MDM4 and MAGEA1

Number of citations of the paper that reports this interaction (PubMedID 25590999)
60

Data Source:
BioGRID (two hybrid)

		MDM4	MAGEA1
Description		MDM4 regulator of p53	MAGE family member A1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Repressor Complex	Nucleus Cytoplasm Plasma Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Enzyme Binding Metal Ion Binding	Protein Binding Histone Deacetylase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Heart Valve Development Atrioventricular Valve Morphogenesis Endocardial Cushion Morphogenesis Ventricular Septum Development Atrial Septum Development Negative Regulation Of Cell Population Proliferation Protein Ubiquitination DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cell Population Proliferation Negative Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process Protein-containing Complex Organization Negative Regulation Of DNA-templated Transcription Protein Stabilization Regulation Of Cell Cycle Protein-containing Complex Assembly Regulation Of Biological Quality Cellular Response To Hypoxia	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Notch Signaling Pathway
Pathways		Oxidative Stress Induced Senescence Oncogene Induced Senescence Ub-specific processing proteases Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation Stabilization of p53
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Breast cancer ( 23535733 27117709) Breast cancer (estrogen-receptor negative) ( 29058716 27117709) Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative) ( 24325915) Breast Cancer in BRCA1 mutation carriers ( 23544013) Cognitive performance ( 19734545) Diastolic blood pressure ( 27618452 30578418) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Fish- and plant-related diet ( 32066663) Glioma ( 28346443) Haemorrhoidal disease ( 33888516) Levodopa wearing off effect (time symptoms uncontrolled) in Parkinson's disease (response to zonisamide) ( 32355309) Non-glioblastoma glioma ( 28346443) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Prostate cancer ( 23535732) Regular attendance at a religious group ( 29970889) Systolic blood pressure ( 27618452) Type 2 diabetes ( 32499647)
Interacting Genes		66 interacting genes: AIRIM AKT1 APP ARF1 ATM BECN1 CAPN7 CASP3 CBLC CD160 CD44 CDK1 CDK4 CDKN2A CDKN2B CHEK1 CHEK2 CSNK1A1 E2F1 EP300 EPHA2 FGFR4 GLIS2 HGF LATS2 LRSAM1 MAGEA1 MAP2K5 MDM2 MKRN3 MNAT1 NAA10 NF2 NRON PELI1 PRKAA1 RAD54B RB1 RNF115 S100B SFN SMAD3 SMAD4 SMARCA2 TOP2A TP53 TP63 TP73 TRIM46 TRIM55 UBC UBE2D1 UBE2D2 UBE2D3 UBE3A USP7 VPS26C WDR5 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZKSCAN3 ZKSCAN4	25 interacting genes: ABI2 CEP57L1 DNM1L HDAC1 HLA-A HLA-B HYPK LRSAM1 MDM4 MIEF1 NOTCH1 PBX3 PCGF6 RAB17 RNF166 S100A9 SELPLG SFN SGK1 SH3GLB2 SHFL SNW1 TRIM31 UQCRB ZNF564
Entrez ID		4194	4100
HPRD ID		04082	02059
Ensembl ID		ENSG00000198625	ENSG00000198681
Uniprot IDs		A0A087WTR9 A0A087WUE3 A0A087WZ58 O15151 Q59FS6 Q68DC0	P43355
PDB IDs		2CR8 2MWY 2N06 2N0U 2N0W 2N14 2VJE 2VJF 2VYR 3DAB 3EQY 3FDO 3FE7 3FEA 3JZO 3JZP 3JZQ 3LBJ 3MQR 3U15 4RXZ 5MNJ 5UML 5VK1 6Q9Q 6Q9S 6Q9U 6Q9W 6Q9Y 6YR5 6YR7 7C3Q 7C3Y 7C44 7EL4 7KJN 7MLA 8HDG 8IA5	1W72 3BO8
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Negative Regulation Of Signaling Protein Polyubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Regulation Of Cell Cycle Negative Regulation Of TORC1 Signaling Protein Ubiquitination Regulation Of Apoptotic Process Regulation Of TORC1 Signaling Protein Modification Process Post-translational Protein Modification Nucleus Regulation Of Protein Localization To Nucleus Protein Modification By Small Protein Conjugation Cellular Response To Stress Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of TOR Signaling Signal Transduction TORC1 Signaling Negative Regulation Of Macromolecule Biosynthetic Process Protein-containing Complex Regulation Of Mitotic Cell Cycle Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of TOR Signaling Regulation Of Protein Localization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Response To Nutrient Levels Regulation Of Cell Population Proliferation Negative Regulation Of Macromolecule Metabolic Process TOR Signaling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cellular Component Organization Apoptotic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA Damage Response Regulation Of Cell Cycle Phase Transition Regulation Of Protein Stability Positive Regulation Of Intracellular Signal Transduction Macromolecule Metabolic Process Macromolecule Catabolic Process Programmed Cell Death Cell Death	TAP Binding Compartment Pattern Specification Protection From Natural Killer Cell Mediated Cytotoxicity MHC Class I Protein Complex Detection Of Bacterium Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Mitochondrial Fission Regulation Of Cellular Component Organization Response To External Biotic Stimulus Epidermal Cell Differentiation Negative Regulation Of Innate Immune Response Negative Regulation Of Myotube Differentiation Innate Immune Response Recycling Endosome Membrane Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Atrioventricular Valve Morphogenesis Endocardial Cushion Morphogenesis Positive Regulation Of Mitochondrial Fission Defense Response Host-mediated Perturbation Of Symbiont Process Notch Binding Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Defense Response To Symbiont Modulation Of Process Of Another Organism Defense Response To Other Organism Response To Other Organism Positive Regulation Of Epidermal Cell Differentiation Host-mediated Perturbation Of Viral Transcription Antigen Processing And Presentation Of Endogenous Antigen Regulation Of Mitochondrial Fission Lumenal Side Of Endoplasmic Reticulum Membrane Autophagy Detection Of Biotic Stimulus Positive Regulation Of Epidermis Development Endoderm Development Regulation Of Viral Process Positive Regulation Of Glial Cell Differentiation Positive Regulation Of T Cell Mediated Cytotoxicity Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Venous Endothelial Cell Differentiation Coronary Sinus Valve Morphogenesis Foregut Morphogenesis Posterior Compartment Specification Anterior Compartment Pattern Formation S100A9 Complex Viral Process
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