SLBP and CDK6

Number of citations of the paper that reports this interaction (PMID 22094256)
37

Data Source:
BioGRID (enzymatic study)

		SLBP	CDK6
Gene Name		stem-loop binding protein	cyclin-dependent kinase 6
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Ribonucleoprotein Complex Histone Pre-mRNA 3'end Processing Complex	Cyclin-dependent Protein Kinase Holoenzyme Complex Ruffle Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	MRNA Binding Protein Binding Poly(A) RNA Binding Histone Pre-mRNA Stem-loop Binding Histone Pre-mRNA DCP Binding	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cyclin Binding
	Biological Process	Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription Histone MRNA 3'-end Processing MRNA Export From Nucleus Histone MRNA Metabolic Process Gene Expression MRNA 3'-end Processing Nuclear DNA Replication MRNA Transport	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Positive Regulation Of Cell-matrix Adhesion Type B Pancreatic Cell Development Protein Phosphorylation Cell Cycle Arrest Notch Signaling Pathway Negative Regulation Of Cell Proliferation Response To Virus Regulation Of Gene Expression Positive Regulation Of Gene Expression Astrocyte Development Dentate Gyrus Development Lateral Ventricle Development T Cell Differentiation In Thymus Gliogenesis Cell Dedifferentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Regulation Of Erythrocyte Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Fibroblast Proliferation Generation Of Neurons Negative Regulation Of Epithelial Cell Proliferation Cell Division Hematopoietic Stem Cell Differentiation Regulation Of Cell Motility Negative Regulation Of Cellular Senescence
Pathways		SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs Processing of Capped Intron-Containing Pre-mRNA Transport of the SLBP Dependant Mature mRNA RNA Polymerase II Transcription Transport of Mature mRNAs Derived from Intronless Transcripts Processing of Capped Intronless Pre-mRNA Transport of Mature Transcript to Cytoplasm Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination	Cyclin D associated events in G1 Oxidative Stress Induced Senescence G1 Phase Cellular Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs
Diseases
GWAS		Urinary bladder cancer ( 20348956)	Height ( 20881960 19343178 23563607 18391950 18391951 18391952) Rheumatoid arthritis ( 18794853) White blood cell count ( 20139978 21738479) White blood cell types ( 21738478)
Protein-Protein Interactions		6 interactors: CDK4 CDK6 ERI1 LSM10 USP8 ZNF473	92 interactors: ABI2 ANKRD12 AR ATF6B ATXN1 BCL11A CASC3 CBY1 CCND1 CCND3 CDC37 CDC6 CDK7 CDKN1A CDKN2A CDKN2B CDKN2C CDKN2D CLASRP CNOT7 CTNNB1 DAB1 DDIT3 DEDD2 EBF4 EIF4ENIF1 ELK1 EZH2 FOXM1 FOXO3 HIST1H1A HSF1 ISL1 KIF26B KLF10 LPIN1 MCM10 MCM2 MEF2D MLLT3 MSL3 MYC MZF1 N4BP1 NFATC3 NIPBL NUMA1 PCNA PML POGZ PPARGC1A PPHLN1 PPM1B PPP2CA PRX PSMA3 RB1 RBL1 RBL2 RBM23 RUNX1 SENP3 SIRT1 SLBP SNIP1 SORBS1 SOX10 SOX5 SRSF1 SRSF11 SRSF12 SRSF2 SRSF7 SSBP2 SYNPO2 TCEB3B TFDP1 TGFBR1 TJP2 TPX2 TRA2A TRA2B TRAK1 UHRF2 VGLL4 ZEB1 ZFP36 ZMYM3 ZNF101 ZNF174 ZNF335 ZSCAN1
Entrez ID		7884	1021
HPRD ID		03884	04533
Ensembl ID		ENSG00000163950	ENSG00000105810
Uniprot IDs		E7EUV9 Q14493 Q53XR2	A4D1G0 Q00534
PDB IDs		2KJM 4L8R	1BI7 1BI8 1BLX 1G3N 1JOW 1XO2 2EUF 2F2C 3NUP 3NUX 4AUA 4EZ5
Enriched GO Terms of Interacting Partners?		RNA 3'-end Processing Histone MRNA Metabolic Process Termination Of RNA Polymerase II Transcription Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Cell Division Positive Regulation Of Fibroblast Proliferation DNA-templated Transcription, Termination MRNA 3'-end Processing Regulation Of Fibroblast Proliferation Cell Dedifferentiation RNA Processing Positive Regulation Of Mitotic Cell Cycle Mitotic Cell Cycle Process Mitotic Cell Cycle G1/S Transition Of Mitotic Cell Cycle Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Regulation Of Cell Cycle Histone MRNA 3'-end Processing Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Cell Cycle Process RRNA 3'-end Processing Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Negative Regulation Of Cellular Senescence Positive Regulation Of Cell Size Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Cell Cycle Hematopoietic Stem Cell Differentiation Negative Regulation Of Cell Aging Protein K48-linked Deubiquitination Regulation Of Mitotic Cell Cycle Protein K63-linked Deubiquitination Dentate Gyrus Development Maturation Of 5.8S RRNA MRNA Processing Type B Pancreatic Cell Development Negative Regulation Of Cell Cycle Astrocyte Development Type B Pancreatic Cell Differentiation Negative Regulation Of Cell Cycle Arrest Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Lateral Ventricle Development Enteroendocrine Cell Differentiation Cellular Metabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle	RNA Metabolic Process Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Cell Cycle Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Cell Cycle Process Positive Regulation Of Cellular Biosynthetic Process Mitotic Cell Cycle Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Cycle Mitotic Cell Cycle Process Regulation Of Phosphorylation G1/S Transition Of Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Cellular Metabolic Process RNA Processing Regulation Of Protein Metabolic Process Regulation Of Cellular Process Negative Regulation Of Transcription From RNA Polymerase II Promoter
Tagcloud ?		arsenic canonical carcinogenesis carcinogenic chromosomes continued display dramatically end excess histones instability instead loop messenger metazoan missing mitosis mrnas notably poly polyadenylated polyadenylation possibly proteasomal stem susceptible tail terminate	a134c abp allelic ankyrin balb cdkn2a cdkn2b cdkn2c cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed
Tagcloud (Difference) ?		arsenic canonical carcinogenesis carcinogenic chromosomes continued display dramatically end excess histones instability instead loop messenger metazoan missing mitosis mrnas notably poly polyadenylated polyadenylation possibly proteasomal stem susceptible tail terminate	a134c abp allelic ankyrin balb cdkn2a cdkn2b cdkn2c cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed
Tagcloud (Intersection) ?