CRX and UBXN2B

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		CRX	UBXN2B
Description		cone-rod homeobox	UBX domain protein 2B
Image
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex RNA Polymerase II Transcription Regulator Complex	Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Centrosome Cytosol Cytoskeleton Spindle Pole Centrosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Nuclear Receptor Binding Leucine Zipper Domain Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Ubiquitin Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Visual Perception Animal Organ Morphogenesis Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Retina Development In Camera-type Eye	Autophagosome Assembly Establishment Of Mitotic Spindle Orientation Golgi Organization Nuclear Membrane Reassembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Centrosome Separation Membrane Fusion Negative Regulation Of Protein Localization To Centrosome
Pathways
Drugs
Diseases		Leber congenital amaurosis (LCR) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		DHEAS levels ( 34748635) Serum metabolite levels ( 33031748)	Gallstone disease ( 27094239) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Loneliness ( 27629369) Low density lipoprotein cholesterol levels ( 29403010 33339817) Medication use (HMG CoA reductase inhibitors) ( 31015401) Narcolepsy with cataplexy ( 23496005) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Total cholesterol levels ( 29403010 33339817) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		111 interacting genes: AASDHPPT ABI2 ACBD4 AIRIM ARIH2 ATG12 ATM ATP6V0D2 ATXN1 ATXN7 BANF1 BANF2 BANP BOD1L2 C19orf25 C1orf50 C1orf56 C9orf72 CA8 CCNC CDKN2C CFAP206 CIMIP4 CREBBP CSNK1G2-AS1 CTNNA3 DELE1 EIF5A EP300 FAAP20 FOXH1 GCM2 GLIS2 GUCD1 GYS1 HGS HNF1B IGFN1 IPO13 IRX6 KANK2 KAT2A KLHL32 LARP4 LGALS3 LIMS3 LIMS4 LNX1 LONRF1 M1AP MDFI MLLT6 MYO15B MYOZ1 NEIL2 NFYC NIP7 NPAS2 NR2E3 NRL NTF4 OR6B1 OSGIN1 OSTF1 PDC PICALM PID1 PNMA6A POGZ PPP1R16B PRKAB2 PRKN PRR35 PSMA1 PSMB10 PSMF1 QRICH1 RAX2 RBFOX1 RBPMS RHOXF2 ROR2 SAE1 SDCBP SEC14L4 SFI1 SMAD3 SMAP1 SMAP2 SMUG1 SOX10 SOX14 SOX3 SOX5 SPG21 STK16 SUFU SUOX SZT2 TBX6 TCF7L2 TFG TLX3 TNS2 UBXN2B UBXN7 VPS37C ZC3H10 ZIC1 ZNF483 ZNF688	16 interacting genes: CRX INCA1 MEOX1 MEOX2 NGLY1 PAX5 PAX6 PIN1 PPP1R11 PPP1R3A PPP1R7 UBC UBXN6 VAT1L VCP XAF1
Entrez ID		1406	137886
HPRD ID		03748	18973
Ensembl ID		ENSG00000105392	ENSG00000215114
Uniprot IDs		O43186	E5RJ36 Q14CS0
PDB IDs		9B8U	8B5R
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Histone H3K18 Acetyltransferase Activity Chromatin Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process DNA Binding Protein Binding Nucleus Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cytoplasm Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Regulator Complex Histone H3K27 Acetyltransferase Activity Positive Regulation Of Protein Localization To Nucleus Beta-catenin Binding Ubiquitin Binding Central Nervous System Development Pattern Specification Process Peptidyl-lysine Acetylation Regulation Of Protein Localization To Nucleus Macroautophagy DNA-binding Transcription Factor Activity Regulation Of Gene Expression Promoter-specific Chromatin Binding Regulation Of Cellular Response To Heat N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Regulation Of Primary Metabolic Process Developmental Growth Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Acetyltransferase Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gluconeogenesis Regulation Of Exosomal Secretion Somitogenesis Proteasome Core Complex	Somite Specification Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nucleus HMG Box Domain Binding Segment Specification Somite Development DNA-binding Transcription Factor Activity Protein Phosphatase 1 Binding Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Cis-trans Isomerase Activity Flavin Adenine Dinucleotide Catabolic Process Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Sorting Pathway Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Retina Development In Camera-type Eye Sclerotome Development Embryonic Pattern Specification Cerebral Cortex Development Habenula Development Pallium Development Ubiquitin Protein Ligase Binding Protein Peptidyl-prolyl Isomerization Phosphothreonine Residue Binding Modification-dependent Protein Catabolic Process VCP-NSFL1C Complex Cellular Response To Arsenite Ion Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Endosome To Lysosome Transport Mitotic Spindle Disassembly Positive Regulation Of Oxidative Phosphorylation Positive Regulation Of Protein K63-linked Deubiquitination Regulation Of Asymmetric Cell Division Oligodendrocyte Cell Fate Specification Proteolysis Cytoplasm Protein Quality Control ERAD Pathway
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