GDF5 and CHRDL2

Number of citations of the paper that reports this interaction (PMID 14660436)
14

Data Source:
HPRD (in vivo)

		GDF5	CHRDL2
Gene Name		growth differentiation factor 5	chordin-like 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane	Extracellular Space Cytoplasm
	Molecular Function	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Identical Protein Binding
	Biological Process	Chondrocyte Differentiation Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Extracellular Matrix Organization Embryonic Limb Morphogenesis BMP Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Forelimb Morphogenesis Hindlimb Morphogenesis Growth Regulation Of Multicellular Organism Growth Regulation Of Apoptotic Process Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Differentiation Cell Development Negative Regulation Of Epithelial Cell Proliferation SMAD Protein Signal Transduction Negative Regulation Of Mesenchymal Cell Apoptotic Process	Ossification Cell Differentiation Negative Regulation Of BMP Signaling Pathway Cartilage Development
Pathways		Molecules associated with elastic fibres Elastic fibre formation
Drugs
Diseases
GWAS		Height ( 20881960 23563607 18391950 18391951 18391952 20189936)
Protein-Protein Interactions		8 interactors: ACVR1 ACVR2A ACVR2B BMPR1A BMPR1B BMPR2 CHRDL2 HTRA1	7 interactors: BMP2 BMP4 BMP5 BMP6 BMP7 GDF5 INHBA
Entrez ID		8200	25884
HPRD ID		03092	09881
Ensembl ID		ENSG00000125965	ENSG00000054938
Uniprot IDs		P43026	Q6WN34
PDB IDs		1WAQ 2BHK 3EVS 3QB4
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation BMP Signaling Pathway Positive Regulation Of Ossification Regulation Of Osteoblast Differentiation Regulation Of Ossification Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signal Transduction By Phosphorylation Activin Receptor Signaling Pathway Mesoderm Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Gastrulation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Pattern Specification Process Skeletal System Development Regulation Of BMP Signaling Pathway Regulation Of Signal Transduction Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Cell Differentiation Organ Development Enzyme Linked Receptor Protein Signaling Pathway Tissue Development Regulation Of Signaling Negative Regulation Of Chondrocyte Proliferation Organ Morphogenesis Cartilage Development Gastrulation With Mouth Forming Second Positive Regulation Of Signal Transduction Connective Tissue Development Embryonic Morphogenesis Protein Phosphorylation Anterior/posterior Pattern Specification Anatomical Structure Morphogenesis System Development Positive Regulation Of Protein Phosphorylation Endothelial Cell Differentiation Regulation Of Cell Differentiation Positive Regulation Of Activin Receptor Signaling Pathway Mesoderm Formation Multicellular Organismal Development Lymphatic Endothelial Cell Differentiation Mesoderm Morphogenesis Endothelium Development Positive Regulation Of Phosphorylation Anatomical Structure Development Positive Regulation Of Protein Modification Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Determination Of Left/right Symmetry	Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Growth Cartilage Development Connective Tissue Development Regulation Of MAPK Cascade Positive Regulation Of Protein Phosphorylation Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of Neurogenesis Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Cartilage Development Regulation Of Protein Phosphorylation Glandular Epithelial Cell Differentiation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell Development Regulation Of Neuron Differentiation Positive Regulation Of Protein Metabolic Process Skeletal System Development Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Cell Proliferation Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Cell Proliferation Involved In Kidney Development Ossification Regulation Of Neurogenesis Regulation Of Epithelial Cell Proliferation Regulation Of Cell Death Regulation Of Cell Differentiation Regulation Of Cartilage Development Mesenchymal Cell Proliferation Positive Regulation Of DNA-dependent DNA Replication Positive Regulation Of Ossification Tissue Development Type B Pancreatic Cell Development Regulation Of Intracellular Signal Transduction Regulation Of Cell Development Cell Development Regulation Of Transcription From RNA Polymerase II Promoter
Tagcloud ?		astroglial augments cns damages debated degenerate dissected dopaminergic etiology expresed gdnf glial indirectly mesencephalon methylpyridinium midbrain multifunctional neurons neurotrophic parkinson pd protects selectively superfamily supports tgf transforming triggered trophic	affymetrix axin2 bglap2 bmp bridge cooperatively cpz csnk2a1 deformities fgfr1 fibrogenic fzd1 fzd2 groupings hgn id1 lef1 microdissection mmp9 osteogenic plate remodelling repaired sfrp1 sfrp4 spp1 tcf7 wisp1
Tagcloud (Difference) ?		astroglial augments cns damages debated degenerate dissected dopaminergic etiology expresed gdnf glial indirectly mesencephalon methylpyridinium midbrain multifunctional neurons neurotrophic parkinson pd protects selectively superfamily supports tgf transforming triggered trophic	affymetrix axin2 bglap2 bmp bridge cooperatively cpz csnk2a1 deformities fgfr1 fibrogenic fzd1 fzd2 groupings hgn id1 lef1 microdissection mmp9 osteogenic plate remodelling repaired sfrp1 sfrp4 spp1 tcf7 wisp1
Tagcloud (Intersection) ?