CRX and NRL

Number of citations of the paper that reports this interaction (PubMedID 10887186)
0

Data Source:
HPRD (two hybrid, in vitro)

		CRX	NRL
Description		cone-rod homeobox	neural retina leucine zipper
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Nuclear Receptor Binding Leucine Zipper Domain Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Leucine Zipper Domain Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Visual Perception Animal Organ Morphogenesis Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Retina Development In Camera-type Eye	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Visual Perception Positive Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Retinal Rod Cell Development
Pathways
Drugs
Diseases		Leber congenital amaurosis (LCR) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)	Retinitis pigmentosa (RP)
GWAS		DHEAS levels ( 34748635) Serum metabolite levels ( 33031748)	Attention deficit hyperactivity disorder symptom score ( 27663945) Liver fibrosis and steatohepatitis severity (MRI cT1 measure) ( 32247823) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		111 interacting genes: AASDHPPT ABI2 ACBD4 AIRIM ARIH2 ATG12 ATM ATP6V0D2 ATXN1 ATXN7 BANF1 BANF2 BANP BOD1L2 C19orf25 C1orf50 C1orf56 C9orf72 CA8 CCNC CDKN2C CFAP206 CIMIP4 CREBBP CSNK1G2-AS1 CTNNA3 DELE1 EIF5A EP300 FAAP20 FOXH1 GCM2 GLIS2 GUCD1 GYS1 HGS HNF1B IGFN1 IPO13 IRX6 KANK2 KAT2A KLHL32 LARP4 LGALS3 LIMS3 LIMS4 LNX1 LONRF1 M1AP MDFI MLLT6 MYO15B MYOZ1 NEIL2 NFYC NIP7 NPAS2 NR2E3 NRL NTF4 OR6B1 OSGIN1 OSTF1 PDC PICALM PID1 PNMA6A POGZ PPP1R16B PRKAB2 PRKN PRR35 PSMA1 PSMB10 PSMF1 QRICH1 RAX2 RBFOX1 RBPMS RHOXF2 ROR2 SAE1 SDCBP SEC14L4 SFI1 SMAD3 SMAP1 SMAP2 SMUG1 SOX10 SOX14 SOX3 SOX5 SPG21 STK16 SUFU SUOX SZT2 TBX6 TCF7L2 TFG TLX3 TNS2 UBXN2B UBXN7 VPS37C ZC3H10 ZIC1 ZNF483 ZNF688	7 interacting genes: CRX EDF1 FIZ1 MAPK1 MAPK14 NR2E3 UBR5
Entrez ID		1406	4901
HPRD ID		03748	08875
Ensembl ID		ENSG00000105392	ENSG00000129535
Uniprot IDs		O43186	P54845
PDB IDs		9B8U
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Histone H3K18 Acetyltransferase Activity Chromatin Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process DNA Binding Protein Binding Nucleus Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cytoplasm Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Regulator Complex Histone H3K27 Acetyltransferase Activity Positive Regulation Of Protein Localization To Nucleus Beta-catenin Binding Ubiquitin Binding Central Nervous System Development Pattern Specification Process Peptidyl-lysine Acetylation Regulation Of Protein Localization To Nucleus Macroautophagy DNA-binding Transcription Factor Activity Regulation Of Gene Expression Promoter-specific Chromatin Binding Regulation Of Cellular Response To Heat N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Regulation Of Primary Metabolic Process Developmental Growth Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Acetyltransferase Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gluconeogenesis Regulation Of Exosomal Secretion Somitogenesis Proteasome Core Complex	Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process MAP Kinase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Protein Import Into Nucleus Regulation Of Intracellular Transport Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Retina Development In Camera-type Eye Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Intracellular Protein Transport Cellular Response To Tumor Necrosis Factor Positive Regulation Of Protein Localization To Nucleus Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cytosine Metabolic Process Nuclear Receptor-mediated Signaling Pathway Heterochromatin Boundary Formation Regulation Of Cellular Localization Nucleus Regulation Of Transcription By RNA Polymerase II Regulation Of Ossification Regulation Of Nucleocytoplasmic Transport Response To Tumor Necrosis Factor Ficolin-1-rich Granule Lumen Regulation Of Synaptic Membrane Adhesion Interleukin-34-mediated Signaling Pathway Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System Positive Regulation Of Intracellular Transport Regulation Of Intracellular Protein Transport Hormone-mediated Signaling Pathway Regulation Of Golgi Inheritance Cytoplasm Protein Quality Control
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