PTPN12 and ZNF510

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		PTPN12	ZNF510
Description		protein tyrosine phosphatase non-receptor type 12	zinc finger protein 510
Image			No pdb structure
GO Annotations	Cellular Component	Podosome Nucleus Nucleoplasm Cytoplasm Cytosol Focal Adhesion Cell Projection Anchoring Junction	Nucleus
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity SH3 Domain Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Tissue Regeneration Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of ERBB Signaling Pathway Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process
Pathways		SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling EGFR downregulation Signaling by PDGF Downregulation of ERBB2 signaling Interleukin-37 signaling Constitutive Signaling by Overexpressed ERBB2	Generic Transcription Pathway
Drugs		Tiludronic acid
Diseases
GWAS		A body shape index ( 34021172) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31015462) Lymphocyte count ( 32888494) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		57 interacting genes: AATK ABL1 ANP32B APP BAG6 BCAR1 CCDC180 CGA CSH1 CSH2 CSK EFS EGFR ERBB3 ERBB4 FANCC FGFR2 FGFR4 FLT3 FRAT2 GRB2 IFT20 IGF1R INSR JAK2 KDR LMTK2 LPXN MYCBP2 NEDD9 PPP3R2 PRKACA PRKCA PSG9 PSTPIP1 PSTPIP2 PTK2 PTK2B PTK7 PXN RBM19 ROR2 SFRP4 SHC1 SMAD1 SMAD5 SORBS2 STX16 STX17 TENM1 TEX10 TGFB1I1 THAP2 UTRN WAS ZFP2 ZNF510	21 interacting genes: APC AURKA BRAF BUB1 CCND1 CDH1 CTNNA1 DLC1 EGFR FBXW7 MLH3 MSH2 ODC1 PDGFRL PTPN12 PTPRJ SMAD1 SMAD2 SMAD4 STK11 TGFBR2
Entrez ID		5782	22869
HPRD ID		02513	18348
Ensembl ID		ENSG00000127947	ENSG00000081386
Uniprot IDs		B4E105 Q05209	Q6NUI8 Q9Y2H8
PDB IDs		5HDE 5J8R 5O2P
Enriched GO Terms of Interacting Partners?		Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Protein Kinase Activity Signal Transduction Kinase Activity Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Autophosphorylation Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade ERBB Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Phosphorylation Positive Regulation Of Signal Transduction Phosphorylation Receptor Complex Focal Adhesion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Population Proliferation Cellular Response To Growth Factor Stimulus ATP Binding Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Migration Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Cell Motility Positive Regulation Of Phosphate Metabolic Process Perinuclear Region Of Cytoplasm Response To Growth Factor Positive Regulation Of Locomotion Growth Hormone Receptor Signaling Pathway Animal Organ Development Regulation Of Developmental Process Positive Regulation Of Cell Population Proliferation Regulation Of Locomotion Insulin Receptor Substrate Binding Positive Regulation Of Protein Phosphorylation Anchoring Junction Positive Regulation Of Cellular Component Organization Positive Regulation Of Phosphorylation Regulation Of Cell Motility Positive Regulation Of Developmental Process	Gamma-catenin Binding Animal Organ Development Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis SMAD Protein Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell Differentiation SMAD Protein Complex Response To Growth Factor Cell Population Proliferation Heteromeric SMAD Protein Complex Developmental Process Regulation Of Protein Catabolic Process Intracellular Signal Transduction Secondary Palate Development Cell Surface Receptor Signaling Pathway Regulation Of Cell Cycle Phase Transition Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Negative Regulation Of Developmental Process Negative Regulation Of Cell Differentiation Cellular Response To Growth Factor Stimulus I-SMAD Binding Response To UV Negative Regulation Of Cell Population Proliferation Ubiquitin Protein Ligase Binding Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Homomeric SMAD Protein Complex Protein Kinase Activity Regulation Of Mitotic Cell Cycle Endocardial Cushion Morphogenesis Response To Light Stimulus Regulation Of ERBB Signaling Pathway Animal Organ Morphogenesis Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Cell Development Cell Junction Regulation Of Protein Metabolic Process Activin Responsive Factor Complex Developmental Growth Regulation Of Cell Communication Regulation Of Signaling Catenin Complex Kinase Activity Ruffle Membrane Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Anchoring Junction Beta-catenin Binding
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