TRIP12 and UBE4B

Number of citations of the paper that reports this interaction (PMID 18627766)
8

Data Source:
BioGRID (pull down)

		TRIP12	UBE4B
Gene Name		thyroid hormone receptor interactor 12	ubiquitination factor E4B
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Ubiquitin Ligase Complex Nucleus Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity Thyroid Hormone Receptor Binding	Ligase Activity Enzyme Binding Ubiquitin-ubiquitin Ligase Activity
	Biological Process	DNA Repair Cellular Response To DNA Damage Stimulus Embryo Development Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Histone H2A K63-linked Ubiquitination Negative Regulation Of Double-strand Break Repair	Granzyme-mediated Apoptotic Signaling Pathway Response To UV Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Hepatocellular carcinoma ( 20676096)
Protein-Protein Interactions		14 interactors: ATF7IP CARNS1 CDKN2A CELSR3 CLSTN1 NAE1 NMI PTF1A SMAD9 SOX6 THRB UBE2D1 UBE2L3 UBE4B	15 interactors: ATXN3 CASP3 CASP6 CASP7 CDKN2A DNAJC7 FEZ1 GZMB HGS TP53 TRIP12 UBE2D2 UBE2D3 VAV2 VCP
Entrez ID		9320	10277
HPRD ID		05144	11659
Ensembl ID		ENSG00000153827	ENSG00000130939
Uniprot IDs		Q14669	O95155
PDB IDs			2KRE 3L1X 3L1Z
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Regulation Of Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Response To Stimulus Positive Regulation Of Macromolecule Biosynthetic Process Protein Polyubiquitination Positive Regulation Of Gene Expression Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Cellular Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Response To Transforming Growth Factor Beta Regulation Of RNA Biosynthetic Process Regulation Of Protein Ubiquitination Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Mitotic Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process Protein Ubiquitination Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Cell Cycle Phase Transition Negative Regulation Of RNA Biosynthetic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Carnosine Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Biosynthetic Process Signal Transduction Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Ubiquitin-protein Transferase Activity Response To Stimulus Positive Regulation Of Ligase Activity BMP Signaling Pathway Regulation Of Transcription, DNA-templated	Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Processing Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Cellular Response To Stress Positive Regulation Of Endopeptidase Activity Apoptotic Signaling Pathway Positive Regulation Of Peptidase Activity Cellular Response To Stimulus Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Aging Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Glial Cell Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Cellular Response To DNA Damage Stimulus Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cellular Macromolecule Catabolic Process Regulation Of Apoptotic DNA Fragmentation Ubiquitin-dependent Protein Catabolic Process Apoptotic Mitochondrial Changes Modification-dependent Protein Catabolic Process Regulation Of Apoptotic Process Execution Phase Of Apoptosis Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Regulation Of Cell Death Cellular Response To Growth Factor Stimulus Negative Regulation Of Macroautophagy Protein Ubiquitination DNA Repair Response To Growth Factor Protein Modification By Small Protein Conjugation DNA Metabolic Process Protein Catabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Positive Regulation Of Proteolysis Response To Abiotic Stimulus Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels
Tagcloud ?		aberrant alternative aml another arf catabolic cd8 clean confidential degs differentially donors events exon3 gb integrated investigations isoform ligase macromolecule mononuclear pairs profiling remission sequencing skipping splicing suppresses validated	aberrantly amplified archived battery bel caspase3 cleaved colony contradictory hcc hep1 hep3b hepatocellular hepatocyte hepg2 huh7 immunohistochjemical inc lo2 oncogene periodicals resection sk smmc speculated ubiquitination undergone wiley
Tagcloud (Difference) ?		aberrant alternative aml another arf catabolic cd8 clean confidential degs differentially donors events exon3 gb integrated investigations isoform ligase macromolecule mononuclear pairs profiling remission sequencing skipping splicing suppresses validated	aberrantly amplified archived battery bel caspase3 cleaved colony contradictory hcc hep1 hep3b hepatocellular hepatocyte hepg2 huh7 immunohistochjemical inc lo2 oncogene periodicals resection sk smmc speculated ubiquitination undergone wiley
Tagcloud (Intersection) ?