EXOC8 and MARCHF7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EXOC8	MARCHF7
Description		exocyst complex component 8	membrane associated ring-CH-type finger 7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Exocyst Cytoplasm Late Endosome Cytosol Plasma Membrane Membrane Growth Cone Cell Projection Perinuclear Region Of Cytoplasm Cell Periphery	Nucleus Cytoplasm Centrosome Cytosol Plasma Membrane Ciliary Basal Body
	Molecular Function	Protein Binding Small GTPase Binding Phosphatidylinositol Binding	Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity MDM2/MDM4 Family Protein Binding
	Biological Process	Mitotic Cytokinesis Exocytosis Golgi To Plasma Membrane Transport Vesicle Docking Involved In Exocytosis Endosome Organization Intracellular Protein Localization Protein Transport Regulation Of Macroautophagy Extracellular Matrix Disassembly Membrane Fission Vesicle Tethering Involved In Exocytosis	Regulation Of Tolerance Induction Protein Monoubiquitination Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Negative Regulation Of T Cell Proliferation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Stabilization Protein Autoubiquitination Cilium Assembly Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Cilium Assembly Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Protein Polyubiquitination Negative Regulation Of Protein Autoubiquitination
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium
Drugs
Diseases
GWAS		Hemoglobin concentration ( 27863252)	Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		88 interacting genes: AIMP2 ANKRD36B ATP23 BEX2 BICRAL BLOC1S2 BLOC1S6 BLZF1 BORCS6 CAPN3 CCDC33 CCDC85B CCHCR1 CDSN CEP57L1 CWF19L2 DMAP1 EFHC2 ELL2 ESS2 EXOC2 FAM217B GOLGA2 GRAMD4 GTF2E2 HGS IHO1 IKZF3 ISY1 ISY1-RAB43 KIAA1217 KIFC3 KRT15 KRT18 KRT19 KRT20 KRT31 KRT34 KRT36 KRT76 LNX1 LZTS1 MARCHF7 MBD3L1 MBIP MIPOL1 MTUS2 MYOZ3 NAB2 NDC80 NUP54 PBX4 PCM1 PRR35 RAB3IL1 RALA RAPGEF3 RINT1 RUSC1 SASH1 SCARA5 SNAPC1 STMN3 SYCE1 SYT17 TADA2A TBC1D22B TCF12 TCF4 TFIP11 TRIM14 TRIM21 TRIM27 TRIM54 ULK1 UQCC2 USHBP1 USP54 VPS16 VPS37B WASHC1 ZC2HC1A ZNF177 ZNF35 ZNF559-ZNF177 ZNF566 ZNF628 ZSCAN4	22 interacting genes: ATG14 CTNNA3 EXOC8 HSF2BP IQCB1 MAPRE1 MAPRE3 MAPT NLRP3 PPP3CA PPP3CB RNF111 TRIM65 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2K UBE2M UBE2N USP7
Entrez ID		149371	64844
HPRD ID		09943	09817
Ensembl ID		ENSG00000116903	ENSG00000136536
Uniprot IDs		Q8IYI6	B7Z5K0 B7ZAR7 F5H6W4 Q9H992
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization Protein Binding Supramolecular Fiber Organization Intermediate Filament Organelle Organization Structural Molecule Activity Negative Regulation Of Viral Transcription Cytoskeleton Regulation Of Viral Transcription Regulation Of Post-translational Protein Modification Regulation Of Protein Autoubiquitination Molecular Adaptor Activity Cytoskeleton Organization Identical Protein Binding Phosphatidylinositol 3-kinase Inhibitor Activity Cellular Localization Vesicle-mediated Transport To The Plasma Membrane Regulation Of Lysosome Size BORC Complex Post-mRNA Release Spliceosomal Complex Gamma-tubulin Binding Autophagosome Epidermis Development	Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Post-translational Protein Modification Protein Polyubiquitination Protein Ubiquitination Protein K48-linked Ubiquitination Cytosol Protein Modification Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Macromolecule Catabolic Process Mitotic Spindle Astral Microtubule End Calmodulin-dependent Protein Phosphatase Activity Macromolecule Metabolic Process Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Protein Monoubiquitination Catabolic Process Protein Serine/threonine Phosphatase Complex Positive Regulation Of Metabolic Process Positive Regulation Of Calcium Ion Import Across Plasma Membrane Ubiquitin Protein Ligase Activity TORC1 Signaling Regulation Of Microtubule Polymerization Negative Regulation Of TORC1 Signaling Regulation Of Autophagy Positive Regulation Of Protein Modification Process Cytoplasm Regulation Of Protein Modification Process Positive Regulation Of Protein-containing Complex Assembly Protein Polymerization Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Protein Localization To Microtubule Transferase Activity TOR Signaling Regulation Of Protein-containing Complex Assembly ATP Binding Organelle Assembly Negative Regulation Of TOR Signaling Regulation Of Calcium-mediated Signaling Positive Regulation Of Protein Polyubiquitination Microtubule Organizing Center Positive Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of TORC1 Signaling Regulation Of Microtubule Polymerization Or Depolymerization
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