IGSF1 and INHBB

Number of citations of the paper that reports this interaction (PMID 11266516)
5

Data Source:
BioGRID (imaging technique)
HPRD (in vivo)

		IGSF1	INHBB
Gene Name		immunoglobulin superfamily, member 1	inhibin, beta B
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Perinuclear Region Of Cytoplasm
	Molecular Function	Receptor Activity Protein Binding Coreceptor Activity Inhibin Binding	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Hormone Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity Host Cell Surface Receptor Binding
	Biological Process	Regulation Of Transcription, DNA-templated Signal Transduction	Ovarian Follicle Development Defense Response Cellular Response To Starvation Response To Mechanical Stimulus Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cell Differentiation Cellular Response To Insulin Stimulus Activin Receptor Signaling Pathway Growth Regulation Of Apoptotic Process Regulation Of MAPK Cascade Cellular Response To Leptin Stimulus Fat Cell Differentiation Negative Regulation Of Insulin Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Hepatocyte Growth Factor Biosynthetic Process Cell Development Oocyte Development Positive Regulation Of Ovulation SMAD Protein Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway
Pathways			Antagonism of Activin by Follistatin Peptide hormone metabolism Glycoprotein hormones Signaling by Activin Peptide hormone biosynthesis
Drugs
Diseases
GWAS			Age-related macular degeneration ( 23326517) Breast size ( 22747683) Obesity ( 21552555) Urate levels ( 23263486)
Protein-Protein Interactions		8 interactors: ACVR1 ACVR1B ACVR2A ACVR2B HECTD1 IGF1 INHBB RANBP10	10 interactors: ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B FNTA IGSF1 INHA INHBA INHBC
Entrez ID		3547	3625
HPRD ID		02138	00934
Ensembl ID		ENSG00000147255	ENSG00000163083
Uniprot IDs		Q8N6C5	P09529
PDB IDs
Enriched GO Terms of Interacting Partners?		Activin Receptor Signaling Pathway Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Activin Receptor Signaling Pathway Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Positive Regulation Of Protein Phosphorylation Regulation Of Osteoblast Differentiation Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Positive Regulation Of Bone Mineralization Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Biomineral Tissue Development Regulation Of Ossification Positive Regulation Of Protein Metabolic Process Gastrulation With Mouth Forming Second Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Signal Transduction By Phosphorylation Developmental Process Involved In Reproduction Regulation Of Phosphorus Metabolic Process Regulation Of Bone Mineralization BMP Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Cell Differentiation Tissue Development Regulation Of Signaling Determination Of Left/right Symmetry Determination Of Bilateral Symmetry Tube Morphogenesis Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Epithelium Development Mesoderm Development Embryo Development Regulation Of Protein Metabolic Process Positive Regulation Of Erythrocyte Differentiation Reproductive Process Gastrulation Embryonic Morphogenesis System Development Positive Regulation Of Cellular Metabolic Process Tube Development Development Of Primary Sexual Characteristics Regulation Of Cell Differentiation Regulation Of Erythrocyte Differentiation	Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Signal Transduction By Phosphorylation Positive Regulation Of Erythrocyte Differentiation Regulation Of Signaling Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Mesoderm Development Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Erythrocyte Differentiation Positive Regulation Of Bone Mineralization Regulation Of Myeloid Cell Differentiation Signaling Positive Regulation Of Biomineral Tissue Development Cell Communication Gastrulation Negative Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Gastrulation With Mouth Forming Second Regulation Of Signal Transduction Regulation Of Follicle-stimulating Hormone Secretion SMAD Protein Signal Transduction Development Of Primary Sexual Characteristics Negative Regulation Of Hormone Secretion Hemoglobin Biosynthetic Process Cellular Response To Stimulus Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Gonadotropin Secretion Positive Regulation Of Myeloid Cell Differentiation BMP Signaling Pathway Sex Differentiation Negative Regulation Of B Cell Differentiation
Tagcloud ?		boys ch congenital definitive exome greatly harbored heterozygous hypothyroidism japanese lacks missense mothers nonsense prolactin q645x r1189x sequencing severely stature superfamily t3 t4 thereafter thrive traffic unexplained v1082e	actb activin activins canonical canonically comprise concert cord cords incompletely ligands maturation maturing morphogenetic myelin myelination numbers oligodendrocyte oligodendrocytes olp olps persistently recover smad3 smads specified spinal tgfbeta tgfbeta1
Tagcloud (Difference) ?		boys ch congenital definitive exome greatly harbored heterozygous hypothyroidism japanese lacks missense mothers nonsense prolactin q645x r1189x sequencing severely stature superfamily t3 t4 thereafter thrive traffic unexplained v1082e	actb activin activins canonical canonically comprise concert cord cords incompletely ligands maturation maturing morphogenetic myelin myelination numbers oligodendrocyte oligodendrocytes olp olps persistently recover smad3 smads specified spinal tgfbeta tgfbeta1
Tagcloud (Intersection) ?