CRX and ZNF688

Number of citations of the paper that reports this interaction (PubMedID 26871637)
43

Data Source:
BioGRID (two hybrid)

		CRX	ZNF688
Description		cone-rod homeobox	zinc finger protein 688
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex RNA Polymerase II Transcription Regulator Complex	Nucleus
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Nuclear Receptor Binding Leucine Zipper Domain Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Visual Perception Animal Organ Morphogenesis Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Retina Development In Camera-type Eye	Regulation Of DNA-templated Transcription
Pathways			Generic Transcription Pathway
Drugs
Diseases		Leber congenital amaurosis (LCR) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		DHEAS levels ( 34748635) Serum metabolite levels ( 33031748)
Interacting Genes		111 interacting genes: AASDHPPT ABI2 ACBD4 AIRIM ARIH2 ATG12 ATM ATP6V0D2 ATXN1 ATXN7 BANF1 BANF2 BANP BOD1L2 C19orf25 C1orf50 C1orf56 C9orf72 CA8 CCNC CDKN2C CFAP206 CIMIP4 CREBBP CSNK1G2-AS1 CTNNA3 DELE1 EIF5A EP300 FAAP20 FOXH1 GCM2 GLIS2 GUCD1 GYS1 HGS HNF1B IGFN1 IPO13 IRX6 KANK2 KAT2A KLHL32 LARP4 LGALS3 LIMS3 LIMS4 LNX1 LONRF1 M1AP MDFI MLLT6 MYO15B MYOZ1 NEIL2 NFYC NIP7 NPAS2 NR2E3 NRL NTF4 OR6B1 OSGIN1 OSTF1 PDC PICALM PID1 PNMA6A POGZ PPP1R16B PRKAB2 PRKN PRR35 PSMA1 PSMB10 PSMF1 QRICH1 RAX2 RBFOX1 RBPMS RHOXF2 ROR2 SAE1 SDCBP SEC14L4 SFI1 SMAD3 SMAP1 SMAP2 SMUG1 SOX10 SOX14 SOX3 SOX5 SPG21 STK16 SUFU SUOX SZT2 TBX6 TCF7L2 TFG TLX3 TNS2 UBXN2B UBXN7 VPS37C ZC3H10 ZIC1 ZNF483 ZNF688	111 interacting genes: ABI2 AIRIM ANKRD11 BEND5 BLZF1 BOLA2 BOLA2B CADPS CALCOCO2 CARD9 CATSPER1 CBY2 CCDC102B CCDC136 CCDC33 CCDC57 CCNC CDKN2D CDR2L CEP44 CEP70 CEP72 CIB3 CRX DEF6 EHMT2 FAM90A1 FBXO7 FCHO1 FHL5 GEM GLYCTK GMPPA GOLGA2 GPANK1 GPRASP2 HMBOX1 HNRNPK HOMEZ HOXA1 HSF2BP IGFN1 IHO1 KHDRBS2 KHDRBS3 KIFC3 KRT13 KRT15 KRT31 KRT40 KRTAP10-3 KRTAP10-9 KRTAP12-2 KRTAP4-2 LDOC1 LMO1 LMO2 MAGED1 MDFI MEOX2 MID2 MIPOL1 MKRN3 MYOZ3 NCK2 NEK6 NFU1 NOTCH2NLA OSTF1 PCBD1 PFKFB1 PHF1 PIH1D2 PLSCR1 PNMA1 PNMA2 POLR1C PSMA3 PSMB1 PSTPIP1 RCOR3 REL RFX6 RINT1 RPGRIP1 SCNM1 SMARCB1 SPAG5 SSX2IP TADA2A TCEANC TCF12 TCF4 TCP11 TEKT4 TENT5B TLE5 TMCC2 TNS2 TRAF1 TRAF2 TRAF4 TRIM23 TRIM27 TRIP6 TTC19 USHBP1 WWP2 ZC4H2 ZGPAT ZNF330
Entrez ID		1406	146542
HPRD ID		03748	14070
Ensembl ID		ENSG00000105392	ENSG00000229809
Uniprot IDs		O43186	A0A0S2Z5X4 A0A0S2Z633 P0C7X2
PDB IDs		9B8U
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Histone H3K18 Acetyltransferase Activity Chromatin Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process DNA Binding Protein Binding Nucleus Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cytoplasm Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Regulator Complex Histone H3K27 Acetyltransferase Activity Positive Regulation Of Protein Localization To Nucleus Beta-catenin Binding Ubiquitin Binding Central Nervous System Development Pattern Specification Process Peptidyl-lysine Acetylation Regulation Of Protein Localization To Nucleus Macroautophagy DNA-binding Transcription Factor Activity Regulation Of Gene Expression Promoter-specific Chromatin Binding Regulation Of Cellular Response To Heat N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Regulation Of Primary Metabolic Process Developmental Growth Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Acetyltransferase Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gluconeogenesis Regulation Of Exosomal Secretion Somitogenesis Proteasome Core Complex	Protein Binding Identical Protein Binding Keratin Filament Nucleus Intermediate Filament Signaling Adaptor Activity Cytoskeleton Thioesterase Binding Transcription Coactivator Activity Microtubule Organizing Center Organization
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