ACVRL1

Gene Name		activin A receptor type II-like 1
Image
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane Cell Surface Dendrite Neuronal Cell Body
	Molecular Function	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Activin Receptor Activity, Type I Protein Kinase Binding SMAD Binding Metal Ion Binding Activin Binding Transforming Growth Factor Beta Binding
	Biological Process	Angiogenesis In Utero Embryonic Development Regulation Of Endothelial Cell Proliferation Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Lymphangiogenesis Blood Vessel Maturation Blood Vessel Remodeling Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of DNA Replication Regulation Of Transcription, DNA-templated Protein Phosphorylation Negative Regulation Of Cell Adhesion Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Blood Circulation Regulation Of Blood Pressure Negative Regulation Of Cell Proliferation Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Signal Transduction By Phosphorylation Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Activin Receptor Signaling Pathway Wound Healing, Spreading Of Epidermal Cells Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Heterooligomerization Negative Regulation Of Focal Adhesion Assembly Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Endothelial Tube Morphogenesis Retina Vasculature Development In Camera-type Eye Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To BMP Stimulus Negative Regulation Of DNA Biosynthetic Process
Pathways
Drugs		Adenosine triphosphate
Diseases
GWAS		Urate levels ( 23263486)
Protein-protein Interactions		12 interactors: ACVR2A BAMBI CSNK2B FKBP1A SMAD1 SNX6 TGFB1 TGFB3 TGFBR1 TGFBR2 TGFBRAP1 XIAP
Entrez ID		94
HPRD ID		03181
Ensembl ID		ENSG00000139567
Uniprot IDs		E7EN07 P37023
PDB IDs		2LCR 3MY0 4FAO
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Positive Regulation Of Protein Modification Process Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Regulation Of Epithelial To Mesenchymal Transition SMAD Protein Complex Assembly Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Pathway-restricted SMAD Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of SMAD Protein Import Into Nucleus Regulation Of SMAD Protein Import Into Nucleus Regulation Of Signaling Regulation Of Protein Metabolic Process Regulation Of Cell Proliferation Regulation Of Phosphorus Metabolic Process Regulation Of Binding Positive Regulation Of Ossification Positive Regulation Of Protein Import Into Nucleus Skeletal System Development Response To Cholesterol Signal Transduction By Phosphorylation Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Protein Phosphorylation Signal Transduction
Tagcloud ?		a1cf activins ancestry atxn2 b3gnt4 baz1b consortium excretion fractional gout gugc hlf hnf4g implicate inhbb inhibins maf nfat5 painful prkag2 replicated sfmbt1 stc1 tmem171 trim46 ube2q2 urate vegfa