ACVRL1

Name	activin A receptor like type 1
Structure
Novel Interactors	1 novel interactors: SH2D4A
Interactors	15 interactors: ACVR2A BAMBI CSNK2B EIF4E FKBP1A GDF2 RNF31 SMAD1 SNX6 TGFB1 TGFB3 TGFBR1 TGFBR2 TGFBRAP1 XIAP
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane BMP Receptor Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Kinase Activity Activin Receptor Activity, Type I Transferase Activity Protein Kinase Binding SMAD Binding Metal Ion Binding Activin Binding Transforming Growth Factor Beta Binding BMP Receptor Activity
	Biological Process	Angiogenesis In Utero Embryonic Development Regulation Of Endothelial Cell Proliferation Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Lymphangiogenesis Blood Vessel Maturation Blood Vessel Remodeling Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Endocardial Cushion Morphogenesis Regulation Of DNA Replication Regulation Of DNA-templated Transcription Negative Regulation Of Cell Adhesion Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Heart Development Blood Circulation Regulation Of Blood Pressure Negative Regulation Of Cell Population Proliferation Dorsal/ventral Pattern Formation Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Gene Expression Cell Differentiation Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Epithelial Cell Differentiation Positive Regulation Of Chondrocyte Differentiation Activin Receptor Signaling Pathway Wound Healing, Spreading Of Epidermal Cells Dorsal Aorta Morphogenesis Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Endothelial Cell Differentiation Positive Regulation Of Cell Differentiation Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Blood Vessel Morphogenesis Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of SMAD Protein Signal Transduction Epithelial Tube Morphogenesis Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Endothelial Tube Morphogenesis Retina Vasculature Development In Camera-type Eye Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To BMP Stimulus Circulatory System Development Endocardial Cushion To Mesenchymal Transition Positive Regulation Of Bicellular Tight Junction Assembly Regulation Of Multicellular Organismal Development
Pathways	Signaling by BMP
Drugs	ATP
Diseases	Hereditary hemorrhagic telangiectasia (HHT)
GWAS	Appendicular lean mass ( 33097823 ) Hematocrit ( 29403010 ) Hemoglobin ( 32888494 29403010 ) Hemoglobin levels ( 32327693 ) Lymphocyte count ( 32888494 ) Medication use (HMG CoA reductase inhibitors) ( 31015401 ) Monocyte count ( 32888494 27863252 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 32888494 ) Platelet count ( 32888494 ) Plateletcrit ( 27863252 32888494 ) Urate levels ( 23263486 ) White blood cell count ( 27863252 32888494 )
Entrez ID	94
HPRD ID	03181
Ensembl ID	ENSG00000139567
Uniprot IDs	A0A0S2Z2Y4 A0A0S2Z310 H3BTZ2 P37023
PDB IDs	2LCR 3MY0 4FAO 6SF1 6SF2 6SF3 7PPC
GO Terms Enriched among Interactors ?	Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of SMAD Protein Signal Transduction Type I Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cellular Response To Growth Factor Stimulus Type II Transforming Growth Factor Beta Receptor Binding Response To Growth Factor Transforming Growth Factor Beta Receptor Binding Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Type III Transforming Growth Factor Beta Receptor Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Activin Receptor Signaling Pathway Activin Receptor Complex Activin Receptor Activity, Type I Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Epithelial To Mesenchymal Transition Activin Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Differentiation I-SMAD Binding Positive Regulation Of Vasculature Development Regulation Of Cartilage Development Regulation Of Signal Transduction Transforming Growth Factor Beta Binding Tissue Morphogenesis Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Anatomical Structure Morphogenesis Response To Cholesterol Regulation Of Activin Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Gland Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex Regulation Of Cell Differentiation Signal Transduction Animal Organ Morphogenesis Positive Regulation Of Multicellular Organismal Process Langerhans Cell Differentiation