CRX and OSTF1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CRX	OSTF1
Description		cone-rod homeobox	osteoclast stimulating factor 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex RNA Polymerase II Transcription Regulator Complex	Extracellular Region Cytoplasm Secretory Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Nuclear Receptor Binding Leucine Zipper Domain Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Protein Binding SH3 Domain Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Visual Perception Animal Organ Morphogenesis Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Retina Development In Camera-type Eye	Ossification Signal Transduction
Pathways			Neutrophil degranulation
Drugs
Diseases		Leber congenital amaurosis (LCR) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		DHEAS levels ( 34748635) Serum metabolite levels ( 33031748)	Allergic rhinitis ( 25085501) Glucose homeostasis traits ( 25524916) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Resting-state electroencephalogram vigilance ( 29703947) Systemic sclerosis ( 30247649) Urinary magnesium-to-creatinine ratio ( 29093028)
Interacting Genes		111 interacting genes: AASDHPPT ABI2 ACBD4 AIRIM ARIH2 ATG12 ATM ATP6V0D2 ATXN1 ATXN7 BANF1 BANF2 BANP BOD1L2 C19orf25 C1orf50 C1orf56 C9orf72 CA8 CCNC CDKN2C CFAP206 CIMIP4 CREBBP CSNK1G2-AS1 CTNNA3 DELE1 EIF5A EP300 FAAP20 FOXH1 GCM2 GLIS2 GUCD1 GYS1 HGS HNF1B IGFN1 IPO13 IRX6 KANK2 KAT2A KLHL32 LARP4 LGALS3 LIMS3 LIMS4 LNX1 LONRF1 M1AP MDFI MLLT6 MYO15B MYOZ1 NEIL2 NFYC NIP7 NPAS2 NR2E3 NRL NTF4 OR6B1 OSGIN1 OSTF1 PDC PICALM PID1 PNMA6A POGZ PPP1R16B PRKAB2 PRKN PRR35 PSMA1 PSMB10 PSMF1 QRICH1 RAX2 RBFOX1 RBPMS RHOXF2 ROR2 SAE1 SDCBP SEC14L4 SFI1 SMAD3 SMAP1 SMAP2 SMUG1 SOX10 SOX14 SOX3 SOX5 SPG21 STK16 SUFU SUOX SZT2 TBX6 TCF7L2 TFG TLX3 TNS2 UBXN2B UBXN7 VPS37C ZC3H10 ZIC1 ZNF483 ZNF688	51 interacting genes: AGR2 APP BORCS6 CBL CBLB CCDC33 CRX CTDSP1 CUEDC1 DPPA4 DTX3 EFS ERRFI1 FASLG FBXO7 GAPDH GGN HES7 HTT KHDRBS1 KLHL42 LATS1 LMNA MAPK6 MED19 MEOX2 NFYC NUTM1 NUTM2F PBX4 PICK1 PRRG4 REL SDCBP SF1 SF3A2 SMN1 SNW1 SOCS7 SYNGAP1 TRIB3 TRIM54 VPS37B WASF1 WASHC1 WASL YPEL3 ZBTB42 ZBTB7B ZNF655 ZNF688
Entrez ID		1406	26578
HPRD ID		03748	17808
Ensembl ID		ENSG00000105392	ENSG00000134996
Uniprot IDs		O43186	Q92882
PDB IDs		9B8U	1X2K 1ZLM 3EHQ 3EHR
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Histone H3K18 Acetyltransferase Activity Chromatin Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process DNA Binding Protein Binding Nucleus Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cytoplasm Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Regulator Complex Histone H3K27 Acetyltransferase Activity Positive Regulation Of Protein Localization To Nucleus Beta-catenin Binding Ubiquitin Binding Central Nervous System Development Pattern Specification Process Peptidyl-lysine Acetylation Regulation Of Protein Localization To Nucleus Macroautophagy DNA-binding Transcription Factor Activity Regulation Of Gene Expression Promoter-specific Chromatin Binding Regulation Of Cellular Response To Heat N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Regulation Of Primary Metabolic Process Developmental Growth Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Acetyltransferase Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gluconeogenesis Regulation Of Exosomal Secretion Somitogenesis Proteasome Core Complex	Regulation Of Receptor-mediated Endocytosis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway SH3 Domain Binding Regulation Of ERBB Signaling Pathway Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Synapse Structure Or Activity Regulation Of Receptor Internalization Nucleus Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway MRNA 3'-splice Site Recognition Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Transcription By RNA Polymerase II Establishment Of Organelle Localization Regulation Of Actin Nucleation Neuron Projection Organization Cytoskeleton-dependent Intracellular Transport Regulation Of Endocytosis Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Positive Regulation Of Cellular Component Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Localization Spliceosomal Complex Assembly Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Protein Binding Regulation Of Intracellular Signal Transduction Regulation Of Primary Metabolic Process Regulation Of Signal Transduction Arp2/3 Complex Binding Regulation Of Supramolecular Fiber Organization Regulation Of Metabolic Process Regulation Of Plasma Membrane Organization Negative Regulation Of Alpha-beta T Cell Proliferation Localization Within Membrane Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Regulation Of RNA Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Endocytosis Regulation Of Cell Communication Regulation Of Signaling Regulation Of Extrinsic Apoptotic Signaling Pathway
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