TFRC and HFE

Number of citations of the paper that reports this interaction (PubMedID 9465039)
29

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		TFRC	HFE
Description		transferrin receptor	homeostatic iron regulator
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endosome Early Endosome Plasma Membrane Clathrin-coated Pit External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane Basolateral Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Melanosome Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Blood Microparticle Postsynapse Postsynaptic Recycling Endosome Membrane Glutamatergic Synapse Extracellular Vesicle HFE-transferrin Receptor Complex	Extracellular Space Nucleoplasm Early Endosome Plasma Membrane External Side Of Plasma Membrane Membrane Cytoplasmic Vesicle MHC Class I Protein Complex Apical Part Of Cell Basal Part Of Cell Perinuclear Region Of Cytoplasm Recycling Endosome HFE-transferrin Receptor Complex
	Molecular Function	Virus Receptor Activity RNA Binding Double-stranded RNA Binding Transferrin Receptor Activity Protein Binding Protein Kinase Binding Hsp70 Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Protein-folding Chaperone Binding	Signaling Receptor Binding Protein Binding Beta-2-microglobulin Binding Co-receptor Binding Peptide Antigen Binding Transporter Activator Activity Transferrin Receptor Binding
	Biological Process	Regulation Of Cell Growth Response To Hypoxia Iron Ion Transport Intracellular Iron Ion Homeostasis Endocytosis Receptor-mediated Endocytosis Acute-phase Response Signal Transduction Cell Surface Receptor Signaling Pathway Response To Nutrient Response To Iron Ion Response To Manganese Ion Positive Regulation Of Gene Expression Negative Regulation Of Mitochondrial Fusion Osteoclast Differentiation Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein-containing Complex Assembly Receptor Internalization Response To Retinoic Acid Transferrin Transport Intracellular Signal Transduction Positive Regulation Of T Cell Proliferation Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Isotype Switching Response To Copper Ion Symbiont Entry Into Host Cell Multicellular Organismal-level Iron Ion Homeostasis Cellular Response To Xenobiotic Stimulus Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Transport Across Blood-brain Barrier Positive Regulation Of Protein Localization To Nucleus Cellular Response To Leukemia Inhibitory Factor	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of T Cell Mediated Immunity Negative Regulation Of T Cell Cytokine Production Monoatomic Ion Transport Iron Ion Transport Intracellular Iron Ion Homeostasis Receptor-mediated Endocytosis Cell Surface Receptor Signaling Pathway Response To Iron Ion Positive Regulation Of Gene Expression Antigen Processing And Presentation BMP Signaling Pathway Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Transferrin Transport Regulation Of Iron Ion Transport Hormone Biosynthetic Process Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of SMAD Protein Signal Transduction Multicellular Organismal-level Iron Ion Homeostasis Protein-containing Complex Assembly Cellular Response To Iron Ion Positive Regulation Of Peptide Hormone Secretion Negative Regulation Of Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Response To Iron Ion Starvation Regulation Of Protein Localization To Cell Surface Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation
Pathways		Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle Transferrin endocytosis and recycling RND2 GTPase cycle RND1 GTPase cycle Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	Transferrin endocytosis and recycling
Drugs		Iron Ferrous sulfate anhydrous Ferric cation Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate Tetraferric tricitrate decahydrate Ferric derisomaltose
Diseases			Hemochromatosis (HFE); Juvenile hemochromatosis (JH)
GWAS		Asthma ( 31959851 30929738) Asthma (adult onset) ( 30929738) Heel bone mineral density x serum urate levels interaction ( 34046847) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Iron status biomarkers (total iron binding capacity) ( 33536631) Iron status biomarkers (transferrin levels) ( 25352340) Iron status biomarkers (transferrin saturation) ( 25352340 33536631) Mean corpuscular hemoglobin ( 19862010 20139978 32888494 28453575 27863252) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 32888494 19862010 20139978 28453575 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neurofibrillary tangles ( 31497858) Pancreatic cancer ( 22158540) Red blood cell traits ( 23222517) Red cell distribution width ( 28957414 32888494 27863252) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Type 2 diabetes ( 32499647)	Alanine aminotransferase levels ( 34315874) Alcohol consumption (transferrin glycosylation) ( 21665994) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 34315874) Autism spectrum disorder or schizophrenia ( 28540026) Blood pressure ( 21909110) Brain morphology (MOSTest) ( 32665545) Cardiovascular disease risk factors ( 21943158) Cholesterol, total ( 20686565 24097068) Diastolic blood pressure ( 21909115 27618447 27618452 27841878 28739976) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Estimated glomerular filtration rate in non-diabetics ( 31451708) Feeling guilty ( 29500382) Fish- and plant-related diet ( 32066663) Glycated hemoglobin levels ( 20858683 28898252 34059833) HDL cholesterol levels ( 32203549) Hematocrit ( 19862010 27863252 28017375 32888494) Hematological parameters ( 19820697) Hematology traits ( 23263863) Hemoglobin ( 19820698 19862010 28453575 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 28017375 32327693) Hepcidin levels ( 21785125) Hepcidin/ferritin ratio ( 27846281) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Hip circumference adjusted for BMI ( 34021172) Hypertension ( 21909115) Intelligence (MTAG) ( 29326435) Iron status biomarkers ( 19084217 19820699 21149283 21208937 21483845 25224454) Iron status biomarkers (ferritin levels) ( 25352340 28334935 33536631) Iron status biomarkers (iron levels) ( 25352340 28334935 33536631) Iron status biomarkers (total iron binding capacity) ( 28334935 33536631) Iron status biomarkers (transferrin levels) ( 25352340) Iron status biomarkers (transferrin saturation) ( 25352340 28334935 33536631) LDL cholesterol ( 20686565 24097068) LDL cholesterol levels ( 32203549) Liver fibrosis and steatohepatitis severity (MRI cT1 measure) ( 32247823) Liver iron content ( 34128465) Low density lipoprotein cholesterol levels ( 32154731) Mean arterial pressure ( 27618448) Mean corpuscular hemoglobin ( 19853236 23263863 28017375 28453575 29403010 32888494) Mean corpuscular hemoglobin concentration ( 27863252 28017375 29403010 32888494) Mean corpuscular volume ( 19862010 20139978 28017375 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Number of sexual partners ( 30643258) Osteoarthritis (hip) ( 30374069) Platelet count ( 27863252 32888494) Red blood cell count ( 27863252 32888494) Red blood cell traits ( 20927387 23222517 23446634) Red cell distribution width ( 28957414 32888494) Refractive error ( 32231278) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Schizophrenia ( 30285260) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 21909115 27618452 27841878 28739976) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Worry too long after an embarrassing experience ( 29500382)
Interacting Genes		35 interacting genes: ACAP1 AQP6 ARL13B ASGR2 B4GALT1 C1orf159 CD247 CD4 CREB3L1 FAM209A FAM210B GABARAP GET1 GPR152 GRM2 HFE HIBADH LHFPL5 LMNA MFF MGST3 PAGE1 PINX1 RAB5B RAB8A RANBP9 RASSF3 RELL2 RMDN3 SGTA SLC10A1 SLC18A1 SNCA TF TINF2	4 interacting genes: B2M SNCA TFR2 TFRC
Entrez ID		7037	3077
HPRD ID		01812	01993
Ensembl ID		ENSG00000072274	ENSG00000010704
Uniprot IDs		A0A8V8TM46 A8K6Q8 B7Z2I6 G3V0E5 P02786	B4DV50 F8W7W8 H7C4K4 Q30201 Q6B0J5
PDB IDs		1CX8 1DE4 1SUV 2NSU 3KAS 3S9L 3S9M 3S9N 6D03 6D04 6D05 6GSR 6H5I 6OKD 6W3H 6WRV 6WRW 6WRX 6Y76 7ZQS 8P0Z	1A6Z 1DE4
Enriched GO Terms of Interacting Partners?		Membrane Protein Tyrosine Kinase Binding Beta-tubulin Binding Response To Iron Ion Mitochondrial Outer Membrane HFE-transferrin Receptor Complex Cellular Response To Iron Ion Transferrin Receptor Binding Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Catecholamine Uptake Dopamine Uptake Protein Localization To Chromosome, Telomeric Region Regulation Of Ubiquitin-dependent Protein Catabolic Process Basal Part Of Cell Tail-anchored Membrane Protein Insertion Into ER Membrane T Cell Receptor Complex Regulation Of Glutamate Secretion Establishment Of Protein Localization Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Stability Protein Targeting Neurotransmitter Reuptake Dopamine Transport Ferrous Iron Binding Negative Regulation Of Telomere Maintenance Via Telomerase Cytoplasmic Vesicle Nitrate Transmembrane Transporter Activity Plasma Membrane Interleukin-16 Binding Interleukin-16 Receptor Activity Helper T Cell Enhancement Of Adaptive Immune Response Positive Regulation Of Circulating Fibrinogen Levels Secretory Granule Membrane Regulation Of Dopamine Secretion Multicellular Organismal-level Iron Ion Homeostasis Negative Regulation Of Protein Catabolic Process Negative Regulation Of Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Regulation Of Telomere Maintenance Non-motile Cilium Regulation Of Long-term Neuronal Synaptic Plasticity Protein Insertion Into ER Membrane Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Targeting To ER Positive Regulation Of Proteasomal Protein Catabolic Process Monoamine Transport Neurotransmitter Uptake Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity	Response To Iron Ion HFE-transferrin Receptor Complex Transferrin Transport Multicellular Organismal-level Iron Ion Homeostasis Transferrin Receptor Activity Iron Ion Transport Response To Metal Ion Intracellular Iron Ion Homeostasis Multicellular Organismal-level Chemical Homeostasis Inorganic Ion Homeostasis Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Cellular Response To Iron Ion Positive Regulation Of Endocytosis Cellular Response To Metal Ion Receptor-mediated Endocytosis Chemical Homeostasis Amyloid Fibril Formation Positive Regulation Of Cellular Component Organization Regulation Of Endocytosis Response To Copper Ion Homeostatic Process External Side Of Plasma Membrane Hsp70 Protein Binding Intracellular Monoatomic Ion Homeostasis Intracellular Monoatomic Cation Homeostasis Endocytosis Multicellular Organismal-level Homeostasis Receptor Internalization Intracellular Chemical Homeostasis Regulation Of Vesicle-mediated Transport Metal Ion Transport Protein Tetramerization Import Into Cell Cellular Homeostasis Recycling Endosome Membrane Regulation Of Cell Activation Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Endocytic Iron Import Into Cell Negative Regulation Of Cellular Component Organization Monoatomic Cation Transport Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response Response To Lipid Cellular Response To Iron(III) Ion
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