GDF5 and HTRA1

Number of citations of the paper that reports this interaction (PMID 14973287)
46

Data Source:
HPRD (in vitro)

		GDF5	HTRA1
Gene Name		growth differentiation factor 5	HtrA serine peptidase 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane	Extracellular Space Cytosol Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Identical Protein Binding	Serine-type Endopeptidase Activity Insulin-like Growth Factor Binding Serine-type Peptidase Activity
	Biological Process	Chondrocyte Differentiation Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Extracellular Matrix Organization Embryonic Limb Morphogenesis BMP Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Forelimb Morphogenesis Hindlimb Morphogenesis Growth Regulation Of Multicellular Organism Growth Regulation Of Apoptotic Process Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Differentiation Cell Development Negative Regulation Of Epithelial Cell Proliferation SMAD Protein Signal Transduction Negative Regulation Of Mesenchymal Cell Apoptotic Process	Regulation Of Cell Growth Proteolysis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Defense Response To Virus Dentinogenesis
Pathways		Molecules associated with elastic fibres Elastic fibre formation
Drugs
Diseases
GWAS		Height ( 20881960 23563607 18391950 18391951 18391952 20189936)	Age-related macular degeneration ( 20385819 20385826 22694956 23326517 23455636 23536807 20861866 21665990) Age-related macular degeneration (CNV vs. GA) ( 22705344) Age-related macular degeneration (CNV) ( 22705344) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (GA) ( 22705344) Age-related macular degeneration (wet) ( 17053108)
Protein-Protein Interactions		8 interactors: ACVR1 ACVR2A ACVR2B BMPR1A BMPR1B BMPR2 CHRDL2 HTRA1	18 interactors: APOE BMP4 CAST CDYL COL1A1 COL2A1 COL3A1 COX5A CSNK2B FAM46A FCHSD2 GDF5 GOLGA2 IMPDH1 LRP10 NOS3 PARD6B XIAP
Entrez ID		8200	5654
HPRD ID		03092	03725
Ensembl ID		ENSG00000125965	ENSG00000166033
Uniprot IDs		P43026	Q92743
PDB IDs		1WAQ 2BHK 3EVS 3QB4	2JOA 2YTW 3NUM 3NWU 3NZI 3TJN 3TJO 3TJQ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation BMP Signaling Pathway Positive Regulation Of Ossification Regulation Of Osteoblast Differentiation Regulation Of Ossification Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signal Transduction By Phosphorylation Activin Receptor Signaling Pathway Mesoderm Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Gastrulation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Pattern Specification Process Skeletal System Development Regulation Of BMP Signaling Pathway Regulation Of Signal Transduction Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Cell Differentiation Organ Development Enzyme Linked Receptor Protein Signaling Pathway Tissue Development Regulation Of Signaling Negative Regulation Of Chondrocyte Proliferation Organ Morphogenesis Cartilage Development Gastrulation With Mouth Forming Second Positive Regulation Of Signal Transduction Connective Tissue Development Embryonic Morphogenesis Protein Phosphorylation Anterior/posterior Pattern Specification Anatomical Structure Morphogenesis System Development Positive Regulation Of Protein Phosphorylation Endothelial Cell Differentiation Regulation Of Cell Differentiation Positive Regulation Of Activin Receptor Signaling Pathway Mesoderm Formation Multicellular Organismal Development Lymphatic Endothelial Cell Differentiation Mesoderm Morphogenesis Endothelium Development Positive Regulation Of Phosphorylation Anatomical Structure Development Positive Regulation Of Protein Modification Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Determination Of Left/right Symmetry	Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Presynaptic Membrane Organization Anatomical Structure Morphogenesis Cell Development Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cellular Response To Growth Factor Stimulus Regulation Of Cell Migration Response To Growth Factor Negative Regulation Of Cell Death Regulation Of Cell Motility Endochondral Ossification Regulation Of Signal Transduction Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Presynaptic Membrane Organization Generation Of Neurons Regulation Of Locomotion Regulation Of Cellular Component Movement Neuron Differentiation Cell Morphogenesis Involved In Differentiation Limb Morphogenesis Neurogenesis Regulation Of Pathway-restricted SMAD Protein Phosphorylation Artery Morphogenesis Cartilage Development Regulation Of Signaling Limb Development Collagen Fibril Organization Collagen Catabolic Process Artery Development Neuron Projection Development Regulation Of Cell Development Cellular Response To Organic Substance Cardiovascular System Development Blood Vessel Development Connective Tissue Development Collagen Metabolic Process Regulation Of Cellular Protein Metabolic Process Cell Differentiation Endochondral Bone Morphogenesis Endothelial Tube Morphogenesis Vasculature Development Multicellular Organismal Macromolecule Metabolic Process Chondrocyte Differentiation Skeletal System Development Multicellular Organismal Metabolic Process Neuron Development Regulation Of Apoptotic Process Axon Development
Tagcloud ?		astroglial augments cns damages debated degenerate dissected dopaminergic etiology expresed gdnf glial indirectly mesencephalon methylpyridinium midbrain multifunctional neurons neurotrophic parkinson pd protects selectively superfamily supports tgf transforming triggered trophic	amd arteriopathy biosynthetic carasil elevates elucidating fibulin fostered hits infarcts interplay ix leukoencephalopathy macular metalloporphyrin modulators mpps multitude oligomerization porphyrin porphyrins ppp protoporphyria protoporphyrin seek shed subcortical unravel
Tagcloud (Difference) ?		astroglial augments cns damages debated degenerate dissected dopaminergic etiology expresed gdnf glial indirectly mesencephalon methylpyridinium midbrain multifunctional neurons neurotrophic parkinson pd protects selectively superfamily supports tgf transforming triggered trophic	amd arteriopathy biosynthetic carasil elevates elucidating fibulin fostered hits infarcts interplay ix leukoencephalopathy macular metalloporphyrin modulators mpps multitude oligomerization porphyrin porphyrins ppp protoporphyria protoporphyrin seek shed subcortical unravel
Tagcloud (Intersection) ?