SLBP and ERI1

Number of citations of the paper that reports this interaction (PubMedID 14536070)
0

Data Source:
BioGRID (two hybrid)

		SLBP	ERI1
Description		stem-loop histone mRNA binding protein	exoribonuclease 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Histone MRNA Stem-loop Binding Complex Histone Pre-mRNA 3'end Processing Complex Ribonucleoprotein Complex	Nucleus Nucleolus Cytoplasm Histone Pre-mRNA 3'end Processing Complex
	Molecular Function	RNA Binding MRNA Binding Protein Binding Identical Protein Binding Histone Pre-mRNA Stem-loop Binding Histone Pre-mRNA DCP Binding	3'-5'-RNA Exonuclease Activity Nucleic Acid Binding RNA Binding Nuclease Activity Exonuclease Activity Protein Binding 3'-5' Exonuclease Activity Hydrolase Activity RRNA Binding Ribosome Binding Metal Ion Binding Histone Pre-mRNA Stem-loop Binding
	Biological Process	Cap-dependent Translational Initiation MRNA Processing MRNA 3'-end Processing By Stem-loop Binding And Cleavage MRNA Transport	Maturation Of 5.8S RRNA Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Regulatory NcRNA-mediated Gene Silencing RRNA 3'-end Processing Histone MRNA Catabolic Process
Pathways		Transport of the SLBP Dependant Mature mRNA RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Hip circumference adjusted for BMI ( 25673412 34021172) Hip index ( 34021172) Hip minimal joint space width ( 27701424) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483) Subcortical volume (MOSTest) ( 32665545) Urinary bladder cancer ( 20348956)	A body shape index ( 34021172) Acne (severe) ( 24927181) Bipolar disorder (early vs late onset) ( 34016946) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Eosinophil percentage of white cells ( 32888494) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 32888494) Medication use (diuretics) ( 31015401) Morning person ( 30696823) Neuroticism ( 29255261) Platelet distribution width ( 32888494 27863252) Processed meat consumption ( 32066663) Red cell distribution width ( 32888494) Refractive error ( 32231278) Schizophrenia ( 28991256) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		12 interacting genes: CDK1 CDK2 CDK4 CDK6 CEBPA CSNK2A1 DCAF11 ERI1 LSM10 PTGER4 USP8 ZNF473	3 interacting genes: OGT SLBP VHL
Entrez ID		7884	90459
HPRD ID		03884	11784
Ensembl ID		ENSG00000163950	ENSG00000104626
Uniprot IDs		B3KSC5 B3KST9 B4DUW7 E7EUV9 Q14493 Q53XR2	Q8IV48
PDB IDs		2KJM 4L8R 4QOZ	1W0H 1ZBH 1ZBU 4L8R 4QOZ
Enriched GO Terms of Interacting Partners?		Cyclin Binding Cyclin-dependent Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Kinase Holoenzyme Complex Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Histone MRNA Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Kinase Activity Regulation Of Cell Cycle G2/M Phase Transition Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Protein Serine Kinase Activity Negative Regulation Of Cell Cycle Cell Cycle Phase Transition Regulation Of Cell Cycle Histone Kinase Activity MRNA 3'-end Processing By Stem-loop Binding And Cleavage Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle Process Cajal Body Response To Ketone Cellular Response To Oxygen-containing Compound Negative Regulation Of Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Protein Kinase Activity RNA 3'-end Processing Regulation Of Macromolecule Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Metabolic Process DNA Damage Checkpoint Signaling Kinase Activity Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Cycle Phase Transition Negative Regulation Of Hemopoiesis Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Mitotic Cell Cycle Nucleoplasm Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Catabolic Process Protein Localization To Site Of Double-strand Break Intracellular Signal Transduction Regulation Of Transcription By RNA Polymerase II Signal Transduction In Response To DNA Damage Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA Damage Response	Regulation Of TOR Signaling Regulation Of TORC1 Signaling Histone MRNA Stem-loop Binding Complex Histone Pre-mRNA Stem-loop Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Histone Pre-mRNA DCP Binding Cap-dependent Translational Initiation MRNA 3'-end Processing By Stem-loop Binding And Cleavage Histone Pre-mRNA 3'end Processing Complex Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Carbon Catabolite Regulation Of Transcription Transcription Elongation Factor Activity Negative Regulation Of Catabolic Process Regulation Of Transcription By Glucose NSL Complex Regulation Of Cellular Response To Hypoxia Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Protein Serine/threonine Kinase Binding Negative Regulation Of Transcription Elongation By RNA Polymerase II Histone MRNA Metabolic Process Acetylglucosaminyltransferase Activity Histone Acetyltransferase Complex Sin3-type Complex Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
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