PKMYT1 and MAPK8

Number of citations of the paper that reports this interaction (PubMedID 19204086)
51

Data Source:
BioGRID (pull down, enzymatic study)

		PKMYT1	MAPK8
Description		protein kinase, membrane associated tyrosine/threonine 1	mitogen-activated protein kinase 8
Image
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Axon Synapse Basal Dendrite
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Enzyme Binding Protein Phosphatase Binding Histone Deacetylase Regulator Activity Histone Deacetylase Binding Protein Serine Kinase Activity Protein Serine/threonine Kinase Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Regulation Of Mitotic Nuclear Division Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Meiotic Cell Cycle Negative Regulation Of G2/MI Transition Of Meiotic Cell Cycle	MAPK Cascade Double-strand Break Repair Protein Phosphorylation Response To Oxidative Stress JNK Cascade JUN Phosphorylation Response To UV Response To Mechanical Stimulus Positive Regulation Of Gene Expression Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Cyclase Activity Positive Regulation Of Cell Killing Negative Regulation Of Protein Binding Regulation Of Protein Localization Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Fc-epsilon Receptor Signaling Pathway Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of MRNA Stability NLRP3 Inflammasome Complex Assembly Rhythmic Process Positive Regulation Of Protein Metabolic Process Stress-activated MAPK Cascade MRNA Destabilization Protein Poly-ADP-ribosylation Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Senescence Energy Homeostasis Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein Localization To Site Of Double-strand Break
Pathways		Polo-like kinase mediated events Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint	Activation of BIM and translocation to mitochondria Activation of BMF and translocation to mitochondria NRAGE signals death through JNK NRAGE signals death through JNK NRIF signals cell death from the nucleus Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Activation of the AP-1 family of transcription factors Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Interleukin-38 signaling WNT5:FZD7-mediated leishmania damping Signaling by ALK fusions and activated point mutants
Drugs		Fostamatinib	Tamoxifen Minocycline Pyrazolanthrone 6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE 2-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDE N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE 5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE 2-fluoro-6-{[2-({2-methoxy-4-[(methylsulfonyl)methyl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide Halicin
Diseases
GWAS		Metabolic syndrome ( 20694148)	Blood protein levels in cardiovascular risk ( 28369058) Daytime sleep phenotypes ( 27126917) Opioid dependence (time to event) ( 34124712) Refractive error ( 32231278)
Interacting Genes		24 interacting genes: ABHD16A BCL2 CCNB1 CD3E CD79A CDK1 CLDN8 ELOVL4 FATE1 LIME1 LRRC25 MAPK10 MAPK8 PIN1 PLK1 RETREG3 SLC10A1 SLC30A8 SLC61A1 SLC71A2 STEAP3 TMEM101 TMEM229B TMX2	140 interacting genes: AIMP1 AKT1 APBB2 APLP2 APP ATF2 ATM BAD BCL2 BCL2L1 BCL2L11 BMF BMPR2 CAMP CASP3 CBL CCDC88C CDKN1A CDKN2A CDKN2C CEBPA COPS2 CRK CTNNB1 DUSP1 DUSP10 DUSP16 DUSP22 DUSP4 DUSP7 EEF2K EGFR ELK1 ELK3 ELK4 ELP1 EP300 ETV1 FAM193B FZR1 GANAB GARS1 GEMIN5 GFPT1 GORASP2 GSTP1 GUCY1A1 H2AX HDAC9 HIVEP1 HRAS HSD17B4 HSF1 HSF4 HSPA8 ID2 IL27RA IRAK1 IRF3 IRS1 ITCH JDP2 JKAMP JUN JUNB JUND KRT8 MAP1B MAP2K1 MAP2K2 MAP2K4 MAP2K7 MAP3K2 MAP3K7 MAPK1 MAPK14 MAPK3 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPKAP1 MAPKBP1 MAPT MBP METTL3 MKNK2 MYC NCOA3 NFATC3 NFATC4 NFE2 NFE2L2 NKAPD1 NR3C1 NR4A1 PAX2 PDPK1 PIAS2 PIK3R1 PKMYT1 PNRC1 PPARG PRKD1 PRKDC PXN RAD18 RAF1 RASSF1 RBM15 REL RET RPLP2 RPS6KB1 SCAND1 SCOC SERPINB3 SH3BP5 SHC1 SIRT1 SMAD2 SMAD3 SNCA SNCG SP1 SPAG9 SPI1 SPIB SSU72 STAT3 TFCP2 TNFSF11 TP53 TP73 TRAF6 WDR62 WWOX XRCC6 YWHAZ ZNF219 ZNF605
Entrez ID		9088	5599
HPRD ID		03920	03100
Ensembl ID		ENSG00000127564	ENSG00000107643
Uniprot IDs		Q0IJ49 Q99640	A1L4K2 P45983
PDB IDs		3P1A 5VCV 5VCW 5VCX 5VCY 5VCZ 5VD0 5VD1 5VD3 8D6C 8D6D 8D6E 8D6F 8WJY 8ZTX 8ZU2 8ZUD 8ZUL	1UKH 1UKI 2G01 2GMX 2H96 2NO3 2XRW 2XS0 3ELJ 3O17 3O2M 3PZE 3V3V 3VUD 3VUG 3VUH 3VUI 3VUK 3VUL 3VUM 4AWI 4E73 4G1W 4HYS 4HYU 4IZY 4L7F 4QTD 4UX9 4YR8 5LW1 6F5E 6ZR5 8PT8 8PT9 8PTA 8R5E 8X5M 9FT9
Enriched GO Terms of Interacting Partners?		Membrane Immune Response-regulating Cell Surface Receptor Signaling Pathway Cyclin B1-CDK1 Complex Protein Localization To Site Of Double-strand Break JUN Kinase Activity Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport B Cell Receptor Complex Immune Response-regulating Signaling Pathway Mitotic Cell Cycle Phase Transition Antigen Receptor-mediated Signaling Pathway B Cell Receptor Signaling Pathway G2/M Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Cell Cycle G2/M Phase Transition Ventricular Cardiac Muscle Cell Development Mitotic Nuclear Membrane Disassembly Striated Muscle Cell Development Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Membrane Disassembly Nuclear Membrane Disassembly MAP Kinase Activity Muscle Cell Development Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Toxic Substance Regulation Of Sister Chromatid Segregation Regulation Of Attachment Of Spindle Microtubules To Kinetochore Outer Kinetochore Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Localization To Chromosome Peptidyl-threonine Phosphorylation Microtubule Polymerization Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Regulation Of Circadian Rhythm Fc-epsilon Receptor Signaling Pathway Lymphocyte Proliferation Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Nuclear Division Regulation Of Cell Cycle G2/M Phase Transition Mononuclear Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Endoplasmic Reticulum Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Involved In Mitosis Positive Regulation Of Chromosome Segregation Regulation Of Chromosome Segregation Cellular Response To Hypoxia Response To Iron Ion Positive Regulation Of Cell Cycle G2/M Phase Transition Response To Light Stimulus	Intracellular Signal Transduction Intracellular Signaling Cassette Regulation Of Intracellular Signal Transduction Signal Transduction MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Response To Stress Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Cellular Response To Stress Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Cellular Developmental Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Population Proliferation Response To Growth Factor Regulation Of Signaling Cellular Response To Oxygen-containing Compound Regulation Of Cell Communication Regulation Of DNA-templated Transcription Positive Regulation Of Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of MAPK Cascade Regulation Of Transcription By RNA Polymerase II Response To Lipid Positive Regulation Of Cell Communication Positive Regulation Of Signaling Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Multicellular Organismal Process Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Response To Hormone Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Cell Surface Receptor Signaling Pathway Programmed Cell Death Cell Death Regulation Of Cell Differentiation
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