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PKMYT1 and MAPK10
Number of citations of the paper that reports this interaction (PMID
19204086
)
6
Data Source:
BioGRID
(pull down, enzymatic study)
PKMYT1
MAPK10
Gene Name
protein kinase, membrane associated tyrosine/threonine 1
mitogen-activated protein kinase 10
Image
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Nucleoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Cytosol
Membrane
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Metal Ion Binding
JUN Kinase Activity
MAP Kinase Kinase Activity
Protein Binding
ATP Binding
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Protein Phosphorylation
Mitotic Nuclear Division
Regulation Of Mitotic Nuclear Division
Negative Regulation Of Phosphatase Activity
Regulation Of Cell Cycle
Activation Of MAPK Activity
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Protein Phosphorylation
Signal Transduction
JNK Cascade
JUN Phosphorylation
Response To Light Stimulus
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Regulation Of Circadian Rhythm
Innate Immune Response
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Stress-activated MAPK Cascade
Pathways
Cyclin A/B1 associated events during G2/M transition
G2/M Checkpoints
G1/S Transition
Cell Cycle Checkpoints
G2/M Transition
Cyclin E associated events during G1/S transition
Mitotic G1-G1/S phases
Mitotic G2-G2/M phases
Cell Cycle, Mitotic
Polo-like kinase mediated events
G2/M DNA replication checkpoint
Toll Like Receptor 7/8 (TLR7/8) Cascade
Cellular Senescence
FCERI mediated MAPK activation
Toll Like Receptor TLR6:TLR2 Cascade
Activated TLR4 signalling
Toll Like Receptor TLR1:TLR2 Cascade
Activation of the AP-1 family of transcription factors
MyD88 cascade initiated on plasma membrane
Toll Like Receptor 5 (TLR5) Cascade
MyD88 dependent cascade initiated on endosome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88:Mal cascade initiated on plasma membrane
Toll Like Receptor 9 (TLR9) Cascade
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Innate Immune System
TRIF-mediated TLR3/TLR4 signaling
MAP kinase activation in TLR cascade
MyD88-independent cascade
Toll Like Receptor 2 (TLR2) Cascade
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
Oxidative Stress Induced Senescence
Toll Like Receptor 3 (TLR3) Cascade
Toll Like Receptor 4 (TLR4) Cascade
Fc epsilon receptor (FCERI) signaling
MAPK targets/ Nuclear events mediated by MAP kinases
Drugs
2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One
Cyclohexyl-{4-[5-(3,4-Dichlorophenyl)-2-Piperidin-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine
Cyclopropyl-{4-[5-(3,4-Dichlorophenyl)-2-[(1-Methyl)-Piperidin]-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine
9-(4-Hydroxyphenyl)-2,7-Phenanthroline
Phosphoaminophosphonic Acid-Adenylate Ester
N-(tert-butyl)-4-[5-(pyridin-2-ylamino)quinolin-3-yl]benzenesulfonamide
N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE
N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide
4-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-N-ethylpiperidine-1-carboxamide
(3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-[(E)-2-phenylethenyl]-1H-indole-2,3-dione 3-oxime
(3E)-5-fluoro-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-1H-indole-2,3-dione 3-oxime
(3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-phenyl-1H-indole-2,3-dione 3-oxime
5-bromo-N-(3-chloro-2-(4-(prop-2-ynyl)piperazin-1-yl)phenyl)furan-2-carboxamide
N-cyclohexyl-4-imidazo[1,2-a]pyridin-3-yl-N-methylpyrimidin-2-amine
N-{2\'-[(4-FLUOROPHENYL)AMINO]-4,4\'-BIPYRIDIN-2-YL}-4-METHOXYCYCLOHEXANECARBOXAMIDE
2-{4-[(4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]piperidin-1-yl}-N-methylacetamide
1-(3-BROMOPHENYL)-7-CHLORO-6-METHOXY-3,4-DIHYDROISOQUINOLINE
Diseases
GWAS
Metabolic syndrome (
20694148
)
Liver enzyme levels (alanine transaminase) (
22001757
)
Protein-Protein Interactions
8 interactors:
BCL2
CCNB1
CDK1
MAPK10
MAPK8
PIN1
PLK1
STEAP3
34 interactors:
APP
ARRB1
ARRB2
ATF2
BCL2L11
CDK5
CDKN1B
CDKN2A
CDKN2C
CEP290
CREBBP
DUSP10
DUSP16
ELK1
GTF3C1
HAX1
HDAC9
HNRNPK
JUN
KIF26A
LDHA
MAP2K4
MAPK8IP2
MAPK8IP3
MAPKBP1
MCL1
PKMYT1
PLIN2
RELA
SH3BP5
STMN2
TNIP1
TP53
UNC119
Entrez ID
9088
5602
HPRD ID
03920
04207
Ensembl ID
ENSG00000127564
ENSG00000109339
Uniprot IDs
B4DZM6
Q0IJ49
Q99640
A8MWW6
P53779
Q499Y8
PDB IDs
3P1A
1JNK
1PMN
1PMQ
1PMU
1PMV
2B1P
2EXC
2O0U
2O2U
2OK1
2P33
2R9S
2WAJ
2ZDT
2ZDU
3CGF
3CGO
3DA6
3FI2
3FI3
3FV8
3G90
3G9L
3G9N
3KVX
3OXI
3OY1
3PTG
3RTP
3TTI
3TTJ
3V6R
3V6S
4H36
4H39
4H3B
Enriched GO Terms of Interacting Partners
?
Peptidyl-serine Phosphorylation
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Catalytic Activity
Positive Regulation Of Phosphorylation
Positive Regulation Of Protein Ubiquitination
Regulation Of Mitotic Cell Cycle
Positive Regulation Of Protein Modification Process
Peptidyl-amino Acid Modification
Mitotic Nuclear Envelope Disassembly
Response To Toxic Substance
Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Phosphorylation
Nuclear Envelope Disassembly
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Ubiquitination
Peptidyl-threonine Phosphorylation
Positive Regulation Of Transferase Activity
Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Regulation Of Phosphorylation
Protein Phosphorylation
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Regulation Of Catalytic Activity
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Toll-like Receptor 2 Signaling Pathway
JUN Phosphorylation
Toll-like Receptor 9 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Striated Muscle Tissue Development
Positive Regulation Of Muscle Tissue Development
MyD88-independent Toll-like Receptor Signaling Pathway
Nuclear Envelope Organization
Toll-like Receptor 3 Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Phosphorus Metabolic Process
Cellular Response To Stress
Toll-like Receptor 4 Signaling Pathway
Innate Immune Response
Response To Metal Ion
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Phosphorus Metabolic Process
Regulation Of Protein Phosphorylation
Regulation Of Phosphorylation
Regulation Of Protein Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Kinase Activity
Positive Regulation Of Neuron Death
Regulation Of Kinase Activity
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Metabolic Process
Response To Stress
Positive Regulation Of Neuron Apoptotic Process
Regulation Of Catalytic Activity
Regulation Of Intracellular Signal Transduction
Stress-activated MAPK Cascade
Regulation Of Signal Transduction
Stress-activated Protein Kinase Signaling Cascade
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Apoptotic Mitochondrial Changes
Cell Communication
MyD88-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of Cellular Biosynthetic Process
Response To Abiotic Stimulus
Negative Regulation Of Protein Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Innate Immune Response
Cellular Response To Stimulus
Regulation Of Signaling
Apoptotic Process
Regulation Of Metabolic Process
Response To Stimulus
Negative Regulation Of Catalytic Activity
Cellular Response To Stress
Programmed Cell Death
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Cell Death
Death
Positive Regulation Of Transcription, DNA-templated
Toll-like Receptor Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Developmental Process
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Tagcloud
?
acclimatized
adra1d
altitude
araf
argef11
arhgap24
ascent
cardiogenic
circuitry
cldn23
cldn6
ece1
ednra
genic
hape
inciting
map2k2
map2k7
mylk
oxphos
pak3
pathoetiology
plcb1
pxn
skew
sos1
unacclimatized
vasoconstriction
vcam1
Tagcloud (Difference)
?
acclimatized
adra1d
altitude
araf
argef11
arhgap24
ascent
cardiogenic
circuitry
cldn23
cldn6
ece1
ednra
genic
hape
inciting
map2k2
map2k7
mylk
oxphos
pak3
pathoetiology
plcb1
pxn
skew
sos1
unacclimatized
vasoconstriction
vcam1
Tagcloud (Intersection)
?