IGSF1

Name	immunoglobulin superfamily member 1
Structure	No pdb structure
Interactors	8 interactors: ACVR1 ACVR1B ACVR2A ACVR2B HECTD1 IGF1 INHBB RANBP10
GO Annotations	Cellular Component	Extracellular Region Membrane
	Molecular Function	Protein Binding Inhibin Binding Activin Receptor Antagonist Activity
	Biological Process	Immune Response-regulating Signaling Pathway Regulation Of DNA-templated Transcription Negative Regulation Of Activin Receptor Signaling Pathway
GWAS	Age at voice drop ( 27182965 ) Menarche (age at onset) ( 27182965 )
Entrez ID	3547
HPRD ID	02138
Ensembl ID	ENSG00000147255
Uniprot IDs	Q8N6C5
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Activin Receptor Signaling Pathway Activin Receptor Complex Activin Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Activin Receptor Signaling Pathway Activin Receptor Activity Positive Regulation Of Activin Receptor Signaling Pathway Activin Receptor Activity, Type I Growth Factor Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Osteoblast Differentiation Gastrulation With Mouth Forming Second Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Ossification Regulation Of Osteoblast Differentiation Activin Receptor Activity, Type II Positive Regulation Of Bone Mineralization Negative Regulation Of Ossification Gastrulation Inhibin Binding Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Mesoderm Development Cellular Response To Growth Factor Stimulus Regulation Of Bone Mineralization BMP Receptor Activity Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Response To Growth Factor Determination Of Bilateral Symmetry Determination Of Left/right Symmetry Positive Regulation Of Signal Transduction Positive Regulation Of Cell Differentiation Protein Serine/threonine Kinase Activity Positive Regulation Of Multicellular Organismal Process Osteoblast Differentiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling System Development Protein Kinase Activity Cell Surface Receptor Signaling Pathway Regulation Of Reproductive Process Negative Regulation Of Multicellular Organismal Process Skeletal System Development Receptor Complex Endothelial Cell Differentiation Cellular Response To BMP Stimulus Kinase Activity