PTPN12 and STX16

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
HPRD (two hybrid)

		PTPN12	STX16
Gene Name		protein tyrosine phosphatase, non-receptor type 12	syntaxin 16
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Podosome Cytoplasm Cytosol Plasma Membrane Cell Junction Cell Projection	Golgi Membrane Nucleolus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Cytosol Focal Adhesion Endomembrane System Membrane Integral Component Of Membrane SNARE Complex Golgi Cisterna Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding SH3 Domain Binding	SNARE Binding SNAP Receptor Activity Protein Binding Syntaxin Binding
	Biological Process	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation	Intracellular Protein Transport Intra-Golgi Vesicle-mediated Transport Vesicle Fusion Retrograde Transport, Endosome To Golgi Vesicle Docking Golgi Ribbon Formation
Pathways
Drugs
Diseases
GWAS			Cardiovascular disease risk factors ( 20838585)
Protein-Protein Interactions		37 interactors: ABL1 APP BAG6 BCAR1 CGA CSH1 CSH2 CSK EFS EGFR FLT3 GRB2 IFT20 INSR JAK2 LPXN MYCBP2 NEDD9 PRKACA PRKCA PSG9 PSTPIP1 PSTPIP2 PTK2 PTK2B PXN RBM19 SHC1 SMAD5 SORBS2 STX16 TEX10 TGFB1I1 THAP2 UTRN WAS ZFP2	10 interactors: MEOX2 NAPB PTPN12 STX4 STX6 VAMP3 VAMP4 VAMP5 VPS45 VTI1A
Entrez ID		5782	8675
HPRD ID		02513	04718
Ensembl ID		ENSG00000127947	ENSG00000124222
Uniprot IDs		A4D1C5 B4E105 E9PBR5 Q05209	B4DJX9 O14662
PDB IDs
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Adhesion Protein Autophosphorylation Cellular Response To Organonitrogen Compound Peptidyl-tyrosine Phosphorylation Movement Of Cell Or Subcellular Component Response To Organonitrogen Compound Cell Activation Regulation Of Protein Kinase Activity Blood Coagulation Peptidyl-tyrosine Autophosphorylation Hemostasis Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Peptide Hormone Stimulus Cellular Response To Hormone Stimulus Positive Regulation Of MAPK Cascade Cellular Response To Peptide Signal Transduction Regulation Of Kinase Activity Regulation Of MAPK Cascade Innate Immune Response Cell Surface Receptor Signaling Pathway Signaling Positive Regulation Of Protein Phosphorylation Cell Communication Regulation Of MAP Kinase Activity Peptidyl-amino Acid Modification Response To Hormone Cellular Response To Growth Factor Stimulus Platelet Activation Regulation Of Body Fluid Levels Response To Growth Factor Wound Healing Locomotion Response To Peptide Hormone Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cell Migration Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Kinase Activity Protein Phosphorylation Immune System Process Regulation Of Immune System Process Regulation Of Phosphorylation Response To Peptide	Membrane Fusion Vesicle Fusion Organelle Fusion Vesicle Organization Golgi Ribbon Formation SNARE Complex Assembly Vesicle-mediated Transport Membrane Organization Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Golgi Vesicle Transport Establishment Of Localization In Cell Exocytosis Cellular Protein Localization Protein Transport Establishment Of Protein Localization Cellular Localization Intracellular Transport Endomembrane System Organization Secretion By Cell Protein Localization Retrograde Transport, Endosome To Golgi Secretion Golgi Organization Vesicle Docking Membrane Docking Neurotransmitter Secretion Regulation Of Neurotransmitter Levels Golgi To Plasma Membrane Protein Transport Neurotransmitter Transport Endosomal Transport Golgi To Plasma Membrane Transport Transport Regulation Of Establishment Of Protein Localization To Plasma Membrane Regulation Of Protein Localization To Plasma Membrane Vesicle Docking Involved In Exocytosis Cellular Protein Complex Assembly Establishment Of Protein Localization To Plasma Membrane Organelle Organization Positive Regulation Of Eosinophil Degranulation Skeletal Muscle Tissue Development Voluntary Musculoskeletal Movement Skeletal Muscle Organ Development Protein Localization To Plasma Membrane Cellular Macromolecular Complex Assembly SNARE Complex Disassembly Somite Specification Cytoplasmic Transport Positive Regulation Of Protein Localization To Cell Surface Golgi To Vacuole Transport
Tagcloud ?		cytoskeleton dataset deposited dysregulation exerts expand heterodimeric http identifier inositol inpp5d mapkapk2 nad nadk nonreceptor org pertaining phosphatases phosphoproteome phosphoproteomic polyphosphate proteomecentral proteomexchange pxd000984 reorganization ripk1 silac threonine tnfrsf	attachment cog cog4 cog8 defining ethylmalemide golgi gs27 initiate intermediates machinery namely oligomeric platforms redirection relocalization retrograde reveals snap29 snares sorting stx5 stx6 tethering tethers uncover vesicles vesicular vicinity
Tagcloud (Difference) ?		cytoskeleton dataset deposited dysregulation exerts expand heterodimeric http identifier inositol inpp5d mapkapk2 nad nadk nonreceptor org pertaining phosphatases phosphoproteome phosphoproteomic polyphosphate proteomecentral proteomexchange pxd000984 reorganization ripk1 silac threonine tnfrsf	attachment cog cog4 cog8 defining ethylmalemide golgi gs27 initiate intermediates machinery namely oligomeric platforms redirection relocalization retrograde reveals snap29 snares sorting stx5 stx6 tethering tethers uncover vesicles vesicular vicinity
Tagcloud (Intersection) ?