TRIP12 and UBE4B

Number of citations of the paper that reports this interaction (PubMedID 18627766)
0

Data Source:
BioGRID (pull down)

		TRIP12	UBE4B
Description		thyroid hormone receptor interactor 12	ubiquitination factor E4B
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Speck	Ubiquitin Ligase Complex Nucleus Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Nuclear Thyroid Hormone Receptor Binding Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Enzyme Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Ubiquitination Heterochromatin Boundary Formation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Embryonic Development DNA Repair-dependent Chromatin Remodeling	Protein Polyubiquitination Ventricular Trabecula Myocardium Morphogenesis Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Granzyme-mediated Apoptotic Signaling Pathway Response To UV Protein Ubiquitination Protein Catabolic Process Neuron Projection Development Response To Endoplasmic Reticulum Stress ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Carotid intima media thickness x smoking interaction ( 32117412) Estimated glomerular filtration rate ( 31015462 31152163) Metabolite levels ( 23823483) Systolic blood pressure ( 30224653) Weight ( 28552196)	Atrial fibrillation ( 29892015) Femur bone mineral density x serum urate levels interaction ( 34046847) Hemoglobin levels ( 33491795) Hepatocellular carcinoma ( 20676096) Hip circumference adjusted for BMI ( 34021172) Resting heart rate ( 27798624)
Interacting Genes		31 interacting genes: ATF7IP CARNS1 CDKN2A CELSR3 CLSTN1 CUL2 DSCR9 ERG FBXW7 GBA1 LCOR MTNR1A MTNR1B MYC NAE1 NMI NRIP1 OGT PARP1 PTF1A SMAD4 SMAD9 SOX6 SRPK2 TAF10 THRB UBC UBE2D1 UBE2D2 UBE2L3 UBE4B	27 interacting genes: ATXN3 CASP3 CASP6 CASP7 CDKN2A CNTN2 DNAJC7 ESR1 FEZ1 GZMB HGS HRAS MAPK3 OTUB1 PGAM5 PPP3CA PRMT1 PYCR2 RAD23A RIPK4 TP53 TRA2A TRIP12 UBE2D2 UBE2D3 VAV2 VCP
Entrez ID		9320	10277
HPRD ID		05144	11659
Ensembl ID		ENSG00000153827	ENSG00000130939
Uniprot IDs		A0A6Q8PGG9 A0A6Q8PHK0 A0A994J4J0 A0A994J569 A0A994J755 H7C1L9 Q14669	O95155
PDB IDs		9BKR 9BKS	2KRE 3L1X 3L1Z 5O75
Enriched GO Terms of Interacting Partners?		Protein Modification Process Positive Regulation Of Macromolecule Metabolic Process Nuclear Estrogen Receptor Binding Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Ubiquitin Protein Ligase Binding Post-translational Protein Modification Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein Modification By Small Protein Conjugation Protein Ubiquitination Modification-dependent Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Proteolysis Positive Regulation Of Post-translational Protein Modification Regulation Of Post-translational Protein Modification Regulation Of Neuron Apoptotic Process Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Protein-containing Complex Ubiquitin-dependent Protein Catabolic Process Nucleus Negative Regulation Of DNA-templated Transcription DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Polyubiquitination Cell Cycle Phase Transition Positive Regulation Of Macromolecule Biosynthetic Process Protein Metabolic Process Chromatin Regulation Of Nucleobase-containing Compound Metabolic Process Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Melatonin Receptor Activity Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Macromolecule Metabolic Process	Catabolic Process Cytosol Cellular Response To Staurosporine Proteolysis DNA Damage Response Protein Metabolic Process Macromolecule Catabolic Process Protein Catabolic Process Protein Modification Process Nucleoplasm Response To Stress Pyroptotic Inflammatory Response Positive Regulation Of Intracellular Signal Transduction Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Metabolic Process Programmed Cell Death DNA Repair Cell Death Intracellular Signal Transduction Regulation Of Protein Metabolic Process Cysteine-type Peptidase Activity Regulation Of Proteolysis Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Macromolecule Metabolic Process Regulation Of Metabolic Process Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Regulation Of Primary Metabolic Process TORC1 Signaling Negative Regulation Of TORC1 Signaling Post-translational Protein Modification Positive Regulation Of Neuron Apoptotic Process Nucleic Acid Metabolic Process Macroautophagy Apoptotic Process Autophagy Regulation Of Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling TOR Signaling Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of TOR Signaling DNA Metabolic Process Regulation Of Signal Transduction Regulation Of Cellular Response To Stress Regulation Of TORC1 Signaling Regulation Of Macromolecule Metabolic Process
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