GDF5 and BMPR2

Number of citations of the paper that reports this interaction (PMID 9525338)
18

Data Source:
HPRD (in vitro)

		GDF5	BMPR2
Gene Name		growth differentiation factor 5	bone morphogenetic protein receptor, type II (serine/threonine kinase)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Caveola Basal Plasma Membrane Cell Surface Apical Plasma Membrane Dendrite Neuronal Cell Body Spanning Component Of Plasma Membrane
	Molecular Function	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Identical Protein Binding	Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Activin Receptor Activity, Type II Growth Factor Binding Metal Ion Binding
	Biological Process	Chondrocyte Differentiation Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Extracellular Matrix Organization Embryonic Limb Morphogenesis BMP Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Forelimb Morphogenesis Hindlimb Morphogenesis Growth Regulation Of Multicellular Organism Growth Regulation Of Apoptotic Process Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Differentiation Cell Development Negative Regulation Of Epithelial Cell Proliferation SMAD Protein Signal Transduction Negative Regulation Of Mesenchymal Cell Apoptotic Process	Mesoderm Formation Positive Regulation Of Endothelial Cell Proliferation Lymphangiogenesis Blood Vessel Remodeling Chondrocyte Development Negative Regulation Of Systemic Arterial Blood Pressure Transcription From RNA Polymerase II Promoter Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Brain Development Cellular Response To Starvation Anterior/posterior Pattern Specification Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Lung Blood Pressure Signal Transduction By Phosphorylation Proteoglycan Biosynthetic Process Negative Regulation Of Cell Growth Positive Regulation Of Bone Mineralization BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Activin Receptor Signaling Pathway Regulation Of Cell Proliferation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Vasoconstriction Vascular Endothelial Growth Factor Receptor Signaling Pathway Lung Alveolus Development Positive Regulation Of Axon Extension Involved In Axon Guidance Limb Development Endochondral Bone Morphogenesis Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Positive Regulation Of Cartilage Development Retina Vasculature Development In Camera-type Eye Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of DNA Biosynthetic Process
Pathways		Molecules associated with elastic fibres Elastic fibre formation	Signaling by BMP
Drugs
Diseases
GWAS		Height ( 20881960 23563607 18391950 18391951 18391952 20189936)	Urate levels ( 23263486)
Protein-Protein Interactions		8 interactors: ACVR1 ACVR2A ACVR2B BMPR1A BMPR1B BMPR2 CHRDL2 HTRA1	49 interactors: ACTR8 ACVR1 ACVR1B ARSA BMP10 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR1B C4BPA CCDC89 CES1 CRYAB CTBP1 DYNLT1 FHL2 FOXL1 FRS3 GDF2 GDF5 GDF6 GDF9 HNRNPR LIMK1 LMX1A LSM10 LSP1 MAP3K8 MAPK8 MERTK MOS NBEA NOP56 PDZRN3 PMPCA PPP1CC PRKCB RABGGTA SULT1E1 TGFBR1 TOPBP1 TRIB3 TRPC1 TSR1 TUBB TUBB4A TWF1
Entrez ID		8200	659
HPRD ID		03092	02880
Ensembl ID		ENSG00000125965	ENSG00000204217
Uniprot IDs		P43026	Q13873
PDB IDs		1WAQ 2BHK 3EVS 3QB4	2HLQ 3G2F
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation BMP Signaling Pathway Positive Regulation Of Ossification Regulation Of Osteoblast Differentiation Regulation Of Ossification Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signal Transduction By Phosphorylation Activin Receptor Signaling Pathway Mesoderm Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Gastrulation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Pattern Specification Process Skeletal System Development Regulation Of BMP Signaling Pathway Regulation Of Signal Transduction Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Cell Differentiation Organ Development Enzyme Linked Receptor Protein Signaling Pathway Tissue Development Regulation Of Signaling Negative Regulation Of Chondrocyte Proliferation Organ Morphogenesis Cartilage Development Gastrulation With Mouth Forming Second Positive Regulation Of Signal Transduction Connective Tissue Development Embryonic Morphogenesis Protein Phosphorylation Anterior/posterior Pattern Specification Anatomical Structure Morphogenesis System Development Positive Regulation Of Protein Phosphorylation Endothelial Cell Differentiation Regulation Of Cell Differentiation Positive Regulation Of Activin Receptor Signaling Pathway Mesoderm Formation Multicellular Organismal Development Lymphatic Endothelial Cell Differentiation Mesoderm Morphogenesis Endothelium Development Positive Regulation Of Phosphorylation Anatomical Structure Development Positive Regulation Of Protein Modification Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Determination Of Left/right Symmetry	Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway SMAD Protein Signal Transduction Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Activin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Ossification Protein Phosphorylation Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Cell Development Regulation Of Bone Mineralization Regulation Of MAPK Cascade Regulation Of Osteoblast Differentiation Regulation Of Phosphorylation Regulation Of Cell Differentiation Phosphorylation Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Phosphorus Metabolic Process Growth Signal Transduction By Phosphorylation Regulation Of Signal Transduction Cartilage Development Regulation Of Ossification Positive Regulation Of Cell Differentiation Regulation Of Cellular Component Organization Regulation Of Signaling Regulation Of Cartilage Development Regulation Of Growth Cell Surface Receptor Signaling Pathway Connective Tissue Development Positive Regulation Of Cartilage Development Phosphate-containing Compound Metabolic Process Peptidyl-threonine Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Response To Stimulus
Tagcloud ?		astroglial augments cns damages debated degenerate dissected dopaminergic etiology expresed gdnf glial indirectly mesencephalon methylpyridinium midbrain multifunctional neurons neurotrophic parkinson pd protects selectively superfamily supports tgf transforming triggered trophic	apoptotic autophagy bmprs bmps chondrosarcoma chondrosarcomas clinicopathological crucial dedifferentiated eventually find g2 inconsistent interfering mdm2 morphogenetic multifunctional predict prevalent promoted protective repression sensitized silencing somewhat tumorigenesis tumorigenicity xiap
Tagcloud (Difference) ?		astroglial augments cns damages debated degenerate dissected dopaminergic etiology expresed gdnf glial indirectly mesencephalon methylpyridinium midbrain neurons neurotrophic parkinson pd protects selectively superfamily supports tgf transforming triggered trophic	apoptotic autophagy bmprs bmps chondrosarcoma chondrosarcomas clinicopathological crucial dedifferentiated eventually find g2 inconsistent interfering mdm2 morphogenetic predict prevalent promoted protective repression sensitized silencing somewhat tumorigenesis tumorigenicity xiap
Tagcloud (Intersection) ?		multifunctional