COG7 and TAX1BP1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid, two hybrid)

		COG7	TAX1BP1
Name		component of oligomeric golgi complex 7	Tax1 binding protein 1
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleolus Golgi Apparatus Membrane Golgi Transport Complex Trans-Golgi Network Membrane	Phagophore Assembly Site Cytoplasm Mitochondrion Autophagosome Cytosol Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	Protein Binding	Protein Binding Zinc Ion Binding Kinase Binding Protein-macromolecule Adaptor Activity Signaling Adaptor Activity Metal Ion Binding
	Biological Process	Retrograde Transport, Vesicle Recycling Within Golgi Protein Glycosylation Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Golgi Organization Protein Transport Protein Localization To Organelle Protein Localization To Golgi Apparatus Protein Stabilization Glycosylation	Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Autophagy Apoptotic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Protein K48-linked Ubiquitination Protein Localization To Phagocytic Vesicle Negative Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways		COPI-mediated anterograde transport Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network	Regulation of TNFR1 signaling Negative regulators of DDX58/IFIH1 signaling
Diseases		Congenital disorders of glycosylation (CDG) type II	None
GWAS		Egg allergy ( 25710614 )	Adventurousness ( 30643258 ) Alcoholic chronic pancreatitis ( 28754779 ) Allergic rhinitis ( 30013184 ) Asthma ( 31959851 ) Asthma (childhood onset) ( 31036433 ) Hypospadias ( 25108383 ) Metabolite levels ( 23823483 )
Novel Interactors		2 novel interactors: DCTN5 NFKBIE	1 novel interactors: SERPINB7
Interacting Genes		8 interacting genes: COG4 COG5 EMILIN1 HNRNPD KIFC3 MEOX2 TAX1BP1 ZNF471	72 interacting genes: ARHGAP1 ARK2N AZI2 CBX8 COG7 CWF19L2 CXXC1 DAXX DAZAP2 DSTN ENTREP1 FAM161A FAM168A FAM90A1 FOXC2 GABARAP GABARAPL1 GABARAPL2 IGFN1 IKBKG KANK2 KAT5 KIF5B L3MBTL2 LITAF LMO3 LNX1 LRATD2 MAP1LC3C MRPL11 MRPL53 MYO6 NMRK1 NTAQ1 ORC5 PIBF1 PLEKHB2 PLEKHN1 POLR1C RAB18 RAD18 RAD23B RAD54L2 RIPK1 RNF11 RNF26 SCNM1 SH3GLB1 SSX2 STARD13 TBC1D15 TBC1D17 TCAF1 TCEA2 TCL1A TNFAIP3 TNIP3 TRAF4 TRAF6 TRAPPC6A TRIM14 TRIM45 TSEN2 TSG101 TSHZ3 UBA52 UBASH3A UBB UBC UBTFL1 USP2 ZNF446
Entrez ID		91949	8887
HPRD ID		07373	05618
Ensembl ID		ENSG00000168434	ENSG00000106052
Uniprot IDs		A0A0S2Z652 P83436	B4DSG5 Q86VP1
PDB IDs		Not available	2M7Q 4BMJ 4NLH 4Z4K 4Z4M 5AAS 5YT6 5Z7G 8W6A 8W6B
GO Terms Enriched among Interactors		Golgi Transport Complex Retrograde Transport, Vesicle Recycling Within Golgi Golgi Organization Intra-Golgi Vesicle-mediated Transport Hepatocyte Dedifferentiation Cellular Response To Putrescine	Ubiquitin Protein Ligase Binding Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Protein Binding Autophagosome Autophagosome Maturation Protein-containing Complex Disassembly Autophagosome Membrane Cytoplasm Modification-dependent Protein Catabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Polyubiquitin Modification-dependent Protein Binding Macromolecule Catabolic Process Endosome Membrane Proteolysis Involved In Protein Catabolic Process Protein Tag Activity Autophagy GABA Receptor Binding Autophagosome Assembly Regulation Of Canonical NF-kappaB Signal Transduction Macroautophagy Autophagosome Organization Mitophagy Ubiquitin Protein Ligase Activity Cellular Response To Starvation WW Domain Binding Post-translational Protein Modification Protein Ubiquitination Autophagy Of Mitochondrion Catabolic Process Regulation Of Protein Modification Process Signaling Adaptor Activity Response To Starvation Protein Modification Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Beta-tubulin Binding Regulation Of Primary Metabolic Process Cellular Response To Nutrient Levels Organelle Assembly Vacuole Organization Identical Protein Binding Zinc Ion Binding Cytosol Positive Regulation Of Protein Modification Process