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ACVRL1 and TGFBRAP1
Number of citations of the paper that reports this interaction (PubMedID
11278302
)
0
Data Source:
HPRD
(in vivo)
ACVRL1
TGFBRAP1
Description
activin A receptor like type 1
transforming growth factor beta receptor associated protein 1
Image
No pdb structure
GO Annotations
Cellular Component
Plasma Membrane
Cell Surface
Membrane
BMP Receptor Complex
Cytoplasm
Endosome
Early Endosome
Endomembrane System
Membrane
CORVET Complex
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta Receptor Activity
Transforming Growth Factor Beta Receptor Activity, Type I
Protein Binding
ATP Binding
Kinase Activity
Activin Receptor Activity, Type I
Transferase Activity
Protein Kinase Binding
SMAD Binding
Metal Ion Binding
Activin Binding
Transforming Growth Factor Beta Binding
BMP Receptor Activity
Transforming Growth Factor Beta Receptor Binding
Protein Binding
SMAD Binding
Biological Process
Angiogenesis
In Utero Embryonic Development
Regulation Of Endothelial Cell Proliferation
Negative Regulation Of Endothelial Cell Proliferation
Positive Regulation Of Endothelial Cell Proliferation
Lymphangiogenesis
Blood Vessel Maturation
Blood Vessel Remodeling
Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Endocardial Cushion Morphogenesis
Regulation Of DNA Replication
Regulation Of DNA-templated Transcription
Negative Regulation Of Cell Adhesion
Signal Transduction
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Heart Development
Blood Circulation
Regulation Of Blood Pressure
Negative Regulation Of Cell Population Proliferation
Dorsal/ventral Pattern Formation
Negative Regulation Of Endothelial Cell Migration
Negative Regulation Of Gene Expression
Cell Differentiation
Negative Regulation Of Cell Growth
Negative Regulation Of Cell Migration
BMP Signaling Pathway
Positive Regulation Of BMP Signaling Pathway
Positive Regulation Of Epithelial Cell Differentiation
Positive Regulation Of Chondrocyte Differentiation
Activin Receptor Signaling Pathway
Wound Healing, Spreading Of Epidermal Cells
Dorsal Aorta Morphogenesis
Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Endothelial Cell Differentiation
Positive Regulation Of Cell Differentiation
Negative Regulation Of Endothelial Cell Differentiation
Positive Regulation Of Endothelial Cell Differentiation
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Angiogenesis
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Blood Vessel Morphogenesis
Positive Regulation Of Multicellular Organismal Process
Negative Regulation Of Focal Adhesion Assembly
Positive Regulation Of SMAD Protein Signal Transduction
Epithelial Tube Morphogenesis
Lymphatic Endothelial Cell Differentiation
Artery Development
Venous Blood Vessel Development
Endothelial Tube Morphogenesis
Retina Vasculature Development In Camera-type Eye
Cellular Response To Growth Factor Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Cellular Response To BMP Stimulus
Circulatory System Development
Endocardial Cushion To Mesenchymal Transition
Positive Regulation Of Bicellular Tight Junction Assembly
Regulation Of Multicellular Organismal Development
Regulation Of DNA-templated Transcription
Intracellular Protein Transport
Autophagy
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Endosome To Lysosome Transport
Protein Transport
Vesicle-mediated Transport
Endosomal Vesicle Fusion
Regulation Of SNARE Complex Assembly
Pathways
Signaling by BMP
Drugs
ATP
Diseases
Hereditary hemorrhagic telangiectasia (HHT)
GWAS
Appendicular lean mass (
33097823
)
Hematocrit (
29403010
)
Hemoglobin (
32888494
29403010
)
Hemoglobin levels (
32327693
)
Lymphocyte count (
32888494
)
Medication use (HMG CoA reductase inhibitors) (
31015401
)
Monocyte count (
32888494
27863252
)
Myeloid white cell count (
27863252
)
Neutrophil count (
32888494
)
Platelet count (
32888494
)
Plateletcrit (
27863252
32888494
)
Urate levels (
23263486
)
White blood cell count (
27863252
32888494
)
AIDS (
19754311
)
Body mass index (
26426971
)
Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) (
31374203
)
Gut microbiota relative abundance (Coprococcus) (
33208821
)
Menarche (age at onset) (
27182965
)
Obesity-related traits (
23251661
)
Preeclampsia (
23551011
)
Walking pace (
33128006
)
Interacting Genes
15 interacting genes:
ACVR2A
BAMBI
CSNK2B
EIF4E
FKBP1A
GDF2
RNF31
SMAD1
SNX6
TGFB1
TGFB3
TGFBR1
TGFBR2
TGFBRAP1
XIAP
9 interacting genes:
ACVR1B
ACVR2B
ACVRL1
ALOX5
BMPR1A
SMAD2
SMAD4
TGFBR1
TGFBR2
Entrez ID
94
9392
HPRD ID
03181
06948
Ensembl ID
ENSG00000139567
ENSG00000135966
Uniprot IDs
A0A0S2Z2Y4
A0A0S2Z310
H3BTZ2
P37023
Q8WUH2
PDB IDs
2LCR
3MY0
4FAO
6SF1
6SF2
6SF3
7PPC
Enriched GO Terms of Interacting Partners
?
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Positive Regulation Of SMAD Protein Signal Transduction
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of SMAD Protein Signal Transduction
Type I Transforming Growth Factor Beta Receptor Binding
Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Cellular Response To Growth Factor Stimulus
Type II Transforming Growth Factor Beta Receptor Binding
Response To Growth Factor
Transforming Growth Factor Beta Receptor Binding
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Epithelial To Mesenchymal Transition
Type III Transforming Growth Factor Beta Receptor Binding
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Activin Receptor Signaling Pathway
Activin Receptor Complex
Activin Receptor Activity, Type I
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Epithelial To Mesenchymal Transition
Activin Binding
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Cell Differentiation
I-SMAD Binding
Positive Regulation Of Vasculature Development
Regulation Of Cartilage Development
Regulation Of Signal Transduction
Transforming Growth Factor Beta Binding
Tissue Morphogenesis
Regulation Of Metabolic Process
Regulation Of Primary Metabolic Process
Anatomical Structure Morphogenesis
Response To Cholesterol
Regulation Of Activin Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Gland Morphogenesis
Transforming Growth Factor Beta Ligand-receptor Complex
Regulation Of Cell Differentiation
Signal Transduction
Animal Organ Morphogenesis
Positive Regulation Of Multicellular Organismal Process
Langerhans Cell Differentiation
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Activin Receptor Signaling Pathway
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
SMAD Binding
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Activin Binding
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Response To Growth Factor
Roof Of Mouth Development
Activin Receptor Complex
Activin Receptor Activity, Type I
Transforming Growth Factor Beta Receptor Signaling Pathway
In Utero Embryonic Development
Chordate Embryonic Development
Positive Regulation Of SMAD Protein Signal Transduction
Embryo Development Ending In Birth Or Egg Hatching
Multicellular Organism Development
Cellular Response To Growth Factor Stimulus
I-SMAD Binding
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of SMAD Protein Signal Transduction
Endocardial Cushion Morphogenesis
Positive Regulation Of Developmental Process
Transforming Growth Factor Beta Receptor Activity, Type I
Positive Regulation Of Cell Differentiation
Heart Development
Regionalization
Negative Regulation Of Developmental Process
Regulation Of Cell Differentiation
Regulation Of Ossification
Trophoblast Cell Migration
Ventricular Septum Morphogenesis
Positive Regulation Of Multicellular Organismal Process
Transforming Growth Factor Beta Receptor Activity
Gastrulation
Anterior/posterior Pattern Specification
Mesoderm Development
Protein Serine/threonine Kinase Activity
Pattern Specification Process
Positive Regulation Of Epithelial To Mesenchymal Transition
Cell Surface Receptor Signaling Pathway
Tissue Morphogenesis
Artery Morphogenesis
Secondary Palate Development
Embryonic Morphogenesis
Receptor Complex
Anatomical Structure Formation Involved In Morphogenesis
Response To Transforming Growth Factor Beta
Cardiac Septum Morphogenesis
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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