COG7 and NFKBIE

Data Source: HiPPIP (Novel)

		COG7	NFKBIE
Name		component of oligomeric golgi complex 7	NFKB inhibitor epsilon
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleolus Golgi Apparatus Membrane Golgi Transport Complex Trans-Golgi Network Membrane	Fibrillar Center Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding	Protein Binding Protein Sequestering Activity
	Biological Process	Retrograde Transport, Vesicle Recycling Within Golgi Protein Glycosylation Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Golgi Organization Protein Transport Protein Localization To Organelle Protein Localization To Golgi Apparatus Protein Stabilization Glycosylation	None
Pathways		COPI-mediated anterograde transport Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network	Activation of NF-kappaB in B cells
Diseases		Congenital disorders of glycosylation (CDG) type II	Hodgkin lymphoma
GWAS		Egg allergy ( 25710614 )	Monocyte count ( 27863252 32888494 ) Monocyte percentage of white cells ( 27863252 32888494 ) Rheumatoid arthritis ( 22446963 23028356 24390342 30423114 32723749 )
Novel Interactors		2 novel interactors: DCTN5 NFKBIE	6 novel interactors: BYSL COG7 GUCA1B NPR3 PEX6 POLH
Interacting Genes		8 interacting genes: COG4 COG5 EMILIN1 HNRNPD KIFC3 MEOX2 TAX1BP1 ZNF471	15 interacting genes: ANKHD1 C1QBP CUL1 HDAC4 HDAC5 IL1A JUP KBTBD7 NCOR2 NFKB1 NFKB2 PPP6C REL RELA SKP1
Entrez ID		91949	4794
HPRD ID		07373	05181
Ensembl ID		ENSG00000168434	ENSG00000146232
Uniprot IDs		A0A0S2Z652 P83436	O00221 Q7LC14 Q96F31
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Golgi Transport Complex Retrograde Transport, Vesicle Recycling Within Golgi Golgi Organization Intra-Golgi Vesicle-mediated Transport Hepatocyte Dedifferentiation Cellular Response To Putrescine	Non-canonical NF-kappaB Signal Transduction Defense Response Response To External Biotic Stimulus NF-kappaB P50/p65 Complex Canonical NF-kappaB Signal Transduction Immune System Process I-kappaB/NF-kappaB Complex Immune Response Innate Immune Response NF-kappaB Complex Histone Deacetylase Binding Defense Response To Symbiont Defense Response To Other Organism Response To Lipopolysaccharide Cytosol Inflammatory Response Response To Molecule Of Bacterial Origin Cellular Response To Nicotine Ubiquitin Ligase Complex Scaffold Activity Cellular Response To Lipopolysaccharide Regulation Of Interleukin-12 Production Histone Deacetylase Activity, Hydrolytic Mechanism Positive Regulation Of Transcription By RNA Polymerase II Response To Stress Cellular Response To Molecule Of Bacterial Origin Protein Lysine Deacetylase Activity Actinin Binding Nucleoplasm Tissue Remodeling Positive Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Angiotensin Regulation Of MiRNA Metabolic Process Cellular Response To Interleukin-6 Negative Regulation Of Interleukin-12 Production Negative Regulation Of Myotube Differentiation Response To Other Organism Histone Deacetylase Activity Transcription Cis-regulatory Region Binding Response To Interleukin-6 Regulation Of Transcription By RNA Polymerase II Response To Lipid Protein K48-linked Ubiquitination Nucleus Regulation Of Signal Transduction Positive Regulation Of Epithelial Cell Apoptotic Process Regulation Of Protein Sumoylation DNA-binding Transcription Activator Activity Response To Angiotensin Response To Cytokine Response To Muscle Stretch