SLBP and USP8

Number of citations of the paper that reports this interaction (PMID 10982817)
48

Data Source:
HPRD (in vitro)

		SLBP	USP8
Gene Name		stem-loop binding protein	ubiquitin specific peptidase 8
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Ribonucleoprotein Complex Histone Pre-mRNA 3'end Processing Complex	Acrosomal Vesicle Nucleoplasm Cytoplasm Early Endosome Golgi Apparatus Cytosol Extrinsic Component Of Plasma Membrane Midbody Extrinsic Component Of Endosome Membrane
	Molecular Function	MRNA Binding Protein Binding Poly(A) RNA Binding Histone Pre-mRNA Stem-loop Binding Histone Pre-mRNA DCP Binding	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding SH3 Domain Binding
	Biological Process	Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription Histone MRNA 3'-end Processing MRNA Export From Nucleus Histone MRNA Metabolic Process Gene Expression MRNA 3'-end Processing Nuclear DNA Replication MRNA Transport	Mitotic Cytokinesis Endosome Organization Ras Protein Signal Transduction Cell Proliferation Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination
Pathways		SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs Processing of Capped Intron-Containing Pre-mRNA Transport of the SLBP Dependant Mature mRNA RNA Polymerase II Transcription Transport of Mature mRNAs Derived from Intronless Transcripts Processing of Capped Intronless Pre-mRNA Transport of Mature Transcript to Cytoplasm Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination	Signaling by ERBB2 Downregulation of ERBB2:ERBB3 signaling misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation regulation of FZD by ubiquitination XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS		Urinary bladder cancer ( 20348956)
Protein-Protein Interactions		6 interactors: CDK4 CDK6 ERI1 LSM10 USP8 ZNF473	30 interactors: BIRC6 CHMP1A CHMP1B CHMP2A CHMP2B CHMP4C CHMP7 DNAJB6 GRAP2 GRB2 KIF23 NBR1 PJA1 PLA2G2A RASGRF1 RNF41 SLBP SPP1 SRC STAM STAM2 TRIM54 TRIM55 TRIM63 UBC USP15 USP21 USP28 YWHAG YWHAQ
Entrez ID		7884	9101
HPRD ID		03884	04405
Ensembl ID		ENSG00000163950	ENSG00000138592
Uniprot IDs		E7EUV9 Q14493 Q53XR2	P40818
PDB IDs		2KJM 4L8R	1WHB 2A9U 2GFO 2GWF 3N3K
Enriched GO Terms of Interacting Partners?		RNA 3'-end Processing Histone MRNA Metabolic Process Termination Of RNA Polymerase II Transcription Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Cell Division Positive Regulation Of Fibroblast Proliferation DNA-templated Transcription, Termination MRNA 3'-end Processing Regulation Of Fibroblast Proliferation Cell Dedifferentiation RNA Processing Positive Regulation Of Mitotic Cell Cycle Mitotic Cell Cycle Process Mitotic Cell Cycle G1/S Transition Of Mitotic Cell Cycle Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Regulation Of Cell Cycle Histone MRNA 3'-end Processing Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Cell Cycle Process RRNA 3'-end Processing Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Negative Regulation Of Cellular Senescence Positive Regulation Of Cell Size Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Cell Cycle Hematopoietic Stem Cell Differentiation Negative Regulation Of Cell Aging Protein K48-linked Deubiquitination Regulation Of Mitotic Cell Cycle Protein K63-linked Deubiquitination Dentate Gyrus Development Maturation Of 5.8S RRNA MRNA Processing Type B Pancreatic Cell Development Negative Regulation Of Cell Cycle Astrocyte Development Type B Pancreatic Cell Differentiation Negative Regulation Of Cell Cycle Arrest Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Lateral Ventricle Development Enteroendocrine Cell Differentiation Cellular Metabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle	Cell Separation After Cytokinesis Regulation Of Mitotic Spindle Assembly Regulation Of Spindle Assembly Mitotic Metaphase Plate Congression Metaphase Plate Congression Regulation Of Mitotic Spindle Organization Establishment Of Chromosome Localization Vacuolar Transport Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Cell Cycle Process Regulation Of Centrosome Duplication Cell Cycle Mitotic Nuclear Division Regulation Of Centrosome Cycle Mitotic Cell Cycle Process Endosomal Transport Regulation Of Organelle Organization Nucleus Organization Mitotic Cell Cycle Regulation Of Cell Division Regulation Of Microtubule Cytoskeleton Organization Cell Division Membrane Organization Regulation Of Microtubule-based Process Regulation Of Cell Cycle Process Intracellular Transport Regulation Of Protein Complex Assembly Regulation Of Cellular Component Organization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Chromosome Segregation Negative Regulation Of ERBB Signaling Pathway Regulation Of Mitotic Nuclear Division Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Establishment Of Localization In Cell Regulation Of Cytoskeleton Organization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Establishment Of Organelle Localization Regulation Of ERBB Signaling Pathway Virion Assembly Viral Life Cycle Proteolysis Involved In Cellular Protein Catabolic Process Viral Process Regulation Of Cellular Process Cellular Protein Catabolic Process Protein Transport
Tagcloud ?		arsenic canonical carcinogenesis carcinogenic chromosomes continued display dramatically end excess histones instability instead loop messenger metazoan missing mitosis mrnas notably poly polyadenylated polyadenylation possibly proteasomal stem susceptible tail terminate	ampa ampar ampars antagonizes dephosphorylation deubiquitinating deubiquitination downscaling dub e3 forces homeostatic internalization inversely ligase lysosomes mechanistic nedd4 nmdar opposing plasticity redistributed scaling spines strength strikingly synapses synaptic ubiquitination
Tagcloud (Difference) ?		arsenic canonical carcinogenesis carcinogenic chromosomes continued display dramatically end excess histones instability instead loop messenger metazoan missing mitosis mrnas notably poly polyadenylated polyadenylation possibly proteasomal stem susceptible tail terminate	ampa ampar ampars antagonizes dephosphorylation deubiquitinating deubiquitination downscaling dub e3 forces homeostatic internalization inversely ligase lysosomes mechanistic nedd4 nmdar opposing plasticity redistributed scaling spines strength strikingly synapses synaptic ubiquitination
Tagcloud (Intersection) ?