LATS1 and TAZ

Number of citations of the paper that reports this interaction (PMID 24107629)
5

Data Source:
BioGRID (unspecified method)

		LATS1	TAZ
Gene Name		large tumor suppressor kinase 1	tafazzin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Spindle Pole Microtubule Organizing Center Cytosol	Nucleus Mitochondrion Mitochondrial Inner Membrane Cytosol Integral Component Of Membrane Intrinsic Component Of Membrane Mitochondrial Membrane
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding	1-acylglycerophosphocholine O-acyltransferase Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Sister Chromatid Segregation Protein Phosphorylation Mitotic Nuclear Division Hormone-mediated Signaling Pathway Keratinocyte Differentiation Regulation Of Actin Filament Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Hippo Signaling Regulation Of Protein Complex Assembly Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cytoplasmic Sequestering Of Protein Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway	Phospholipid Metabolic Process Muscle Contraction Heart Development Skeletal Muscle Tissue Development Hemopoiesis Cardiolipin Biosynthetic Process Mitochondrial Respiratory Chain Complex I Assembly Cardiolipin Acyl-chain Remodeling Cristae Formation Mitochondrial ATP Synthesis Coupled Electron Transport Small Molecule Metabolic Process Glycerophospholipid Biosynthetic Process Cardiac Muscle Tissue Development Cardiac Muscle Contraction
Pathways		Signaling by Hippo	Acyl chain remodeling of CL Metabolism of lipids and lipoproteins Mitochondrial protein import Phospholipid metabolism Glycerophospholipid biosynthesis
Drugs
Diseases
GWAS
Protein-Protein Interactions		43 interactors: ALPP AMOT APP AURKB CAV1 CDK1 CEP76 EIF4EBP1 FOXL2 FSD2 GOLGA2 ITCH KRT31 LDOC1 LIMK1 MAGI3 MOAP1 MOB3A MOB3B MOB3C MOB4 NEDD4 NUAK1 NUAK2 PABPN1 PPP1R11 PPP6R3 PTEN RAC1 SMURF1 SMURF2 SPERT SSX2IP STK3 STK4 TAZ TFIP11 TRAF1 WWOX WWP1 WWTR1 YAP1 ZYX	9 interactors: BTRC CHGB CSNK1E GSK3B LATS1 LATS2 RUNX1 SLC9A3R2 YWHAE
Entrez ID		9113	6901
HPRD ID		09147	02316
Ensembl ID		ENSG00000131023	ENSG00000102125
Uniprot IDs		O95835	Q16635
PDB IDs
Enriched GO Terms of Interacting Partners?		Hippo Signaling Regulation Of Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Signaling Intracellular Signal Transduction Regulation Of Wnt Signaling Pathway Regulation Of Apoptotic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Death Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Metabolic Process Regulation Of Protein Binding Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Signaling Tissue Development Cellular Protein Catabolic Process Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Cellular Response To Growth Factor Stimulus Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Anatomical Structure Morphogenesis Regulation Of Kinase Activity Signal Transduction Response To Growth Factor Cell Communication Positive Regulation Of Signal Transduction Regulation Of Developmental Growth Protein Catabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Protein Metabolic Process Response To Transforming Growth Factor Beta Cellular Macromolecule Catabolic Process Regulation Of Cell Development Negative Regulation Of Wnt Signaling Pathway Regulation Of Organ Growth Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Signaling Regulation Of Protein Kinase Activity Negative Regulation Of Cellular Metabolic Process	Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Signal Transduction G2/M Transition Of Mitotic Cell Cycle Hippo Signaling Regulation Of Signaling Cell Cycle Process Negative Regulation Of Signal Transduction Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Signaling Regulation Of Canonical Wnt Signaling Pathway Cell Cycle Mitotic Cell Cycle Process Mitotic Cell Cycle Regulation Of Wnt Signaling Pathway Cellular Response To Organic Substance Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Protein Metabolic Process Circadian Rhythm Cellular Protein Localization Regulation Of Proteasomal Protein Catabolic Process Response To Organic Substance Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Proteolysis Negative Regulation Of Protein Kinase Activity Positive Regulation Of Protein Catabolic Process Regulation Of Cellular Response To Heat Skin Development Negative Regulation Of Kinase Activity Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Epidermis Development Wnt Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Organ Development Tissue Development Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Rhythmic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Protein Phosphorylation Protein Localization Positive Regulation Of Mitochondrion Organization Cellular Response To Heat Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process
Tagcloud ?		accompanying carcinogenic cdc2 conservation corpus flies homologue hyperplastic hypogonadism hypogonadotropic infertility insufficiency lethality lh luteum mammalian melanogaster mosaic pituitary ref reminiscent reproductive rescues retardation sarcomas screens tumorigenesis tumours	ages avoid bacteriological careful chest chromatographically clarify clearance comprised creatinine deliberate elderly evaluations impairment influencing japanese late nephrotoxicity pay pharmacokinetic pharmacokinetics pilot pipc piperacillin planning pneumonia rays serious tazobactam
Tagcloud (Difference) ?		accompanying carcinogenic cdc2 conservation corpus flies homologue hyperplastic hypogonadism hypogonadotropic infertility insufficiency lethality lh luteum mammalian melanogaster mosaic pituitary ref reminiscent reproductive rescues retardation sarcomas screens tumorigenesis tumours	ages avoid bacteriological careful chest chromatographically clarify clearance comprised creatinine deliberate elderly evaluations impairment influencing japanese late nephrotoxicity pay pharmacokinetic pharmacokinetics pilot pipc piperacillin planning pneumonia rays serious tazobactam
Tagcloud (Intersection) ?