TRIP12 and ATF7IP

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
HPRD (two hybrid)

		TRIP12	ATF7IP
Description		thyroid hormone receptor interactor 12	activating transcription factor 7 interacting protein
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Speck	Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Nuclear Body
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Nuclear Thyroid Hormone Receptor Binding Ubiquitin Protein Ligase Activity	Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding ATP Hydrolysis Activity
	Biological Process	Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Ubiquitination Heterochromatin Boundary Formation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Embryonic Development DNA Repair-dependent Chromatin Remodeling	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation-dependent Constitutive Heterochromatin Formation Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	PKMTs methylate histone lysines Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Drugs
Diseases
GWAS		Carotid intima media thickness x smoking interaction ( 32117412) Estimated glomerular filtration rate ( 31015462 31152163) Metabolite levels ( 23823483) Systolic blood pressure ( 30224653) Weight ( 28552196)	Breast cancer ( 24143190) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Height ( 31562340 33713608) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Leukocyte telomere length ( 32109421) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Prostate-specific antigen levels ( 23359319) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 23666240 28604728 28604732)
Interacting Genes		31 interacting genes: ATF7IP CARNS1 CDKN2A CELSR3 CLSTN1 CUL2 DSCR9 ERG FBXW7 GBA1 LCOR MTNR1A MTNR1B MYC NAE1 NMI NRIP1 OGT PARP1 PTF1A SMAD4 SMAD9 SOX6 SRPK2 TAF10 THRB UBC UBE2D1 UBE2D2 UBE2L3 UBE4B	71 interacting genes: A2M ACTB ACTG1 AP1B1 CADM1 CEP250 COL4A2 CREB1 CREBBP CSPG4 DISC1 DMTF1 DNM2 EHMT2 EPG5 FLNB FLT4 GMEB1 GTF2E2 GTF2F1 GTF2H1 HEYL HLA-B HMGB1 HSPG2 KIF13A KRT7 LAMA4 LAMA5 LAMC1 LUC7L2 MACF1 MBD1 MCAM MED4 MRI1 NOMO1 NPR1 PAPPA PAPPA2 PCDH1 PEX6 PIAS3 PKD1 PLEKHB2 POLR2C POLR2D POLR2G PRSS8 PSG3 QRICH1 RPS3A RRBP1 SENP3 SETDB1 SLC12A4 SMAD4 SP1 SPTBN1 SREBF2 STBD1 STRN SUMO2 SUSD1 SVEP1 TRIP12 TTC3 UBE2I ZBTB6 ZNF350 ZNF518A
Entrez ID		9320	55729
HPRD ID		05144	09811
Ensembl ID		ENSG00000153827	ENSG00000171681
Uniprot IDs		A0A6Q8PGG9 A0A6Q8PHK0 A0A994J4J0 A0A994J569 A0A994J755 H7C1L9 Q14669	B3KNI7 B3KQF8 Q6VMQ6
PDB IDs		9BKR 9BKS	2RPQ
Enriched GO Terms of Interacting Partners?		Protein Modification Process Positive Regulation Of Macromolecule Metabolic Process Nuclear Estrogen Receptor Binding Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Ubiquitin Protein Ligase Binding Post-translational Protein Modification Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein Modification By Small Protein Conjugation Protein Ubiquitination Modification-dependent Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Proteolysis Positive Regulation Of Post-translational Protein Modification Regulation Of Post-translational Protein Modification Regulation Of Neuron Apoptotic Process Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Protein-containing Complex Ubiquitin-dependent Protein Catabolic Process Nucleus Negative Regulation Of DNA-templated Transcription DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Polyubiquitination Cell Cycle Phase Transition Positive Regulation Of Macromolecule Biosynthetic Process Protein Metabolic Process Chromatin Regulation Of Nucleobase-containing Compound Metabolic Process Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Melatonin Receptor Activity Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Macromolecule Metabolic Process	Transcription By RNA Polymerase II DNA-templated Transcription Morphogenesis Of A Polarized Epithelium Transcription Initiation At RNA Polymerase II Promoter Nucleoplasm DNA-templated Transcription Initiation Basement Membrane Laminin-11 Complex Laminin-10 Complex Lymph Vessel Morphogenesis RNA Polymerase II, Core Complex Nucleobase-containing Compound Biosynthetic Process SUMO Transferase Activity Regulation Of Transepithelial Transport Dense Body Regulation Of Multicellular Organismal Development Nuclear Thyroid Hormone Receptor Binding Presynaptic Cytosol Macromolecule Biosynthetic Process Postsynaptic Cytosol Structural Constituent Of Postsynaptic Actin Cytoskeleton Maintenance Of Blood-brain Barrier Proximal Tubule Development Focal Adhesion DNA-directed RNA Polymerase Complex Golgi To Plasma Membrane Protein Transport Histone H3K9me2 Methyltransferase Activity DNA Methylation-dependent Constitutive Heterochromatin Formation Extracellular Exosome Positive Regulation Of Endothelial Cell Proliferation Regulation Of Transcription By RNA Polymerase II Histone H3K9 Methyltransferase Activity Nucleus
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