ACVRL1 and CSNK2B

Number of citations of the paper that reports this interaction (PubMedID 19592636)
52

Data Source:
BioGRID (pull down)

		ACVRL1	CSNK2B
Description		activin A receptor like type 1	casein kinase 2 beta
Image
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane BMP Receptor Complex	Chromatin Fibrillar Center Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Protein Kinase CK2 Complex PML Body PcG Protein Complex Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Kinase Activity Activin Receptor Activity, Type I Transferase Activity Protein Kinase Binding SMAD Binding Metal Ion Binding Activin Binding Transforming Growth Factor Beta Binding BMP Receptor Activity	Chromatin Binding Protein Serine/threonine Kinase Activity Signaling Receptor Binding Protein Binding Protein Kinase Regulator Activity Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Angiogenesis In Utero Embryonic Development Regulation Of Endothelial Cell Proliferation Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Lymphangiogenesis Blood Vessel Maturation Blood Vessel Remodeling Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Endocardial Cushion Morphogenesis Regulation Of DNA Replication Regulation Of DNA-templated Transcription Negative Regulation Of Cell Adhesion Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Heart Development Blood Circulation Regulation Of Blood Pressure Negative Regulation Of Cell Population Proliferation Dorsal/ventral Pattern Formation Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Gene Expression Cell Differentiation Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Epithelial Cell Differentiation Positive Regulation Of Chondrocyte Differentiation Activin Receptor Signaling Pathway Wound Healing, Spreading Of Epidermal Cells Dorsal Aorta Morphogenesis Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Endothelial Cell Differentiation Positive Regulation Of Cell Differentiation Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Blood Vessel Morphogenesis Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of SMAD Protein Signal Transduction Epithelial Tube Morphogenesis Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Endothelial Tube Morphogenesis Retina Vasculature Development In Camera-type Eye Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To BMP Stimulus Circulatory System Development Endocardial Cushion To Mesenchymal Transition Positive Regulation Of Bicellular Tight Junction Assembly Regulation Of Multicellular Organismal Development	Signal Transduction Negative Regulation Of Cell Population Proliferation Wnt Signaling Pathway Peptidyl-threonine Phosphorylation Release From Viral Latency Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Activin Receptor Signaling Pathway Adiponectin-activated Signaling Pathway Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of SMAD Protein Signal Transduction Endothelial Tube Morphogenesis Protein-containing Complex Assembly Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Viral Life Cycle
Pathways		Signaling by BMP	Synthesis of PC WNT mediated activation of DVL Condensation of Prometaphase Chromosomes Signal transduction by L1 Neutrophil degranulation Regulation of TP53 Activity through Phosphorylation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Receptor Mediated Mitophagy RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN stability and activity KEAP1-NFE2L2 pathway Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Maturation of hRSV A proteins SPOP-mediated proteasomal degradation of PD-L1(CD274) Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
Drugs		ATP	ATP Quercetin
Diseases		Hereditary hemorrhagic telangiectasia (HHT)
GWAS		Appendicular lean mass ( 33097823) Hematocrit ( 29403010) Hemoglobin ( 32888494 29403010) Hemoglobin levels ( 32327693) Lymphocyte count ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Monocyte count ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 27863252 32888494) Urate levels ( 23263486) White blood cell count ( 27863252 32888494)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Cutaneous lupus erythematosus ( 25827949) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Systemic lupus erythematosus ( 26316170) Ulcerative colitis ( 28067908)
Interacting Genes		15 interacting genes: ACVR2A BAMBI CSNK2B EIF4E FKBP1A GDF2 RNF31 SMAD1 SNX6 TGFB1 TGFB3 TGFBR1 TGFBR2 TGFBRAP1 XIAP	222 interacting genes: ABHD4 ACTB ACTL6B ACTR1B ACTR5 ACVRL1 ADD1 ADH5 ANGPT2 ANKRD28 AP2M1 APLP1 ARAF ATF1 ATG101 ATXN3 BAG6 BANP BCCIP BHLHE41 BID BMI1 BRCA1 BTF3 C6orf136 CACNA1A CALM1 CCDC187 CCNB1 CCNH CD163 CD81 CDC25B CDC34 CDK1 CDK20 CDKN1A CHEK1 CHRNA4 CIC CIPC CLOCK COIL COL4A2 COPS3 COPS7A CPNE7 CREB1 CSN1S1 CSN2 CSNK1E CSNK2A1 CSNK2A2 CST1 CTDP1 CTNNB1 DACT1 DALRD3 DAXX DELEC1 DENND5A DNMT1 DPF3 DSCAM DUX1 DYNLT2B EIF2S2 EIF5 EIF6 EPS8 ERCC6 ERCC8 ESR1 FAF1 FAM86C1P FBXL15 FBXL5 FGB FGF1 FGF2 FIBP FKBP3 FTH1 FXR1 FXR2 GADD45GIP1 GAMT GBP2 GLB1 GLIS2 GNB5 GRIN2A GRIN2B GRK2 GSK3B HEXB HNRNPA2B1 HOXB5 HOXB6 HTRA1 HYPK IER3IP1 INO80B INTS11 IRS1 ITSN1 KDM6B KIF2C LCK LEPR LMO4 LRP5L LTB4R2 LYN LYST MAPK14 MBD4 MDM2 MME MOXD1 MPP2 NAP1L1 NCF1 NGDN NMT2 NOLC1 NOTCH3 NPAS2 NRBP1 NRF1 NTAQ1 ODC1 OGA OGT PDS5A PER1 PER2 PFKFB4 PHF11 PIMREG PIN1 PITPNA PLXNA3 POT1 PPID PPP1CA PPP1CB PPP1CC PPP2CA PPP2R1A PPP2R1B PPP2R5D PPP2R5E PPP3CC PRKAB2 PRKCZ PRNP PROC PTPRK PTTG2 PYROXD2 RAD17 RAD51 RFC1 RNF126 RNF7 RORB RPA1 RPL13 RPL41 RPL5 RPS6KB1 RRAD RXRA SARNP SDHA SEC11A SELENOI SHMT1 SHMT2 SIMC1 SNX2 SPOUT1 SPSB3 SSB STAT5A STAU1 STK16 SUMO2 SYNE4 TCEAL7 TENM1 TFAP2A TFAP2D TLE1 TLX3 TNFAIP1 TOP2B TP53 TP53BP2 TP63 TRIM54 TSEN54 TUBB2B TWF1 UBE2I UPF1 USO1 UTP14A VDAC1 VMA22 VRK3 WDR1 WDR18 WFIKKN1 WWOX ZNF19 ZNF410 ZNF44 ZNF71 ZNF784 ZNHIT1
Entrez ID		94	1460
HPRD ID		03181	00278
Ensembl ID		ENSG00000139567	ENSG00000204435
Uniprot IDs		A0A0S2Z2Y4 A0A0S2Z310 H3BTZ2 P37023	A0A1U9X7J2 N0E4C7 P67870
PDB IDs		2LCR 3MY0 4FAO 6SF1 6SF2 6SF3 7PPC	1DS5 1JWH 1QF8 3EED 4DGL 4MD7 4MD8 4MD9 4NH1 6Q38
Enriched GO Terms of Interacting Partners?		Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of SMAD Protein Signal Transduction Type I Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cellular Response To Growth Factor Stimulus Type II Transforming Growth Factor Beta Receptor Binding Response To Growth Factor Transforming Growth Factor Beta Receptor Binding Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Type III Transforming Growth Factor Beta Receptor Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Activin Receptor Signaling Pathway Activin Receptor Complex Activin Receptor Activity, Type I Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Epithelial To Mesenchymal Transition Activin Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Differentiation I-SMAD Binding Positive Regulation Of Vasculature Development Regulation Of Cartilage Development Regulation Of Signal Transduction Transforming Growth Factor Beta Binding Tissue Morphogenesis Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Anatomical Structure Morphogenesis Response To Cholesterol Regulation Of Activin Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Gland Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex Regulation Of Cell Differentiation Signal Transduction Animal Organ Morphogenesis Positive Regulation Of Multicellular Organismal Process Langerhans Cell Differentiation	Nucleus Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Cytosol Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of DNA Metabolic Process Protein Binding Regulation Of Cell Cycle Cytoplasm Macromolecule Metabolic Process Positive Regulation Of DNA Metabolic Process DNA Damage Response Rhythmic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Circadian Rhythm Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Gene Expression Chromosome Organization Regulation Of Transcription By RNA Polymerase II Response To Light Stimulus Regulation Of Cell Cycle Process Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Circadian Regulation Of Gene Expression Nucleic Acid Metabolic Process Circadian Rhythm Positive Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Programmed Cell Death Photoperiodism Negative Regulation Of Metabolic Process DNA Damage Checkpoint Signaling Positive Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Response To Radiation Signal Transduction In Response To DNA Damage Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Cellular Response To Oxygen-containing Compound Cell Cycle Phase Transition Intracellular Signal Transduction
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