PKMYT1 and STEAP3

Number of citations of the paper that reports this interaction (PMID 12606722)
13

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		PKMYT1	STEAP3
Gene Name		protein kinase, membrane associated tyrosine/threonine 1	STEAP family member 3, metalloreductase
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Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane	Multivesicular Body Plasma Membrane Endosome Membrane Integral Component Of Membrane
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Metal Ion Binding	Ferric-chelate Reductase Activity Protein Binding Cupric Reductase Activity Metal Ion Binding Ferric-chelate Reductase (NADPH) Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Phosphorylation Mitotic Nuclear Division Regulation Of Mitotic Nuclear Division Negative Regulation Of Phosphatase Activity Regulation Of Cell Cycle	Cellular Iron Ion Homeostasis Apoptotic Process Cell Cycle Protein Secretion Copper Ion Import Transferrin Transport Transmembrane Transport Oxidation-reduction Process Ferric Iron Import Into Cell Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Exosomal Secretion
Pathways		Cyclin A/B1 associated events during G2/M transition G2/M Checkpoints G1/S Transition Cell Cycle Checkpoints G2/M Transition Cyclin E associated events during G1/S transition Mitotic G1-G1/S phases Mitotic G2-G2/M phases Cell Cycle, Mitotic Polo-like kinase mediated events G2/M DNA replication checkpoint	Iron uptake and transport Transferrin endocytosis and recycling
Drugs
Diseases
GWAS		Metabolic syndrome ( 20694148)
Protein-Protein Interactions		8 interactors: BCL2 CCNB1 CDK1 MAPK10 MAPK8 PIN1 PLK1 STEAP3	5 interactors: BAD BNIP3L PKMYT1 SETD7 TPT1
Entrez ID		9088	55240
HPRD ID		03920	10285
Ensembl ID		ENSG00000127564	ENSG00000115107
Uniprot IDs		B4DZM6 Q0IJ49 Q99640	B8ZZX6 Q658P3
PDB IDs		3P1A	2VNS 2VQ3
Enriched GO Terms of Interacting Partners?		Peptidyl-serine Phosphorylation Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Catalytic Activity Positive Regulation Of Phosphorylation Positive Regulation Of Protein Ubiquitination Regulation Of Mitotic Cell Cycle Positive Regulation Of Protein Modification Process Peptidyl-amino Acid Modification Mitotic Nuclear Envelope Disassembly Response To Toxic Substance Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Phosphorylation Nuclear Envelope Disassembly Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Ubiquitination Peptidyl-threonine Phosphorylation Positive Regulation Of Transferase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of Phosphorylation Protein Phosphorylation Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Toll-like Receptor 2 Signaling Pathway JUN Phosphorylation Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Muscle Tissue Development MyD88-independent Toll-like Receptor Signaling Pathway Nuclear Envelope Organization Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Phosphorus Metabolic Process Cellular Response To Stress Toll-like Receptor 4 Signaling Pathway Innate Immune Response Response To Metal Ion Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway	Response To Virus Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Mitochondrial Membrane Organization Apoptotic Mitochondrial Changes Cellular Response To Chromate Response To Other Organism Response To Biotic Stimulus Positive Regulation Of Mitochondrial Membrane Potential Suppression By Virus Of Host Apoptotic Process Mitochondrial Transport Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Mitochondrial Protein Catabolic Process Negative Regulation Of Cell Death Positive Regulation Of Apoptotic Process By Virus Glucose Catabolic Process Positive Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Glucokinase Activity Peptidyl-lysine Monomethylation Response To Chromate Organelle Organization Positive Regulation Of Killing Of Cells Of Other Organism Regulation Of Killing Of Cells Of Other Organism Cellular Process Regulating Host Cell Cycle In Response To Virus Cellular Response To Nicotine Apoptotic Signaling Pathway Mitochondrial Outer Membrane Permeabilization Regulation Of Apoptotic Process Response To Oleic Acid Pore Complex Assembly Modulation By Virus Of Host Process Peptidyl-lysine Dimethylation Type B Pancreatic Cell Proliferation Regulation Of Cell Death ADP Metabolic Process Mitochondrion Organization Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Cellular Response To Virus Positive Regulation Of B Cell Differentiation Heterochromatin Organization Response To External Stimulus Positive Regulation Of Mitochondrial Membrane Permeability Modulation By Virus Of Host Morphology Or Physiology Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Killing Of Cells Of Other Organism
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