CSTF2 and CSTF3

Number of citations of the paper that reports this interaction (PMID 10669729)
78

Data Source:
BioGRID (pull down, affinity chromatography technology, biochemical)
HPRD (in vitro)

		CSTF2	CSTF3
Gene Name		cleavage stimulation factor, 3 pre-RNA, subunit 2, 64kDa	cleavage stimulation factor, 3 pre-RNA, subunit 3, 77kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex Cleavage Body	Nucleus Nucleoplasm
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding Poly(A) RNA Binding	RNA Binding MRNA Binding Poly(A) RNA Binding
	Biological Process	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Polyadenylation MRNA Cleavage RNA Splicing Gene Expression MRNA 3'-end Processing	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Polyadenylation MRNA Cleavage RNA Splicing Gene Expression MRNA 3'-end Processing
Pathways		mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Processing of Capped Intronless Pre-mRNA mRNA Splicing - Major Pathway Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing Processing of Intronless Pre-mRNAs	mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Processing of Capped Intronless Pre-mRNA mRNA Splicing - Major Pathway Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing Processing of Intronless Pre-mRNAs
Drugs
Diseases
GWAS
Protein-Protein Interactions		23 interactors: APP BAG6 C14orf1 CHD3 CSTF3 DDX1 ECH1 EEF1G FEZ1 HGS IKBKAP IMMT KAT5 KIAA1377 POLR2A SPAG8 SS18L1 SUB1 SYMPK TFG UBQLN1 UBQLN4 ZNF341	4 interactors: CPSF1 CSTF1 CSTF2 RRAGA
Entrez ID		1478	1479
HPRD ID		02652	02651
Ensembl ID		ENSG00000101811	ENSG00000176102
Uniprot IDs		E7EWR4 P33240	Q12996
PDB IDs		1P1T 2J8P
Enriched GO Terms of Interacting Partners?		MRNA Polyadenylation Gene Expression RNA Polyadenylation RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process MRNA Processing MRNA 3'-end Processing Regulation Of Protein Metabolic Process MRNA Metabolic Process RNA 3'-end Processing Regulation Of Gene Expression Regulation Of Metabolic Process RNA Processing Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Chromosome Organization Regulation Of Cellular Protein Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression Chromatin Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Transcription Elongation From RNA Polymerase II Promoter Transcription, RNA-templated Synaptic Growth At Neuromuscular Junction Nitrogen Compound Metabolic Process Regulation Of Dendrite Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Modification Regulation Of Epidermal Growth Factor Receptor Signaling Pathway DNA Duplex Unwinding DNA Geometric Change Regulation Of ERBB Signaling Pathway Collateral Sprouting In Absence Of Injury DNA-templated Transcription, Elongation Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process RNA Splicing Regulation Of Dendrite Development Collateral Sprouting Axon Midline Choice Point Recognition	MRNA Cleavage MRNA Polyadenylation RNA Polyadenylation Termination Of RNA Polymerase II Transcription DNA-templated Transcription, Termination MRNA 3'-end Processing RNA 3'-end Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleic Acid Phosphodiester Bond Hydrolysis RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing Transcription From RNA Polymerase II Promoter Positive Regulation Of Cytolysis Transcription, DNA-templated Positive Regulation Of TOR Signaling Modulation By Virus Of Host Morphology Or Physiology RNA Biosynthetic Process RNA Metabolic Process Regulation Of TOR Signaling Cellular Response To Amino Acid Stimulus Gene Expression MRNA Export From Nucleus RNA Export From Nucleus Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Interaction With Host Regulation Of Autophagy
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