PSTPIP1 and PTPN18

Number of citations of the paper that reports this interaction (PubMedID 9265651)
84

Data Source:
HPRD (in vivo)

		PSTPIP1	PTPN18
Description		proline-serine-threonine phosphatase interacting protein 1	protein tyrosine phosphatase non-receptor type 18
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GO Annotations	Cellular Component	Uropod Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Lamellipodium Cleavage Furrow Cell Projection Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Identical Protein Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity
	Biological Process	Immune System Process Endocytosis Inflammatory Response Cell Adhesion Signal Transduction Innate Immune Response	Blastocyst Formation Protein Dephosphorylation Negative Regulation Of ERBB Signaling Pathway
Pathways		The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection	Downregulation of ERBB2 signaling Interleukin-37 signaling
Drugs
Diseases		Pyogenic sterile arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome
GWAS		Hip circumference adjusted for BMI ( 34021172) Neurofibrillary tangles ( 31497858) Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		64 interacting genes: ABL1 AXIN1 BUB3 CCDC172 CD2 CD2AP CHD4 CWF19L2 DHX40 DNM2 EHHADH EXOC5 FAM90A1 FASLG FBXL18 HAPLN2 HHEX HMG20A HSF2BP IL16 KANK2 KHDRBS1 LIN37 LSM4 MCRS1 MEFV MOS MVP NAV2 NCBP1 PCDHB14 PNKP PRPF31 PRR35 PTPN12 PTPN18 RINT1 RNPS1 RPL9 RTP5 RXRB SCNM1 SDCBP SH2D4A SHBG SMARCD1 SPG7 SYCE1 TFIP11 TPH1 TRAF3IP3 TSGA10IP TTC1 TULP3 UBE2W WAS WASF1 WASF2 WASL ZC2HC1C ZNF175 ZNF408 ZNF580 ZNF688	13 interacting genes: AATK ABL1 ARHGAP5 CNKSR1 CSK EGFR ERBB2 GAB1 PSTPIP1 PSTPIP2 SNCA SRC TEC
Entrez ID		9051	26469
HPRD ID		05891	05961
Ensembl ID		ENSG00000140368	ENSG00000072135
Uniprot IDs		A0A0S2Z5P3 J3KPG6 O43586	Q99952
PDB IDs		2DIL 7AAL 7AAM 7AAN	2OC3 4GFU 4GFV 4NND
Enriched GO Terms of Interacting Partners?		Actin Filament Polymerization Protein Polymerization MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Actin Polymerization Or Depolymerization SH3 Domain Binding Negative Regulation Of Membrane Tubulation Protein Binding Regulation Of Plasma Membrane Organization MRNA Processing RNA Splicing MRNA Metabolic Process Regulation Of ERBB Signaling Pathway Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Spliceosomal Tri-snRNP Complex Regulation Of Double-strand Break Repair Regulation Of DNA Repair Negative Regulation Of ERBB Signaling Pathway Lamellipodium Morphogenesis Negative Regulation Of Cellular Component Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Actin Filament Organization Podosome Regulation Of Vitamin D Receptor Signaling Pathway Substrate-dependent Cell Migration, Cell Extension Spliceosomal Complex Actin Cytoskeleton Ruffle SCAR Complex	Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase Activity ERBB Signaling Pathway Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Perinuclear Region Of Cytoplasm Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ERBB2 Signaling Pathway Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade ATP Binding Response To Growth Factor Cytoplasm SH2 Domain Binding Protein Phosphorylation Regulation Of Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Phosphorylation Transferase Activity Nucleotide Binding Cell-cell Junction ERBB2-EGFR Signaling Pathway Protein Domain Specific Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Signal Transduction Cytosol Cell Surface Receptor Signaling Pathway Cytoskeleton Plasma Membrane Integrin-mediated Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Response To Epinephrine Immune Response-regulating Cell Surface Receptor Signaling Pathway Ruffle Membrane Protein Tyrosine Kinase Activator Activity Positive Regulation Of Locomotion Neuron Apoptotic Process Negative Regulation Of Cell Adhesion T Cell Receptor Signaling Pathway Glial Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Endocytosis Proline-rich Region Binding Positive Regulation Of Phosphate Metabolic Process Regulation Of Locomotion Regulation Of Multicellular Organismal Process Regulation Of MAPK Cascade
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