IGSF1 and RANBP10

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
HPRD (two hybrid)

		IGSF1	RANBP10
Description		immunoglobulin superfamily member 1	RAN binding protein 10
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Membrane	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Microtubule Cytoskeleton
	Molecular Function	Protein Binding Inhibin Binding Activin Receptor Antagonist Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding Beta-tubulin Binding
	Biological Process	Immune Response-regulating Signaling Pathway Regulation Of DNA-templated Transcription Negative Regulation Of Activin Receptor Signaling Pathway	Microtubule Cytoskeleton Organization Cytoskeleton Organization
Pathways			MET activates RAS signaling
Drugs
Diseases
GWAS		Age at voice drop ( 27182965) Menarche (age at onset) ( 27182965)	Empathy quotient ( 29527006) HDL cholesterol ( 25961943) Hematocrit ( 27863252 32888494) Hemoglobin concentration ( 27863252) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		8 interacting genes: ACVR1 ACVR1B ACVR2A ACVR2B HECTD1 IGF1 INHBB RANBP10	15 interacting genes: CACHD1 CNTNAP4 CTAG1A CTAG1B IGFBP6 IGSF1 MAGEA11 MEGF10 MET NEDD4 NEDD4L PRKCG RAN THSD7B TSEN2
Entrez ID		3547	57610
HPRD ID		02138	15207
Ensembl ID		ENSG00000147255	ENSG00000141084
Uniprot IDs		Q8N6C5	B3KP49 Q6VN20 R4GMX8
PDB IDs
Enriched GO Terms of Interacting Partners?		Activin Receptor Signaling Pathway Activin Receptor Complex Activin Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Activin Receptor Signaling Pathway Activin Receptor Activity Positive Regulation Of Activin Receptor Signaling Pathway Activin Receptor Activity, Type I Growth Factor Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Osteoblast Differentiation Gastrulation With Mouth Forming Second Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Ossification Regulation Of Osteoblast Differentiation Activin Receptor Activity, Type II Positive Regulation Of Bone Mineralization Negative Regulation Of Ossification Gastrulation Inhibin Binding Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Mesoderm Development Cellular Response To Growth Factor Stimulus Regulation Of Bone Mineralization BMP Receptor Activity Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Response To Growth Factor Determination Of Bilateral Symmetry Determination Of Left/right Symmetry Positive Regulation Of Signal Transduction Positive Regulation Of Cell Differentiation Protein Serine/threonine Kinase Activity Positive Regulation Of Multicellular Organismal Process Osteoblast Differentiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling System Development Protein Kinase Activity Cell Surface Receptor Signaling Pathway Regulation Of Reproductive Process Negative Regulation Of Multicellular Organismal Process Skeletal System Development Receptor Complex Endothelial Cell Differentiation Cellular Response To BMP Stimulus Kinase Activity	Sodium Channel Inhibitor Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Potassium Channel Inhibitor Activity Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Sodium Ion Transport TRNA Threonylcarbamoyladenosine Metabolic Process Receptor Catabolic Process Negative Regulation Of Potassium Ion Transmembrane Transport Postsynaptic Cytosol Negative Regulation Of Potassium Ion Transport Neuromuscular Junction Development TRNA Metabolic Process Insulin-like Growth Factor Binary Complex Hepatocyte Growth Factor Receptor Activity Receptor Metabolic Process Formation Of Structure Involved In A Symbiotic Process Activin Receptor Antagonist Activity Receptor Internalization Regulation Of Dendrite Morphogenesis Channel Inhibitor Activity Negative Regulation Of Cation Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Sodium Ion Transport Protein Monoubiquitination RNA Nuclear Export Complex SnRNA Import Into Nucleus Pre-miRNA Export From Nucleus TRNA-intron Lyase Activity
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