TFRC and AQP6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TFRC	AQP6
Description		transferrin receptor	aquaporin 6
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endosome Early Endosome Plasma Membrane Clathrin-coated Pit External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane Basolateral Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Melanosome Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Blood Microparticle Postsynapse Postsynaptic Recycling Endosome Membrane Glutamatergic Synapse Extracellular Vesicle HFE-transferrin Receptor Complex	Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	Virus Receptor Activity RNA Binding Double-stranded RNA Binding Transferrin Receptor Activity Protein Binding Protein Kinase Binding Hsp70 Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Protein-folding Chaperone Binding	Monoatomic Anion Channel Activity Protein Binding Ammonium Channel Activity Nitrate Transmembrane Transporter Activity Water Channel Activity Channel Activity Carbon Dioxide Transmembrane Transporter Activity PH-gated Chloride Channel Activity
	Biological Process	Regulation Of Cell Growth Response To Hypoxia Iron Ion Transport Intracellular Iron Ion Homeostasis Endocytosis Receptor-mediated Endocytosis Acute-phase Response Signal Transduction Cell Surface Receptor Signaling Pathway Response To Nutrient Response To Iron Ion Response To Manganese Ion Positive Regulation Of Gene Expression Negative Regulation Of Mitochondrial Fusion Osteoclast Differentiation Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein-containing Complex Assembly Receptor Internalization Response To Retinoic Acid Transferrin Transport Intracellular Signal Transduction Positive Regulation Of T Cell Proliferation Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Isotype Switching Response To Copper Ion Symbiont Entry Into Host Cell Multicellular Organismal-level Iron Ion Homeostasis Cellular Response To Xenobiotic Stimulus Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Transport Across Blood-brain Barrier Positive Regulation Of Protein Localization To Nucleus Cellular Response To Leukemia Inhibitory Factor	Renal Water Transport Carbon Dioxide Transport Nitrate Transmembrane Transport Carbon Dioxide Transmembrane Transport Odontogenesis Transmembrane Transport Ammonium Transmembrane Transport Monoatomic Anion Transmembrane Transport Chloride Transmembrane Transport
Pathways		Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle Transferrin endocytosis and recycling RND2 GTPase cycle RND1 GTPase cycle Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	Passive transport by Aquaporins
Drugs		Iron Ferrous sulfate anhydrous Ferric cation Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate Tetraferric tricitrate decahydrate Ferric derisomaltose
Diseases
GWAS		Asthma ( 31959851 30929738) Asthma (adult onset) ( 30929738) Heel bone mineral density x serum urate levels interaction ( 34046847) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Iron status biomarkers (total iron binding capacity) ( 33536631) Iron status biomarkers (transferrin levels) ( 25352340) Iron status biomarkers (transferrin saturation) ( 25352340 33536631) Mean corpuscular hemoglobin ( 19862010 20139978 32888494 28453575 27863252) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 32888494 19862010 20139978 28453575 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neurofibrillary tangles ( 31497858) Pancreatic cancer ( 22158540) Red blood cell traits ( 23222517) Red cell distribution width ( 28957414 32888494 27863252) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Type 2 diabetes ( 32499647)
Interacting Genes		35 interacting genes: ACAP1 AQP6 ARL13B ASGR2 B4GALT1 C1orf159 CD247 CD4 CREB3L1 FAM209A FAM210B GABARAP GET1 GPR152 GRM2 HFE HIBADH LHFPL5 LMNA MFF MGST3 PAGE1 PINX1 RAB5B RAB8A RANBP9 RASSF3 RELL2 RMDN3 SGTA SLC10A1 SLC18A1 SNCA TF TINF2	327 interacting genes: ABCG1 ABHD16A ACSL5 ADGRE2 ADIPOQ AGMO AGPAT3 AGPAT4 AGTRAP AIG1 ALOX5AP ANKRD46 AOC2 APOA2 APOL3 AQP1 ARL6IP1 ARL6IP6 ARLN ARV1 ATP13A1 ATP6V0C BET1 BMP10 BRICD5 BSG BTN2A2 C14orf180 C1GALT1 C2CD2L C3orf52 C5 C5orf46 CATSPERH CCDC167 CCL22 CCL4L2 CD52 CD68 CD81 CDIPT CGREF1 CLDN19 CLDN4 CLDND2 CMTM3 CMTM5 CMTM7 CNIH1 CNIH3 CORIN COX20 CTSA CTXN3 CXCL16 CXCL9 CXorf66 CYB561 CYB561A3 CYB561D1 CYB5B CYB5R3 CYBC1 CYP4F2 CYP4F22 DEFB103A DEFB103B DEFB108B DEFB127 DERL1 DGAT2L6 DHRSX DNAJC30 EBP EFNA5 EMC6 EMD EMP1 EMP3 ERG28 ERMP1 FA2H FAM177A1 FAXDC2 FDFT1 FIS1 FKBP8 FUNDC2 FXYD3 FXYD6 FXYD6-FXYD2 GAST GIMAP1 GIMAP5 GJB2 GKN1 GOLT1A GOSR2 GPR151 GPR152 GPR25 GRM2 GYPC HMOX1 HMOX2 HSD3B1 HTATIP2 ICMT IFITM3 IFNGR1 IGFBP5 INSIG1 INSIG2 ITGAM JAGN1 JPH1 KCNK1 LEMD1 LEPROT LHFPL5 LNPEP LPAR3 LSS LY6D MAL MAL2 MALL MARCHF2 MARCHF5 MFF MGAM MGLL MIP MMP14 MS4A1 MS4A13 MYADML2 NAT8 NEU1 NINJ1 NINJ2 NKG7 NRM ORMDL1 ORMDL2 ORMDL3 OTULINL PAEP PDZK1IP1 PEDS1-UBE2V1 PEMT PEX11G PEX16 PIGF PLLP PLN PLP1 PLP2 PLPP6 PMP22 PRAF2 PRB1 PRH1 PRRT2 PTPN1 PTPN9 RAB18 RABAC1 REEP6 RFT1 RHD RPRM RTP2 RUSF1 SACM1L SCAMP4 SCAMP5 SCD SCGB1A1 SEC22A SEC22B SEC61G SELENOK SERF1A SERF1B SERP1 SERP2 SFRP4 SFT2D1 SFT2D2 SFXN1 SFXN2 SFXN3 SFXN5 SLC16A12 SLC16A13 SLC25A46 SLC30A2 SLC30A3 SLC30A8 SLC33A2 SLC35A1 SLC35B1 SLC35B2 SLC35B4 SLC35E4 SLC35F1 SLC35F6 SLC35G2 SLC38A1 SLC38A7 SLC39A2 SLC39A7 SLC39A9 SLC41A1 SLC41A2 SLC52A1 SLC61A1 SLC66A1 SLC66A2 SLC7A1 SLC7A8 SLCO3A1 SMAGP SMCO4 SMIM1 SNORC ST6GAL2 STARD3 STATH STRIT1 STX12 STX1B STX3 STX5 STX6 STX7 STX8 SYNDIG1 SYNGR1 SYNJ2BP TAP1 TBC1D20 TECR TFRC THBD THSD7A THSD7B TIMM23 TLCD1 TMEM100 TMEM107 TMEM11 TMEM115 TMEM119 TMEM120A TMEM120B TMEM128 TMEM140 TMEM143 TMEM144 TMEM14A TMEM14C TMEM167B TMEM19 TMEM203 TMEM218 TMEM222 TMEM229B TMEM234 TMEM239 TMEM242 TMEM243 TMEM254 TMEM42 TMEM50A TMEM51 TMEM60 TMEM65 TMEM69 TMEM74 TMEM86B TMEM97 TMIE TMUB2 TMX2 TNFRSF10C TOMM22 TOMM6 TPRG1 TREX1 TSNARE1 TSPO2 UBE2J1 UBE2J2 UBIAD1 UBTD2 UBXN8 UNC50 UNC93A UNC93B1 USE1 VAMP1 VAMP2 VAMP3 VAMP4 VAMP5 VAPA VAPB VEZT VKORC1L1 VMA12 VMA21 VRK2 VSTM1 VTI1B WFS1 XKR3 YIF1A YIPF1 YIPF2 YIPF4 YIPF6 ZDHHC21 ZDHHC24 ZFPL1 ZNF587
Entrez ID		7037	363
HPRD ID		01812	03226
Ensembl ID		ENSG00000072274	ENSG00000086159
Uniprot IDs		A0A8V8TM46 A8K6Q8 B7Z2I6 G3V0E5 P02786	Q13520
PDB IDs		1CX8 1DE4 1SUV 2NSU 3KAS 3S9L 3S9M 3S9N 6D03 6D04 6D05 6GSR 6H5I 6OKD 6W3H 6WRV 6WRW 6WRX 6Y76 7ZQS 8P0Z
Enriched GO Terms of Interacting Partners?		Membrane Protein Tyrosine Kinase Binding Beta-tubulin Binding Response To Iron Ion Mitochondrial Outer Membrane HFE-transferrin Receptor Complex Cellular Response To Iron Ion Transferrin Receptor Binding Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Catecholamine Uptake Dopamine Uptake Protein Localization To Chromosome, Telomeric Region Regulation Of Ubiquitin-dependent Protein Catabolic Process Basal Part Of Cell Tail-anchored Membrane Protein Insertion Into ER Membrane T Cell Receptor Complex Regulation Of Glutamate Secretion Establishment Of Protein Localization Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Stability Protein Targeting Neurotransmitter Reuptake Dopamine Transport Ferrous Iron Binding Negative Regulation Of Telomere Maintenance Via Telomerase Cytoplasmic Vesicle Nitrate Transmembrane Transporter Activity Plasma Membrane Interleukin-16 Binding Interleukin-16 Receptor Activity Helper T Cell Enhancement Of Adaptive Immune Response Positive Regulation Of Circulating Fibrinogen Levels Secretory Granule Membrane Regulation Of Dopamine Secretion Multicellular Organismal-level Iron Ion Homeostasis Negative Regulation Of Protein Catabolic Process Negative Regulation Of Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Regulation Of Telomere Maintenance Non-motile Cilium Regulation Of Long-term Neuronal Synaptic Plasticity Protein Insertion Into ER Membrane Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Targeting To ER Positive Regulation Of Proteasomal Protein Catabolic Process Monoamine Transport Neurotransmitter Uptake Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding SNAP Receptor Activity SNARE Complex Endomembrane System Membrane Organization Membrane Fusion Vesicle Fusion Organelle Membrane Fusion Cellular Localization Establishment Of Protein Localization Organelle Fusion Golgi Membrane Lipid Biosynthetic Process Transmembrane Transport Sterol Biosynthetic Process Membrane Docking Organelle Localization By Membrane Tethering SNARE Binding Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Vesicle-mediated Transport Steroid Biosynthetic Process Intracellular Transport Plasma Membrane Vesicle Organization Vesicle Docking Synaptic Vesicle Membrane Cholesterol Biosynthetic Process Golgi Vesicle Transport Amino Acid Transport Structural Constituent Of Myelin Sheath Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Sterol Metabolic Process Chemical Homeostasis Monoatomic Ion Transmembrane Transporter Activity Establishment Of Localization In Cell Mitochondrial Outer Membrane Organic Anion Transport Zinc Ion Transmembrane Transporter Activity Mitochondrial Transport Amino Acid Transmembrane Transport Serine Import Into Mitochondrion Cytoplasmic Vesicle Zinc Ion Transmembrane Transport Transmembrane Transporter Activity Zinc Ion Transport Establishment Of Protein Localization To Membrane
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