MDM4 and VPS26C

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MDM4	VPS26C
Description		MDM4 regulator of p53	VPS26 endosomal protein sorting factor C
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Repressor Complex	Nucleus Endosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Enzyme Binding Metal Ion Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Heart Valve Development Atrioventricular Valve Morphogenesis Endocardial Cushion Morphogenesis Ventricular Septum Development Atrial Septum Development Negative Regulation Of Cell Population Proliferation Protein Ubiquitination DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cell Population Proliferation Negative Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process Protein-containing Complex Organization Negative Regulation Of DNA-templated Transcription Protein Stabilization Regulation Of Cell Cycle Protein-containing Complex Assembly Regulation Of Biological Quality Cellular Response To Hypoxia	Intracellular Protein Transport Endocytic Recycling
Pathways		Oxidative Stress Induced Senescence Oncogene Induced Senescence Ub-specific processing proteases Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation Stabilization of p53
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Breast cancer ( 23535733 27117709) Breast cancer (estrogen-receptor negative) ( 29058716 27117709) Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative) ( 24325915) Breast Cancer in BRCA1 mutation carriers ( 23544013) Cognitive performance ( 19734545) Diastolic blood pressure ( 27618452 30578418) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Fish- and plant-related diet ( 32066663) Glioma ( 28346443) Haemorrhoidal disease ( 33888516) Levodopa wearing off effect (time symptoms uncontrolled) in Parkinson's disease (response to zonisamide) ( 32355309) Non-glioblastoma glioma ( 28346443) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Prostate cancer ( 23535732) Regular attendance at a religious group ( 29970889) Systolic blood pressure ( 27618452) Type 2 diabetes ( 32499647)
Interacting Genes		66 interacting genes: AIRIM AKT1 APP ARF1 ATM BECN1 CAPN7 CASP3 CBLC CD160 CD44 CDK1 CDK4 CDKN2A CDKN2B CHEK1 CHEK2 CSNK1A1 E2F1 EP300 EPHA2 FGFR4 GLIS2 HGF LATS2 LRSAM1 MAGEA1 MAP2K5 MDM2 MKRN3 MNAT1 NAA10 NF2 NRON PELI1 PRKAA1 RAD54B RB1 RNF115 S100B SFN SMAD3 SMAD4 SMARCA2 TOP2A TP53 TP63 TP73 TRIM46 TRIM55 UBC UBE2D1 UBE2D2 UBE2D3 UBE3A USP7 VPS26C WDR5 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZKSCAN3 ZKSCAN4	44 interacting genes: AGTPBP1 ARHGAP21 ASH1L CBLB CCDC85A CIPC DCLK1 DDIT4L DECR2 DNAJB2 EPHB6 INCA1 KIF1A KIF21A LRIF1 MAML3 MAPK6 MAPK8IP1 MDM4 MEI4 MEOX2 MRPS35 MYRIP NRCAM NSMF PALS2 PCM1 PEG10 PMS2 PRKD2 PTPN21 RAB39B RAP1GAP RAP1GAP2 SETMAR TAF1C TEPSIN TET2 TRAPPC1 U2AF1 VPS26A VPS35L XPA ZNF655
Entrez ID		4194	10311
HPRD ID		04082	10390
Ensembl ID		ENSG00000198625	ENSG00000157538
Uniprot IDs		A0A087WTR9 A0A087WUE3 A0A087WZ58 O15151 Q59FS6 Q68DC0	A8MTY9 A8MY26 O14972
PDB IDs		2CR8 2MWY 2N06 2N0U 2N0W 2N14 2VJE 2VJF 2VYR 3DAB 3EQY 3FDO 3FE7 3FEA 3JZO 3JZP 3JZQ 3LBJ 3MQR 3U15 4RXZ 5MNJ 5UML 5VK1 6Q9Q 6Q9S 6Q9U 6Q9W 6Q9Y 6YR5 6YR7 7C3Q 7C3Y 7C44 7EL4 7KJN 7MLA 8HDG 8IA5	8P0X 8SYN 8SYO 9AU7
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Negative Regulation Of Signaling Protein Polyubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Regulation Of Cell Cycle Negative Regulation Of TORC1 Signaling Protein Ubiquitination Regulation Of Apoptotic Process Regulation Of TORC1 Signaling Protein Modification Process Post-translational Protein Modification Nucleus Regulation Of Protein Localization To Nucleus Protein Modification By Small Protein Conjugation Cellular Response To Stress Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of TOR Signaling Signal Transduction TORC1 Signaling Negative Regulation Of Macromolecule Biosynthetic Process Protein-containing Complex Regulation Of Mitotic Cell Cycle Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of TOR Signaling Regulation Of Protein Localization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Response To Nutrient Levels Regulation Of Cell Population Proliferation Negative Regulation Of Macromolecule Metabolic Process TOR Signaling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cellular Component Organization Apoptotic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA Damage Response Regulation Of Cell Cycle Phase Transition Regulation Of Protein Stability Positive Regulation Of Intracellular Signal Transduction Macromolecule Metabolic Process Macromolecule Catabolic Process Programmed Cell Death Cell Death
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