PSTPIP1 and PTPN12

Number of citations of the paper that reports this interaction (PMID 11971877)
51

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro, two hybrid)

		PSTPIP1	PTPN12
Gene Name		proline-serine-threonine phosphatase interacting protein 1	protein tyrosine phosphatase, non-receptor type 12
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Uropod Actomyosin Contractile Ring Cytosol Membrane Lamellipodium Cleavage Furrow Perinuclear Region Of Cytoplasm	Podosome Cytoplasm Cytosol Plasma Membrane Cell Junction Cell Projection
	Molecular Function	Actin Binding Protein Binding Protein Phosphatase Binding	Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding SH3 Domain Binding
	Biological Process	Endocytosis Inflammatory Response Cell Adhesion Signal Transduction Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Innate Immune Response	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation
Pathways		The NLRP3 inflammasome Inflammasomes Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		29 interactors: ABL1 BUB3 CD2 CD2AP DNM2 FAM90A1 FASLG FBXL18 KHDRBS1 LSM4 MEFV MVP PCDHB14 PRPF31 PTPN12 PTPN18 RTP5 SDCBP SH2D4A SHBG SPG7 TRAF3IP3 TULP3 UBE2W WAS WASF1 WASF2 WASL ZNF175	37 interactors: ABL1 APP BAG6 BCAR1 CGA CSH1 CSH2 CSK EFS EGFR FLT3 GRB2 IFT20 INSR JAK2 LPXN MYCBP2 NEDD9 PRKACA PRKCA PSG9 PSTPIP1 PSTPIP2 PTK2 PTK2B PXN RBM19 SHC1 SMAD5 SORBS2 STX16 TEX10 TGFB1I1 THAP2 UTRN WAS ZFP2
Entrez ID		9051	5782
HPRD ID		05891	02513
Ensembl ID		ENSG00000140368	ENSG00000127947
Uniprot IDs		O43586	A4D1C5 B4E105 E9PBR5 Q05209
PDB IDs		2DIL
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Actin Nucleation Negative Regulation Of Membrane Tubulation Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Nucleation Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Positive Regulation Of Interferon-gamma Secretion Regulation Of Cytoskeleton Organization Movement Of Cell Or Subcellular Component Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Actin Cytoskeleton Organization Actin Filament-based Movement Actin Filament-based Process Mitotic Cell Cycle Process Substrate-dependent Cell Migration, Cell Extension Cellular Component Assembly Regulation Of Oxidoreductase Activity Regulation Of Cellular Component Organization Mitotic Cell Cycle Signaling Actin Polymerization Or Depolymerization Cytoskeleton Organization Cell Communication Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune System Process Signal Transduction Rac Protein Signal Transduction Cell Projection Assembly Actin Filament Organization Mitotic Nuclear Division Nitric Oxide Metabolic Process Regulation Of Catalytic Activity Reactive Nitrogen Species Metabolic Process Endocytosis Cell Cycle Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Endothelial Cell Apoptotic Process Cellular Response To Stimulus Cell Surface Receptor Signaling Pathway Substrate-dependent Cell Migration Organelle Organization Positive Regulation Of Organelle Organization Regulation Of Nitric-oxide Synthase Activity	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Adhesion Protein Autophosphorylation Cellular Response To Organonitrogen Compound Peptidyl-tyrosine Phosphorylation Movement Of Cell Or Subcellular Component Response To Organonitrogen Compound Cell Activation Regulation Of Protein Kinase Activity Blood Coagulation Peptidyl-tyrosine Autophosphorylation Hemostasis Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Peptide Hormone Stimulus Cellular Response To Hormone Stimulus Positive Regulation Of MAPK Cascade Cellular Response To Peptide Signal Transduction Regulation Of Kinase Activity Regulation Of MAPK Cascade Innate Immune Response Cell Surface Receptor Signaling Pathway Signaling Positive Regulation Of Protein Phosphorylation Cell Communication Regulation Of MAP Kinase Activity Peptidyl-amino Acid Modification Response To Hormone Cellular Response To Growth Factor Stimulus Platelet Activation Regulation Of Body Fluid Levels Response To Growth Factor Wound Healing Locomotion Response To Peptide Hormone Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cell Migration Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Kinase Activity Protein Phosphorylation Immune System Process Regulation Of Immune System Process Regulation Of Phosphorylation Response To Peptide
Tagcloud ?		adipocyte biologically chick chicken chickens cutoff experimentally klf5 lpin1 luciferase map3k7 mettl14 microrna mir miranda mirna pck2 pdcd5 pycr2 slc2a2 splenocytes tardbp tnfsf10 transcriptionally tumourigenesis ube2e3 ubiquitously utrs vertebrate	cytoskeleton dataset deposited dysregulation exerts expand heterodimeric http identifier inositol inpp5d mapkapk2 nad nadk nonreceptor org pertaining phosphatases phosphoproteome phosphoproteomic polyphosphate proteomecentral proteomexchange pxd000984 reorganization ripk1 silac threonine tnfrsf
Tagcloud (Difference) ?		adipocyte biologically chick chicken chickens cutoff experimentally klf5 lpin1 luciferase map3k7 mettl14 microrna mir miranda mirna pck2 pdcd5 pycr2 slc2a2 splenocytes tardbp tnfsf10 transcriptionally tumourigenesis ube2e3 ubiquitously utrs vertebrate	cytoskeleton dataset deposited dysregulation exerts expand heterodimeric http identifier inositol inpp5d mapkapk2 nad nadk nonreceptor org pertaining phosphatases phosphoproteome phosphoproteomic polyphosphate proteomecentral proteomexchange pxd000984 reorganization ripk1 silac threonine tnfrsf
Tagcloud (Intersection) ?