ACVRL1 and TGFB3

Number of citations of the paper that reports this interaction (PubMedID 10187774)
0

Data Source:
HPRD (in vitro)

		ACVRL1	TGFB3
Description		activin A receptor like type 1	transforming growth factor beta 3
Image
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane BMP Receptor Complex	Extracellular Region Extracellular Space Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Kinase Activity Activin Receptor Activity, Type I Transferase Activity Protein Kinase Binding SMAD Binding Metal Ion Binding Activin Binding Transforming Growth Factor Beta Binding BMP Receptor Activity	Type II Transforming Growth Factor Beta Receptor Binding Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Type I Transforming Growth Factor Beta Receptor Binding Type III Transforming Growth Factor Beta Receptor Binding Identical Protein Binding Transforming Growth Factor Beta Binding
	Biological Process	Angiogenesis In Utero Embryonic Development Regulation Of Endothelial Cell Proliferation Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Lymphangiogenesis Blood Vessel Maturation Blood Vessel Remodeling Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Endocardial Cushion Morphogenesis Regulation Of DNA Replication Regulation Of DNA-templated Transcription Negative Regulation Of Cell Adhesion Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Heart Development Blood Circulation Regulation Of Blood Pressure Negative Regulation Of Cell Population Proliferation Dorsal/ventral Pattern Formation Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Gene Expression Cell Differentiation Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Epithelial Cell Differentiation Positive Regulation Of Chondrocyte Differentiation Activin Receptor Signaling Pathway Wound Healing, Spreading Of Epidermal Cells Dorsal Aorta Morphogenesis Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Endothelial Cell Differentiation Positive Regulation Of Cell Differentiation Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Blood Vessel Morphogenesis Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of SMAD Protein Signal Transduction Epithelial Tube Morphogenesis Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Endothelial Tube Morphogenesis Retina Vasculature Development In Camera-type Eye Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To BMP Stimulus Circulatory System Development Endocardial Cushion To Mesenchymal Transition Positive Regulation Of Bicellular Tight Junction Assembly Regulation Of Multicellular Organismal Development	Response To Hypoxia In Utero Embryonic Development Transforming Growth Factor Beta Receptor Signaling Pathway Salivary Gland Morphogenesis Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Macrophage Cytokine Production Mammary Gland Development Response To Progesterone Positive Regulation Of Collagen Biosynthetic Process Regulation Of Cell Population Proliferation Odontogenesis Uterine Wall Breakdown Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Cell-cell Junction Organization Positive Regulation Of Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Positive Regulation Of Protein Secretion Positive Regulation Of Cellular Component Organization Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Filopodium Assembly Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Cell Division Face Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Secondary Palate Development Detection Of Hypoxia Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Tight Junction Disassembly
Pathways		Signaling by BMP	Platelet degranulation Molecules associated with elastic fibres TGF-beta receptor signaling activates SMADs ECM proteoglycans
Drugs		ATP	1,4-Dioxane
Diseases		Hereditary hemorrhagic telangiectasia (HHT)	Arrhythmogenic right ventricular cardiomyopathy (ARVC) Graft-versus-host disease Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Allograft rejection Ossification of the posterior longitudinal ligament of spine (OPLL)
GWAS		Appendicular lean mass ( 33097823) Hematocrit ( 29403010) Hemoglobin ( 32888494 29403010) Hemoglobin levels ( 32327693) Lymphocyte count ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Monocyte count ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 27863252 32888494) Urate levels ( 23263486) White blood cell count ( 27863252 32888494)	Height ( 33713608)
Interacting Genes		15 interacting genes: ACVR2A BAMBI CSNK2B EIF4E FKBP1A GDF2 RNF31 SMAD1 SNX6 TGFB1 TGFB3 TGFBR1 TGFBR2 TGFBRAP1 XIAP	13 interacting genes: ACVRL1 CCL20 CCN2 CHMP2A ENG FMOD LTBP3 SDC4 TGFB2 TGFBR1 TGFBR2 TGFBR3 VASN
Entrez ID		94	7043
HPRD ID		03181	01829
Ensembl ID		ENSG00000139567	ENSG00000119699
Uniprot IDs		A0A0S2Z2Y4 A0A0S2Z310 H3BTZ2 P37023	A5YM40 B3KVH9 P10600
PDB IDs		2LCR 3MY0 4FAO 6SF1 6SF2 6SF3 7PPC	1KTZ 1TGJ 1TGK 2PJY 3EO1 4UM9 8V52 8VS6 8VSB 9B9F 9FK5
Enriched GO Terms of Interacting Partners?		Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of SMAD Protein Signal Transduction Type I Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cellular Response To Growth Factor Stimulus Type II Transforming Growth Factor Beta Receptor Binding Response To Growth Factor Transforming Growth Factor Beta Receptor Binding Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Type III Transforming Growth Factor Beta Receptor Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Activin Receptor Signaling Pathway Activin Receptor Complex Activin Receptor Activity, Type I Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Epithelial To Mesenchymal Transition Activin Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Differentiation I-SMAD Binding Positive Regulation Of Vasculature Development Regulation Of Cartilage Development Regulation Of Signal Transduction Transforming Growth Factor Beta Binding Tissue Morphogenesis Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Anatomical Structure Morphogenesis Response To Cholesterol Regulation Of Activin Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Gland Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex Regulation Of Cell Differentiation Signal Transduction Animal Organ Morphogenesis Positive Regulation Of Multicellular Organismal Process Langerhans Cell Differentiation	Transforming Growth Factor Beta Binding Activin Binding Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Regulation Of SMAD Protein Signal Transduction Cardiac Epithelial To Mesenchymal Transition Transforming Growth Factor Beta Receptor Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Epithelial To Mesenchymal Transition Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Type II Transforming Growth Factor Beta Receptor Binding Mesenchymal Cell Differentiation Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Artery Morphogenesis Endocardial Cushion Morphogenesis Heart Trabecula Morphogenesis Regulation Of Cartilage Development Cardiac Septum Morphogenesis Enzyme-linked Receptor Protein Signaling Pathway Blood Vessel Morphogenesis Activin Receptor Activity, Type I Regulation Of Epithelial To Mesenchymal Transition Ventricular Septum Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis SMAD Binding Cell Migration Negative Regulation Of Epithelial Cell Proliferation Regulation Of Chondrocyte Differentiation Transmembrane Receptor Protein Serine/threonine Kinase Activity Cardiac Muscle Tissue Morphogenesis Secondary Palate Development Regulation Of Cell Migration Positive Regulation Of Epithelial To Mesenchymal Transition Ventricular Trabecula Myocardium Morphogenesis Cell Surface Regulation Of Cell Motility Cell Motility Regulation Of Locomotion Muscle Tissue Morphogenesis Wound Healing Tissue Morphogenesis Response To Wounding Roof Of Mouth Development Tissue Development Glycosaminoglycan Binding
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