1 NMI NRIP1 OGT PARP1 PTF1A SMAD4 SMAD9 SOX6 SRPK2 TAF10 THRB UBC UBE2D1 UBE2D2 UBE2L3 UBE4B	123 interacting genes: AATF ANXA1 APTX ATM ATR BCL2 BGLT3 BLID BRD7 BUB3 CASP1 CASP3 CASP7 CASP8 CD86 CDKN1A CEBPA CENPA CENPB CTCF CTSB CTSG DTX2 DUX4 E2F1 E4F1 EPB41L2 ERBB2 ERCC6 ERG ETS1 FNDC3B FOXO1 GTF2F1 GZMB GZMM H1-1 H1-2 H1-5 H2AC18 H2BC4 H3-4 H4C3 HDAC1 HDAC3 HECTD3 HIPK2 HMGN1 HMGN2 HMGN4 HOXB7 HPF1 HSPA2 IKBKG IL24 KAT2B KLF5 LIG3 LINC00624 LZTR1 MACROH2A1 MALAT1 MED14 MED6 MORC2 MTA3 MYBL2 NAT10 NCL NCOA6 NEDD8 NFATC1 NFKB1 NPM1 NRF1 NUDT16 OGT OVOL2 PARP2 PARP3 PCNA PIAS4 POLA1 POLA2 POU2F1 PRKDC RARA RASL10B RBM14 RELA RNF10 RNF144A RNF168 RNF4 RPS3A RSPH1 RXRA SENP1 SENP3 SMURF2 SP1 SREK1 SUMO2 SUPT16H SWAP70 TCF3 TCF4 THRSP TP53 TP53BP1 TRIP12 UBE2I USP1 USP15 USP7 WEE2-AS1 WRN XRCC1 XRCC5 XRCC6 ZBTB16 ZBTB9 ZNF423
Entrez ID		9320	142
HPRD ID		05144	01435
Ensembl ID		ENSG00000153827	ENSG00000143799
Uniprot IDs		A0A6Q8PGG9 A0A6Q8PHK0 A0A994J4J0 A0A994J569 A0A994J755 H7C1L9 Q14669	P09874
PDB IDs		9BKR 9BKS	1UK0 1UK1 1WOK 2COK 2CR9 2CS2 2DMJ 2JVN 2L30 2L31 2N8A 2RCW 2RD6 2RIQ 3GJW 3GN7 3L3L 3L3M 3OD8 3ODA 3ODC 3ODE 4AV1 4DQY 4GV7 4HHY 4HHZ 4L6S 4OPX 4OQA 4OQB 4PJT 4R5W 4R6E 4RV6 4UND 4UXB 4XHU 4ZZZ 5A00 5DS3 5HA9 5KPN 5KPO 5KPP 5KPQ 5WRQ 5WRY 5WRZ 5WS0 5WS1 5WTC 5XSR 5XST 5XSU 6BHV 6GHK 6M3I 6NRF 6NRG 6NRH 6NRI 6NRJ 6NTU 6VKK 6VKO 6VKQ 6XVW 7AAA 7AAB 7AAC 7AAD 7CMW 7KK2 7KK3 7KK4 7KK5 7KK6 7ONR 7ONS 7ONT 7S68 7S6H 7S6M 7S81 7SCY 7SCZ 8FYY 8FYZ 8FZ1 8G0H 8HE7 8HLR 8JNZ 8U4W 9BPY 9CKC 9DMC 9ETQ 9ETR
Enriched GO Terms of Interacting Partners?		Protein Modification Process Positive Regulation Of Macromolecule Metabolic Process Nuclear Estrogen Receptor Binding Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Ubiquitin Protein Ligase Binding Post-translational Protein Modification Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein Modification By Small Protein Conjugation Protein Ubiquitination Modification-dependent Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Proteolysis Positive Regulation Of Post-translational Protein Modification Regulation Of Post-translational Protein Modification Regulation Of Neuron Apoptotic Process Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Protein-containing Complex Ubiquitin-dependent Protein Catabolic Process Nucleus Negative Regulation Of DNA-templated Transcription DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Polyubiquitination Cell Cycle Phase Transition Positive Regulation Of Macromolecule Biosynthetic Process Protein Metabolic Process Chromatin Regulation Of Nucleobase-containing Compound Metabolic Process Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Melatonin Receptor Activity Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Macromolecule Metabolic Process	Nucleoplasm Nucleus DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Chromatin Organization Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Damage Response Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Chromatin Remodeling Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Metabolic Process Macromolecule Metabolic Process Chromosome Protein Modification Process Negative Regulation Of DNA Metabolic Process DNA Repair DNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Chromatin Cellular Response To Stress Post-translational Protein Modification Negative Regulation Of Biosynthetic Process Transcription Cis-regulatory Region Binding Regulation Of DNA Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Double-strand Break Repair Negative Regulation Of Cell Cycle Protein Localization To Chromosome Negative Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Process Transcription Regulator Complex
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