IGSF1 and INHBB

Number of citations of the paper that reports this interaction (PubMedID 11266516)
0

Data Source:
BioGRID (imaging technique)
HPRD (in vivo)

		IGSF1	INHBB
Description		immunoglobulin superfamily member 1	inhibin subunit beta B
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Membrane	Extracellular Region Extracellular Space Perinuclear Region Of Cytoplasm Cell Periphery
	Molecular Function	Protein Binding Inhibin Binding Activin Receptor Antagonist Activity	Cytokine Activity Hormone Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity Host Cell Surface Receptor Binding
	Biological Process	Immune Response-regulating Signaling Pathway Regulation Of DNA-templated Transcription Negative Regulation Of Activin Receptor Signaling Pathway	Ovarian Follicle Development Defense Response Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Spermatogenesis Male Gonad Development Female Gonad Development Cellular Response To Starvation Response To Wounding Response To Insecticide Pituitary Gland Development Cell Differentiation Negative Regulation Of Hepatocyte Growth Factor Production Cellular Response To Insulin Stimulus Activin Receptor Signaling Pathway Response To Gonadotropin Cellular Response To Leptin Stimulus Adhesion Of Symbiont To Host Cell Fat Cell Differentiation Negative Regulation Of Insulin Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Follicle-stimulating Hormone Secretion Oocyte Development Positive Regulation Of Ovulation Cellular Response To Calcium Ion Cellular Response To CAMP Cellular Response To Interleukin-1 Cellular Response To Cholesterol Seminiferous Tubule Development Cellular Response To Thyroid Hormone Stimulus Apoptotic Signaling Pathway Cellular Response To Thyroglobulin Triiodothyronine Cellular Response To Phorbol 13-acetate 12-myristate Positive Regulation Of Apoptotic Signaling Pathway
Pathways			Signaling by Activin Signaling by Activin Glycoprotein hormones Antagonism of Activin by Follistatin
Drugs
Diseases
GWAS		Age at voice drop ( 27182965) Menarche (age at onset) ( 27182965)	Age-related macular degeneration ( 23326517) Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Breast size ( 22747683 27182965) Obesity ( 21552555) Serum alkaline phosphatase levels ( 33547301) Urate levels ( 23263486 31985003)
Interacting Genes		8 interacting genes: ACVR1 ACVR1B ACVR2A ACVR2B HECTD1 IGF1 INHBB RANBP10	12 interacting genes: ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B BMPR2 CRIPTO FNTA IGSF1 INHA INHBA INHBC
Entrez ID		3547	3625
HPRD ID		02138	00934
Ensembl ID		ENSG00000147255	ENSG00000163083
Uniprot IDs		Q8N6C5	P09529
PDB IDs			7U5O
Enriched GO Terms of Interacting Partners?		Activin Receptor Signaling Pathway Activin Receptor Complex Activin Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Activin Receptor Signaling Pathway Activin Receptor Activity Positive Regulation Of Activin Receptor Signaling Pathway Activin Receptor Activity, Type I Growth Factor Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Osteoblast Differentiation Gastrulation With Mouth Forming Second Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Ossification Regulation Of Osteoblast Differentiation Activin Receptor Activity, Type II Positive Regulation Of Bone Mineralization Negative Regulation Of Ossification Gastrulation Inhibin Binding Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Mesoderm Development Cellular Response To Growth Factor Stimulus Regulation Of Bone Mineralization BMP Receptor Activity Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Response To Growth Factor Determination Of Bilateral Symmetry Determination Of Left/right Symmetry Positive Regulation Of Signal Transduction Positive Regulation Of Cell Differentiation Protein Serine/threonine Kinase Activity Positive Regulation Of Multicellular Organismal Process Osteoblast Differentiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling System Development Protein Kinase Activity Cell Surface Receptor Signaling Pathway Regulation Of Reproductive Process Negative Regulation Of Multicellular Organismal Process Skeletal System Development Receptor Complex Endothelial Cell Differentiation Cellular Response To BMP Stimulus Kinase Activity	Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Activin Receptor Complex Enzyme-linked Receptor Protein Signaling Pathway Inhibin Binding Activin Receptor Activity Growth Factor Binding Regulation Of Activin Receptor Signaling Pathway Activin Receptor Activity, Type I Activin Binding Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Activin Receptor Activity, Type II Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Response To Growth Factor Positive Regulation Of Activin Receptor Signaling Pathway Regulation Of Ossification BMP Receptor Activity Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Signal Transduction Nodal Signaling Pathway System Development Regulation Of SMAD Protein Signal Transduction Protein Serine/threonine Kinase Activity Positive Regulation Of Osteoblast Differentiation Gastrulation With Mouth Forming Second Regulation Of Bone Mineralization Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling BMP Signaling Pathway Determination Of Bilateral Symmetry Determination Of Left/right Symmetry Inhibin A Complex Protein Kinase Activity Regionalization Endothelial Cell Differentiation Cellular Response To BMP Stimulus Inhibin-betaglycan-ActRII Complex Negative Regulation Of Follicle-stimulating Hormone Secretion Nodal Binding Kinase Activity Positive Regulation Of Erythrocyte Differentiation
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