IGSF1 and HECTD1

Number of citations of the paper that reports this interaction (PMID 12421765)
28

Data Source:
HPRD (two hybrid)

		IGSF1	HECTD1
Gene Name		immunoglobulin superfamily, member 1	HECT domain containing E3 ubiquitin protein ligase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Membrane Integral Component Of Membrane	Nucleus Cytoplasm
	Molecular Function	Receptor Activity Protein Binding Coreceptor Activity Inhibin Binding	Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity Metal Ion Binding
	Biological Process	Regulation Of Transcription, DNA-templated Signal Transduction	Neural Tube Closure Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ACVR1 ACVR1B ACVR2A ACVR2B HECTD1 IGF1 INHBB RANBP10	2 interactors: IGSF1 YWHAG
Entrez ID		3547	25831
HPRD ID		02138	17098
Ensembl ID		ENSG00000147255	ENSG00000092148
Uniprot IDs		Q8N6C5	Q9ULT8
PDB IDs			2DK3 2LC3 3DKM
Enriched GO Terms of Interacting Partners?		Activin Receptor Signaling Pathway Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Activin Receptor Signaling Pathway Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Positive Regulation Of Protein Phosphorylation Regulation Of Osteoblast Differentiation Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Positive Regulation Of Bone Mineralization Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Biomineral Tissue Development Regulation Of Ossification Positive Regulation Of Protein Metabolic Process Gastrulation With Mouth Forming Second Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Signal Transduction By Phosphorylation Developmental Process Involved In Reproduction Regulation Of Phosphorus Metabolic Process Regulation Of Bone Mineralization BMP Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Cell Differentiation Tissue Development Regulation Of Signaling Determination Of Left/right Symmetry Determination Of Bilateral Symmetry Tube Morphogenesis Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Epithelium Development Mesoderm Development Embryo Development Regulation Of Protein Metabolic Process Positive Regulation Of Erythrocyte Differentiation Reproductive Process Gastrulation Embryonic Morphogenesis System Development Positive Regulation Of Cellular Metabolic Process Tube Development Development Of Primary Sexual Characteristics Regulation Of Cell Differentiation Regulation Of Erythrocyte Differentiation
Tagcloud ?		boys ch congenital definitive exome greatly harbored heterozygous hypothyroidism japanese lacks missense mothers nonsense prolactin q645x r1189x sequencing severely stature superfamily t3 t4 thereafter thrive traffic unexplained v1082e	adenomatous apc augmented axin chains ck1alpha confers conjugated destruction diminished disrupted e3 earmarking effector foster gsk3beta ligase lys modifies polyposis polyubiquitin polyubiquitylation promotes proteasomal stabilization ubiquitin ubiquitylation wnt wnt3a
Tagcloud (Difference) ?		boys ch congenital definitive exome greatly harbored heterozygous hypothyroidism japanese lacks missense mothers nonsense prolactin q645x r1189x sequencing severely stature superfamily t3 t4 thereafter thrive traffic unexplained v1082e	adenomatous apc augmented axin chains ck1alpha confers conjugated destruction diminished disrupted e3 earmarking effector foster gsk3beta ligase lys modifies polyposis polyubiquitin polyubiquitylation promotes proteasomal stabilization ubiquitin ubiquitylation wnt wnt3a
Tagcloud (Intersection) ?