FIBP and PKNOX1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		FIBP	PKNOX1
Description		FGF1 intracellular binding protein	PBX/knotted 1 homeobox 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Endomembrane System Membrane Nuclear Speck	Chromatin Nucleus Transcription Regulator Complex Cytoplasm
	Molecular Function	Fibroblast Growth Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Fibroblast Growth Factor Receptor Signaling Pathway Platelet Aggregation	Angiogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Hemopoiesis T Cell Differentiation Erythrocyte Differentiation Camera-type Eye Development Positive Regulation Of Transcription By RNA Polymerase II
Pathways			Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Asthma ( 31959851) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Psoriasis ( 28537254)	Biochemical measures ( 19260141) Blood and toenail selenium levels ( 25343990) Cognitive performance ( 20125193) Information processing speed ( 21130836)
Interacting Genes		10 interacting genes: APP CSNK2A1 CSNK2B DAPK1 FGF1 FGFBP1 GSK3B PKNOX1 RNF32 TENM1	56 interacting genes: ANKRD49 APC APP ARL13B BAIAP2 BEX4 BLOC1S5 BORCS6 BRD2 C1S CAPRIN1 CMYA5 EEF1A2 EXOC7 FAM110B FHL2 FIBP FMNL2 GAS7 HMGB2 HOXA1 HOXB6 HOXB7 HOXD9 ITGB3BP KIF1A KIF1B MACF1 MEIS1 MPP3 NRIP1 NUP58 PAX6 PBX1 PBX2 PBX3 PFDN2 POU2F1 PRSS3 RAB11FIP4 RFX3 RNF40 SPTBN1 STAT1 STAT6 SYNM TCOF1 TEKT4P2 TET2 TLX1 TRIM59 TTC3 UBR1 VPS37C WIZ ZBTB3
Entrez ID		9158	5316
HPRD ID		08492	03653
Ensembl ID		ENSG00000172500	ENSG00000160199
Uniprot IDs		O43427	B4DGV5 E7EPN6 P55347 Q6PKH2 Q96I87
PDB IDs			1X2N
Enriched GO Terms of Interacting Partners?		Heparin Binding Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Proteolysis Regulation Of Translation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Protein Serine/threonine Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell Migration Regulation Of Cell Population Proliferation PcG Protein Complex Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Autophagy Regulation Of Cell Motility Regulation Of Endothelial Cell Migration Regulation Of Locomotion Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process Positive Regulation Of Cell Migration Positive Regulation Of MAP Kinase Activity Positive Regulation Of Protein Catabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Motility Negative Regulation Of Protein Metabolic Process Neuron Projection Organization Post-transcriptional Regulation Of Gene Expression Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Locomotion Negative Regulation Of Protein Localization To Nucleus Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Transport Cellular Response To Amyloid-beta Signal Transduction Wnt Signaling Pathway Negative Regulation Of Cell Population Proliferation	Pattern Specification Process Positive Regulation Of Transcription By RNA Polymerase II Chromatin DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Regionalization Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Embryonic Morphogenesis Regulation Of RNA Metabolic Process Microtubule Anatomical Structure Morphogenesis Anterior/posterior Pattern Specification Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Animal Organ Morphogenesis Eye Development Regulation Of Nucleobase-containing Compound Metabolic Process Microtubule-based Transport Nucleus Proximal/distal Pattern Formation Retrograde Neuronal Dense Core Vesicle Transport DNA Binding Axo-dendritic Transport Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Organelle Transport Along Microtubule Transport Along Microtubule Positive Regulation Of Biosynthetic Process Neuron Development Sensory Organ Development Positive Regulation Of Macromolecule Metabolic Process Regulation Of Dendritic Spine Morphogenesis Dense Core Granule Cytoskeletal Transport Transcription Coregulator Binding Anterograde Axonal Transport Regulation Of Metabolic Process Vesicle Transport Along Microtubule Positive Regulation Of Metabolic Process Cytoskeleton-dependent Intracellular Transport Regulation Of Gene Expression Transcription Corepressor Binding
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