GDF5 and BMPR1A

Number of citations of the paper that reports this interaction (PMID 11282024)
29

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		GDF5	BMPR1A
Gene Name		growth differentiation factor 5	bone morphogenetic protein receptor, type IA
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane	Plasma Membrane Caveola Integral Component Of Membrane Dendrite Neuronal Cell Body
	Molecular Function	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Identical Protein Binding	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Protein Homodimerization Activity SMAD Binding Metal Ion Binding
	Biological Process	Chondrocyte Differentiation Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Extracellular Matrix Organization Embryonic Limb Morphogenesis BMP Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Forelimb Morphogenesis Hindlimb Morphogenesis Growth Regulation Of Multicellular Organism Growth Regulation Of Apoptotic Process Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Differentiation Cell Development Negative Regulation Of Epithelial Cell Proliferation SMAD Protein Signal Transduction Negative Regulation Of Mesenchymal Cell Apoptotic Process	In Utero Embryonic Development Mesoderm Formation Somitogenesis Mullerian Duct Regression Positive Regulation Of Mesenchymal Cell Proliferation Endocardial Cushion Formation Transcription From RNA Polymerase II Promoter Protein Phosphorylation Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Ectoderm Development Dorsal/ventral Axis Specification Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Neural Crest Cell Development Stem Cell Maintenance Pituitary Gland Development Neural Plate Mediolateral Regionalization Signal Transduction By Phosphorylation Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Hindlimb Morphogenesis Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Paraxial Mesoderm Structural Organization Lateral Mesoderm Development Regulation Of Lateral Mesodermal Cell Fate Specification Mesendoderm Development Embryonic Organ Development Developmental Growth Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Neurogenesis Cartilage Development Palate Development Positive Regulation Of SMAD Protein Import Into Nucleus Heart Formation Regulation Of Cellular Senescence
Pathways		Molecules associated with elastic fibres Elastic fibre formation	Signaling by BMP
Drugs
Diseases
GWAS		Height ( 20881960 23563607 18391950 18391951 18391952 20189936)
Protein-Protein Interactions		8 interactors: ACVR1 ACVR2A ACVR2B BMPR1A BMPR1B BMPR2 CHRDL2 HTRA1	23 interactors: ACVR1 BAMBI BMP2 BMP4 BMP5 BMP6 BMP7 BMPR1B BMPR2 FKBP1A FKBP1B GDF5 GDF6 GDF9 HOXC8 NEDD4 NEDD4L SF3B4 SMAD1 TAB1 TGFBRAP1 USP15 ZMYND11
Entrez ID		8200	657
HPRD ID		03092	03192
Ensembl ID		ENSG00000125965
Uniprot IDs		P43026	P36894
PDB IDs		1WAQ 2BHK 3EVS 3QB4	1ES7 1REW 2GOO 2H62 2H64 2K3G 2QJ9 2QJA 2QJB 3NH7 3QB4
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation BMP Signaling Pathway Positive Regulation Of Ossification Regulation Of Osteoblast Differentiation Regulation Of Ossification Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signal Transduction By Phosphorylation Activin Receptor Signaling Pathway Mesoderm Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Gastrulation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Pattern Specification Process Skeletal System Development Regulation Of BMP Signaling Pathway Regulation Of Signal Transduction Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Cell Differentiation Organ Development Enzyme Linked Receptor Protein Signaling Pathway Tissue Development Regulation Of Signaling Negative Regulation Of Chondrocyte Proliferation Organ Morphogenesis Cartilage Development Gastrulation With Mouth Forming Second Positive Regulation Of Signal Transduction Connective Tissue Development Embryonic Morphogenesis Protein Phosphorylation Anterior/posterior Pattern Specification Anatomical Structure Morphogenesis System Development Positive Regulation Of Protein Phosphorylation Endothelial Cell Differentiation Regulation Of Cell Differentiation Positive Regulation Of Activin Receptor Signaling Pathway Mesoderm Formation Multicellular Organismal Development Lymphatic Endothelial Cell Differentiation Mesoderm Morphogenesis Endothelium Development Positive Regulation Of Phosphorylation Anatomical Structure Development Positive Regulation Of Protein Modification Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Determination Of Left/right Symmetry	Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Signal Transduction Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Cartilage Development Positive Regulation Of Bone Mineralization Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Positive Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signaling Cartilage Development Cell Surface Receptor Signaling Pathway Regulation Of RNA Metabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Neuron Differentiation Regulation Of Osteoblast Differentiation Regulation Of Signal Transduction Positive Regulation Of Cell Development Regulation Of Bone Mineralization Positive Regulation Of Protein Metabolic Process Connective Tissue Development Regulation Of Gene Expression Regulation Of Neuron Differentiation Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cartilage Development Regulation Of Transcription, DNA-templated Positive Regulation Of Neurogenesis Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of Cell Development Regulation Of Phosphorus Metabolic Process Regulation Of Ossification Positive Regulation Of Protein Modification Process Growth Regulation Of Neurogenesis Regulation Of Cell Differentiation Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Response To Organic Substance Skeletal System Development
Tagcloud ?		astroglial augments cns damages debated degenerate dissected dopaminergic etiology expresed gdnf glial indirectly mesencephalon methylpyridinium midbrain multifunctional neurons neurotrophic parkinson pd protects selectively superfamily supports tgf transforming triggered trophic	abundant adenomatosis apcdd1 bmp5 closure destinies dictated dkk2 e15 edge eyelid eyelids fetuses fgfr2 gli2 identities ie jag1 lcm le microdissection morphogenetic notch1 opening polyposis ptch1 shh smo tip
Tagcloud (Difference) ?		astroglial augments cns damages debated degenerate dissected dopaminergic etiology expresed gdnf glial indirectly mesencephalon methylpyridinium midbrain multifunctional neurons neurotrophic parkinson pd protects selectively superfamily supports tgf transforming triggered trophic	abundant adenomatosis apcdd1 bmp5 closure destinies dictated dkk2 e15 edge eyelid eyelids fetuses fgfr2 gli2 identities ie jag1 lcm le microdissection morphogenetic notch1 opening polyposis ptch1 shh smo tip
Tagcloud (Intersection) ?